Oxidative Stress in Cerebral Ischemia/Reperfusion Injury
Roberto Anaya-Fernández,
Roberto Anaya-Prado,
Michelle M. Anaya-Fernandez
et al.
Abstract:Oxidative stress in cerebral ischemia/reperfusion injury (CIRI) involves reactive oxygen and nitrogen species (ROS and RNS). Despite efficient antioxidant pathways in the brain, hypoxia triggers the production of oxygen free radicals and downregulates ATP, which leads to oxidative stress. Sources of free radicals during CIRI include Ca<sup>2+</sup>-dependent enzymes, phospholipid degradation and mitochondrial enlargement. Upon reperfusion, the abrupt increase of oxygen triggers a massive radical pr… Show more
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