Oxidative Stress in Cardiovascular Disease: A New Avenue Toward Future Therapeutic Approaches

Inagi, Reiko

doi:10.2174/157489006777442450

Cited by 33 publications

(26 citation statements)

References 96 publications

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“…Many of the secondary benefits of statins, fish oil, ARBs, and ACE (Examples 2 and 3) are hypothesized to be due to suppression of inflammation. 110,111 Numerous studies support the use of low-dose acetyl salicylic acid (ASA, aspirin) to attenuate augmented platelet function that contributes to vascular disease. 112 ASA at higher doses may be chemopreventive for colonic tumors.…”

Section: Example #4: Antiinflammationmentioning

confidence: 99%

Applied Healthspan Engineering

Larrick

Mendelsohn

2010

Rejuvenation Research

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According to the Homeric Hymn to Aphrodite, when Eos asked Zeus for Tithonus to be granted immortality, she forgot to ask for eternal youth. Applied Healthspan Engineering (AHE) seeks to address this problem. All organisms have a minimal level of functional reserve required to sustain life that eventually declines to a point incompatible with survival at death. AHE seeks to maintain or restore optimal functional reserve of critical tissues and organs. Tissue reserve correlates with well being. Diet, physical exercise, and currently available smallmolecule-based therapeutics may attenuate the rate of decline of specific organs or organ systems, but are unlikely to restore lost reserve. Inherent evolutionary-derived limitations in tissue homeostasis and cell maintenance necessitate the development of therapies to enhance regenerative processes and possibly replace whole organs or tissues. AHE supports the study of cell, tissue, and organ homeostatic mechanisms to derive new regenerative and tissue replacement therapies to extend the period of human health.

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Section: Example #4: Antiinflammationmentioning

confidence: 99%

Applied Healthspan Engineering

Larrick

Mendelsohn

2010

Rejuvenation Research

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“…However, different physiological or pathophysiological stimuli can generate abundant ROS which lead to oxidative stress characterized by an imbalance between the generation ROS and the capacity of the intrinsic antioxidant defense system. Oxidative stress can damage DNA, lipids, and proteins, and ultimately lead to tissue injury [30]. An increasing body of evidence suggests that oxidative stress induced by H 2 O 2 is involved in the pathogenesis of cardiovascular diseases, such as cardiac ischemic-reperfusion injury and hypertrophy [31,32].…”

Section: Discussionmentioning

confidence: 99%

“…As shown in Figure 3, the percentage of apoptotic cells was 5.65%˘0.35% in the control group, whereas that of the group treated with H 2 O 2 alone was 47.75%˘1.95% (p < 0.01, vs. the control group). However, the treatment with 5, 10 or 20 µmol/L isoquercitrin significantly decreased apoptotic rates to 30 To further evaluate the inhibitory effect of isoquercitrin on H2O2-induced apoptosis in EA.hy926 cells, apoptotic rates were measured by Annexin V-FITC/PI double staining using flow cytometry. As shown in Figure 3, the percentage of apoptotic cells was 5.65% ± 0.35% in the control group, whereas that of the group treated with H2O2 alone was 47.75% ± 1.95% (p < 0.01, vs. the control group).…”

Section: Isoquercitrin Inhibits H2o2-induced Apoptosis Of Eahy926 Cellsmentioning

confidence: 99%

Isoquercitrin Inhibits Hydrogen Peroxide-Induced Apoptosis of EA.hy926 Cells via the PI3K/Akt/GSK3β Signaling Pathway

Zhu

Wang

et al. 2016

Molecules

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Abstract:Oxidative stress plays a critical role in endothelial injury and the pathogenesis of diverse cardiovascular diseases, including atherosclerosis. Isoquercitrin (quercetin-3-glucoside), a flavonoid distributed widely in plants, exhibits many biological activities, including anti-allergic, anti-viral, anti-inflammatory, and anti-oxidative effects. In the present study, the inhibitory effect of isoquercitrin on H 2 O 2 -induced apoptosis of EA.hy926 cells was evaluated. MTT assays showed that isoquercitrin significantly inhibited H 2 O 2 -induced loss of viability in EA.hy926 cells. Hoechst33342/PI and Annexin V-FITC/PI fluorescent double staining indicated that isoquercitrin inhibited H 2 O 2 -induced apoptosis of EA.hy926 cells. Western blotting demonstrated that isoquercitrin prevented H 2 O 2 -induced increases in cleaved caspase-9 and cleaved caspase-3 expression, while increasing expression of anti-apoptotic protein Mcl-1. Additionally, isoquercitrin significantly increased the expression of p-Akt and p-GSK3β in a dose-dependent manner in EA.hy926 cells. LY294002, a PI3K/Akt inhibitor, inhibited isoquercitrin-induced GSK3β phosphorylation and increase of Mcl-1 expression, which indicated that regulation of isoquercitrin on Mcl-1 expression was likely related to the modulation of Akt activation. These results demonstrated that the anti-apoptotic effect of isoquercitrin on H 2 O 2 -induced EA.hy926 cells was likely associated with the regulation of isoquercitrin on Akt/GSK3β signaling pathway and that isoquercitrin could be used clinically to interfere with the progression of endothelial injury-associated cardiovascular disease.

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“…Oxidative stress is one of the main factors causing many human diseases, and antioxidants have been recognized as a useful strategy to prevent and treat the diseases (Giugliano et al, 1996;Inagi, 2006;Nunomura et al, 2006;Wood-Kaczmar et al, 2006). To find new antioxidants from natural resources has become an important approach to the development of new health care products (Slemmer et al, 2008).…”

Section: Introductionmentioning

confidence: 99%