Oxidative stress in blood plasma of patients with community-acquired pneumonia

The Level Assessment of Extracellular Nucleic Acids in the Blood of Pregnant Women with Chronic Hypertension with Superimposed Preeclampsia

“…In addition, ecNA binding to erythrocytes affects to the transport function of red cell membranes, thereby leading to a change of the osmotic resistance of red blood cells, as well as inhibiting the transport of hemoglobin and subsequent complete gas exchange, which ultimately leads to hypoxia, oxidative stress. Furthermore, ecNA binding to erythrocytes can be transformed into microvesicles, the significance and function of which remains poorly understood to date [18].…”

“…Thus, our data indicate significant changes in the level of ecNA in pregnant women with various types of hypertension and require further research; however, changes in the concentration of ecNA can be considered as one of the links in the pathogenesis of preeclampsia. In addition, it is necessary to study ecNA and simultaneously study extracellular vesicles, which may also contain ecNA (platelet's, leukocyte's, erythrocyte's vesicles, as well as endothelial vesicles) [18]. At present, the only treatment of preeclampsia, as well as severe chronic hypertension, is delivery.…”

“…Extracellular nucleic acids can exist in free form or can be absorbed on blood cells or as a part of vesicles [15], [16], [17], [18]. Usually, the amount of circulating DNA is very low in healthy people.…”