2015
DOI: 10.3390/biom5020545
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Oxidative Stress in Aging Human Skin

Abstract: Oxidative stress in skin plays a major role in the aging process. This is true for intrinsic aging and even more for extrinsic aging. Although the results are quite different in dermis and epidermis, extrinsic aging is driven to a large extent by oxidative stress caused by UV irradiation. In this review the overall effects of oxidative stress are discussed as well as the sources of ROS including the mitochondrial ETC, peroxisomal and ER localized proteins, the Fenton reaction, and such enzymes as cyclooxygenas… Show more

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Cited by 655 publications
(632 citation statements)
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References 356 publications
(401 reference statements)
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“…Antioxidant polyphenols possess tyrosinase and elastase inhibitory activity (4,36,39). In the current study, the extract from burdock leaves with antioxidant polyphenols inhibited elastase and tyrosinase activity, with their antielastase activity being stronger compared with their antityrosinase activity, which can be explained using the ROS scavenging theory of skin aging (40). These results indicate that the antiwrinkle activity of burdock leaves may be more effective than its skin-evening activity.…”
Section: Discussionmentioning
confidence: 46%
“…Antioxidant polyphenols possess tyrosinase and elastase inhibitory activity (4,36,39). In the current study, the extract from burdock leaves with antioxidant polyphenols inhibited elastase and tyrosinase activity, with their antielastase activity being stronger compared with their antityrosinase activity, which can be explained using the ROS scavenging theory of skin aging (40). These results indicate that the antiwrinkle activity of burdock leaves may be more effective than its skin-evening activity.…”
Section: Discussionmentioning
confidence: 46%
“…It is well known that skin aging is a consequence of genetically determined biological factors influenced by oxidative stress [27,28] and environmental (such as sunlight ultraviolet radiation) factors [29]. The first type of skin aging is called intrinsic aging, while the second is called extrinsic aging [30,31].…”
Section: Molecular Biologist's View Of Skin Aging: Intrinsic and Extrmentioning
confidence: 99%
“…An existing explanation for the emergence of these features is that radiation increases reactive oxygen species (ROS), which at higher concentrations may cause damage to DNA molecules, fatty acids, carbohydrates and proteins, including collagen and elastin [9,[24][25][26][27][28]. In general, aged skin exhibits an imbalance between adequate loss and replenishment of structural and functional components.…”
Section: Introductionmentioning
confidence: 99%