Oxidative Stress in Acute Serous and Purulent Pyelonephritis

Abstract

THE AIM: To study the state of the proand antioxidant system at the systemic and local level in acute serous and purulent pyelonephritis (ASP, APP). PATIENTS AND METHODS. Oxidative status was studied in 62 patients with ASP and APP, randomized by age, sex, the minimum number of co-morbidities in remission. RESULTS. It was found that the ASP, to a greater extent with the APP on the system (blood plasma, red blood cells) and local level (urine) increases the concentration of stable metabolites of nitric oxide, increases the content of lipid peroxidation products (alkyl hydroperoxides, malonic dialdehyde) and decreases the activity of the antioxidant system (superoxide dismutase levels, catalase, in plasma, urine and erythrocytes). After the comprehensive treatment of the studied indices at ASP are corrected or normalized, and at APP are subject to a minimum correction. CONCLUSION. The results reveal changes of oxidative status occurring in acute serous and purulent pyelonephritis, and also confirm the need for the comprehensive treatment of this disease using drugs with antioxidant and cytoprotective effects.