Oxidative Stress in Acute Hypobaric Hypoxia

Irarrázaval, Sebastián; Allard, Claudio; Campodónico, Juan; Pérez, Druso; Strobel, Pablo; Vásquez, Luís; Urquiaga, Inés; Echeverría, Guadalupe; Leighton, Federico

doi:10.1089/ham.2016.0119

Cited by 51 publications

(32 citation statements)

References 26 publications

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“…Our study found that exposure to high altitude resulted in upregulation in the expression of in ammatory cytokines and downregulation anti-in ammatory cytokines expression [7]. Moreover, hypobaric hypoxia induces oxidative damage and decreases antioxidative functions [20]. Considering metabolic modulation, glycolytic capacity is promoted and oxidative metabolism is suppressed in response to hypoxia [21,22].…”

Section: Discussionmentioning

confidence: 88%

DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia

Shi

Sun

et al. 2020

Preprint

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Background: Studies revealed the protective effect of DL-3-n-butylphthalide (NBP) against ischemic hypoxia diseases. However, the role of NBP in animals with hypobaric hypoxia is elusive. This study investigated the effect of NBP on animals with acute and chronic hypobaric hypoxia. Methods: SD rats and Kunming mice administrated with NBP ( 90, 180 and 360 mg/kg for mice, 60, 120, and 240 mg/kg for rats and 90, 180 and 360 mg/kg for mice 60, 120, and 240 mg/kg for rats ) were placed located in 10,000 m hypobaric hypoxia chamber. And survival analysis of animals implied that NBP could significantly improve and survival percent at 30 min were analyzed . Then, drug treated animals rats (mice) were evaluated for exhaustive exhausted time and exhaustive exhausted distance in forced exercise wheel-track treadmill and treadmill running and motor-driven wheel-track treadmill experiments at 5,800 m (5,000 m) for 3 or 21 days or 21 days , to evaluate changes of physical functions. Rats were also evaluated for times of active escape , and average time of active escape , time of passive escape, and average time of passive escape in a shuttle-box experiment at 5,800 m for 7 days or 28 days 7 or 28 days , to evaluate changes of cognitive learning and memory function s . ATP level was evaluated measured in the gastrocnemius muscle and maloaldehyde (MDA), superoxide dismutase (SOD), hydrogen peroxide (H 2 O 2 ), lactate, and glutathione peroxiase (GSH-Px) measurements and routine blood tests were detected in serum of rats . Results: Survival analysis in 10,000 m indicated NBP could improve hypoxia tolerance ability. Exhaustive Exhausted time for rats (NBP, 120 and 240 mg/kg) and exhaustive exhausted time and distance for mice (NBP, 90 mg/kg) significantly increased under acute hypoxia. And NBP treatment also significantly increased the exhaustive exhausted time for rats under chronic hypoxia. Moreover, NBP of 120 and 240 mg/kg significantly increased the average time s of passive active escape under acute and chronic hypoxia. These results suggested that NBP could improve physical and cognitive learning and memory functions under acute and chronic hypobaric hypoxia. Furthermore, the levels of MDA and H 2 O 2 decreased but those of SOD and GSH-Px in serum of rats increased under acute and chronic hypoxia. Furthermore, Additionally, the content of ATP in gastrocnemius muscle significantly increased, while lactate in serum level significantly decreased. The results presented suggested that NBP could regulate redox homeostasis and improve energy metabolism of hypobaric hypoxic rats. Conclusion: NBP could improve physical and cognitive learning and memory functions under acute and chronic hypobaric hypoxia by increasing anti-oxidative capacity and energy supply.

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Section: Discussionmentioning

confidence: 88%

DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia

Shi

Sun

et al. 2020

Preprint

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“…The present study is the first to assess gCBF after acclimatization to altitude with and without the use of antioxidants. There are well‐reported elevations in oxidative stress with normobaric (Irarrázaval et al., ) and hypobaric hypoxia (Bailey et al., ; Lewis et al., ). Therefore, it is reasonable to hypothesize that this increase in oxidative stress might, in part, be responsible for the alternations in cerebral vascular function at high altitude (Jensen, Sperling, Severinghaus, & Lassen, ).…”

Section: Discussionmentioning

confidence: 97%

“…Elevated markers of oxidative stress are evident in both acute (Irarrázaval et al., ) and chronic hypoxia (Lewis et al., ), which may lead to a reduction in nitric oxide (NO) bioavailability through the interaction of NO and superoxide (i.e. free radical [O 2 − ]) to form peryoxynitrite (O 2 − + NO = ONOO − ; Meli, Nauser, Latal, & Koppenol, ; Thomas, Witting, & Drummond, ).…”

Section: Introductionmentioning

confidence: 99%

UBC‐Nepal expedition: The use of oral antioxidants does not alter cerebrovascular function at sea level or high altitude

Hansen

Hoiland

Lewis

et al. 2018

Experimental Physiology

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Hypoxia is associated with an increase in systemic and cerebral formation of free radicals and associated reactants that may be linked to impaired cerebral vascular function and neurological sequelae. To what extent oral antioxidant prophylaxis impacts cerebrovascular function in humans throughout the course of acclimatization to the hypoxia of terrestrial high altitude has not been examined. Thus, the purpose of the present study was to examine the influence of orally ingested antioxidants at clinically relevant doses (vitamins C and E and α-lipoic acid) on cerebrovascular regulation at sea level (344 m; n = 12; female n = 2 participants) and at high altitude (5050 m; n = 9; female n = 2) in a randomized, placebo-controlled and double-blinded crossover design. Hypercapnic and hypoxic cerebrovascular reactivity tests of the internal carotid artery (ICA) were conducted at sea level, and global and regional cerebral blood flow (CBF; i.e. ICA and vertebral artery) were assessed 10-12 days after arrival at 5050 m. At sea level, acute administration of antioxidants did not alter cerebral hypoxic cerebrovascular reactivity (pre versus post: 1.5 ± 0.7 versus 1.2 ± 0.8%∆CBF/-%∆SpO2; P = 0.96) or cerebral hypercapnic cerebrovascular reactivity (pre versus post: 5.7 ± 2.0 versus 5.8 ± 1.9%∆CBF/∆mmHg; P = 0.33). Furthermore, global CBF (P = 0.43) and cerebral vascular conductance (ICA P = 0.08; vertebral artery P = 0.32) were unaltered at 5050 m after antioxidant administration. In conclusion, these data show that an oral antioxidant cocktail known to attenuate systemic oxidative stress failed to alter cerebrovascular function at sea level and CBF during acclimatization to high altitude.

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“…The relationship between oxidative stress and AMS severity has also been suggested. [15][16][17] Releases of both inflammatory mediators and ROS would lead to the disruption of blood brain barrier (BBB), inducing the capillary leakage and finally causing the cerebral edema (BBB theory). 3 As the leading cells in host response, neutrophils undoubtedly play an important role in the complex networks.…”

Section: Discussionmentioning

confidence: 99%

Physiological Variables Associated with the Development of Acute Mountain Sickness

Liu

Guo

et al. 2019

Chinese Medical Sciences Journal

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Objective To identify the physiological variables associated with the development of acute mountain sickness (AMS). Methods 84 young Chinese men residing at low altitude were taken to an elevation of 4000 m within 40 hours. At sea level and at altitude, the heart rate, blood pressure, and peripheral oxygen saturation (SpO2) were measured respectively. We also collect blood samples from each participants before and after their elevation. The blood routine and biochemical examinations were performed for all blood samples. The revised Lake Louise Criteria was adopted to diagnose AMS after arrived at the target high altitude. We assessed the association between the presence of AMS and subjects' physiological variables. Results Of 84 participants, 34 (40.5%) developed AMS. Compared with non AMS group, in the AMS group, the percentage of neutrophils was significantly higher (64.5%± 11.2% vs 58.1%± 8.8%, P =0.014), while the level of SpO2 was significantly lower (79.4%± 5.4% vs 82.7%± 5.6, P=0.008). Binary logistic regression analyses emphasized the association of neutrophils (OR: 1.06, 95% CI: 1.01-1.12, P=0.034) and SpO2 level (OR: 0.87, 95% CI : 0.79-0.95, P=0.004) with the development of AMS. Conclusion The ability to sustain SpO 2 after altitude elevation and the increase of neutrophils were associated with the development of AMS in young males. Due to improved accessibility, there has been an increasing number of visitors in high-altitude areas. People who have not acclimatized to high altitude yet ascend to altitude higher than 2500m in a short period are prone to acute high-altitude illness, a collective term for acute mountain sickness (AMS), high-altitude cerebral edema (HACE), and high-altitude pulmonary edema (HAPE). Among these high-altitude illnesses, AMS is the most common form, which generally occurs within 6 to 12 hours after high altitude exposure. The prevalence of AMS can reach 10% at 2500 m and increase with altitude. 1 Common symptoms of AMS consist of headache, dizziness, gastrointestinal symptoms, fatigue, and controversial sleep disturbance. 2 Although undoubtedly it is the acute exposure to hypoxia that triggers AMS, the exact process is unclear. 3 Objective variables correlated with AMS has been studied in the past decade, for they could provide hints of possible mechanisms and allow objective assessment. However, none of these objective variables were well acknowledged, and AMS is still a clinical diagnosis relying on questionnaires. The Lake Louise Questionnaire has been revised to a new version in 2018. 2 In this study, we

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Oxidative Stress in Acute Hypobaric Hypoxia

Cited by 51 publications

References 26 publications

DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia

DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia

UBC‐Nepal expedition: The use of oral antioxidants does not alter cerebrovascular function at sea level or high altitude

Physiological Variables Associated with the Development of Acute Mountain Sickness

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