Oxidative Stress in Acute Coronary Syndrome

Abstract

Oxidative stress and free radicals are known to have important roles in the development of atherosclerosis, which is the underlying cause of acute coronary syndrome (ACS). Malondialdehyde (MDA), a carbonile group produced during lipid peroxidation, is used widely in determining oxidative stress. This study of oxidative stress is in terms of Malondialdehyde (MDA) and total antioxidant capacity (TAC). MATERIALS AND METHODS: Study group comprised of 114 patients diagnosed as having ACS based on clinical and bio-chemical criteria. Control group included 66 age and sex matched subjects (Non ACS cases) using the same criteria. RESULTS: In this study, significant increase of mean values of serum MDA and significant decrease in TAC level was observed in ACS cases when compared with controls. CONCLUSION: Oxidative stress is markedly observed in ACS cases, MDA increased and TAC is decreased.