Oxidative stress, glutathione, and gene expression as key indicators in SH-SY5Y cells exposed to zearalenone metabolites and beauvericin

Agahi, Fojan; Álvarez-Ortega, Neda; Font, Guillermina; Juan-García, Ana

doi:10.1016/j.toxlet.2020.09.011

Cited by 27 publications

(9 citation statements)

References 59 publications

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“…Environmental stressors can immediately stimulate oxidative stress via a complex physiological process, and oxidative stress occurs when the level of reactive oxygen species (e.g., O 2 − , H 2 O 2 , OH, etc.) is higher than the scavenging activities of antioxidants [40,41]. SOD can scavenge O 2 − and catalyze it to O 2 and H 2 O 2 [34].…”

Section: Discussionmentioning

confidence: 92%

Mixture toxic impacts and the related mechanism of aflatoxin B1 and deoxynivalenol on embryonic zebrafish (Danio rerio)

Wang

Chun³

et al. 2021

Environ Sci Eur

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Background Although humans and animals are often simultaneously exposed to a variety of mycotoxins via feed and food consumption, in which aflatoxin B1 (AFB1) and deoxynivalenol (DON) is one of the most prevalent combination of mycotoxins. Many toxicological studies have merely focused on the impacts of single mycotoxins. In the present study, the combined toxicity and the related mechanism of AFB1 and DON to zebrafish (Danio rerio) were investigated. Results Results exhibited that DON had lower toxicity to embryonic zebrafish with a 7-day LC50 of 218.3 mg a.i. L−1 in comparison to AFB1 (0.031 mg a.i. L−1). The mixture of AFB1 and DON elicited an additive combined effect on zebrafish embryos. The levels of CAT, caspase-3, and T4 markedly varied in most single and mixture groups. The expressions of four genes (cas3, apaf-1, cc-chem, and cyp19a) associated with oxidative stress, cellular apoptosis, immune system, and endocrine system were markedly varied upon the mixture exposure in comparison to the corresponding single exposure of AFB1 or DON. Conclusions Our results revealed that the impacts of a mixture could not be estimated solely based on toxicities of the single mycotoxins. Taken together, our comprehensive investigation on the mycotoxin mixtures and their potential mechanisms could better reflect the reality of mycotoxin contamination in food and feed.

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Section: Discussionmentioning

confidence: 92%

Mixture toxic impacts and the related mechanism of aflatoxin B1 and deoxynivalenol on embryonic zebrafish (Danio rerio)

Wang

Chun³

et al. 2021

Environ Sci Eur

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“…Environmental stressors can immediately stimulate oxidative stress via a complex physiological process, and oxidative stress occurs when the level of reactive oxygen species ( e.g., O 2 • − , H 2 O 2 , •OH, etc.) is higher than the scavenging activities of antioxidants [40]. The antioxidants, including SOD, CAT, and POD, can protect the cells from oxidative stress through their important role in the defense mechanism [41] [34].…”

Section: Discussionmentioning

confidence: 95%

Mixture Toxic Impacts and the Related Mechanism of Aflatoxin B1 and Deoxynivalenol on Embryonic Zebrafish (Danio Rerio)

Wang

Chun³

et al. 2021

Preprint

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BackgroundAlthough humans and animals are often simultaneously exposed to a variety of mycotoxins via feed and food consumption, in which aflatoxin B1 (AFB1) and deoxynivalenol (DON) is one of the most prevalent combination of mycotoxins. Many toxicological reports have merely focused on the impacts of single mycotoxins. In the present study, the combined toxicity and the related mechanism of AFB1 and DON to zebrafish (Danio rerio) were investigated. ResultsWe showed that DON had lower toxicity to embryonic zebrafish with a 7-day LC50 of 218.3 mg a.i. L-1 in comparison to AFB1 (0.031 mg a.i. L-1). The mixture of AFB1 and DON elicited an additive combined effect on zebrafish embryos. The levels of CAT, caspase-3, and T4 markedly varied in most single and mixture groups. The expressions of four genes (cas3, apaf-1, cc-chem, and cyp19a) associated with oxidative stress, cellular apoptosis, immune system, and endocrine system were markedly varied upon the mixture exposure in comparison to the corresponding single exposure of AFB1 or DON.ConclusionsOur results demonstrate that the impacts of a mixture could not be estimated solely based on toxicities of the single mycotoxins. Taken together, our comprehensive investigation on the mycotoxin mixtures and their potential mechanisms could better reflect the reality of mycotoxin contamination in food and feed.

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“…Elevated levels of calcium ions in the cells activate caspase-3 through the release of cytochrome C and lead to apoptosis [ 137 , 140 , 141 ]. ENNs and BEA also have cytotoxic effects as a result of the induction of oxidative stress [ 142 , 143 ]. Following oral exposure of rats to a mixture of enniatin’s A, A1, B and B1, a change in the expression of genes responsible for the antioxidative protection, genes of suppressor proteins, as well as electron carriers (NADPH) was observed in their stomach, kidney, liver and intestinal cells.…”

Section: Toxicologymentioning

confidence: 99%

Recent Research on Fusarium Mycotoxins in Maize—A Review

Bryła

Pierzgalski

Zapaśnik

et al. 2022

Foods

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Maize (Zea mays L.) is one of the most susceptible crops to pathogenic fungal infections, and in particular to the Fusarium species. Secondary metabolites of Fusarium spp.—mycotoxins are not only phytotoxic, but also harmful to humans and animals. They can cause acute or chronic diseases with various toxic effects. The European Union member states apply standards and legal regulations on the permissible levels of mycotoxins in food and feed. This review summarises the most recent knowledge on the occurrence of toxic secondary metabolites of Fusarium in maize, taking into account modified forms of mycotoxins, the progress in research related to the health effects of consuming food or feed contaminated with mycotoxins, and also the development of biological methods for limiting and/or eliminating the presence of the same in the food chain and in compound feed.

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Oxidative stress, glutathione, and gene expression as key indicators in SH-SY5Y cells exposed to zearalenone metabolites and beauvericin

Cited by 27 publications

References 59 publications

Mixture toxic impacts and the related mechanism of aflatoxin B1 and deoxynivalenol on embryonic zebrafish (Danio rerio)

Mixture toxic impacts and the related mechanism of aflatoxin B1 and deoxynivalenol on embryonic zebrafish (Danio rerio)

Mixture Toxic Impacts and the Related Mechanism of Aflatoxin B1 and Deoxynivalenol on Embryonic Zebrafish (Danio Rerio)

Recent Research on Fusarium Mycotoxins in Maize—A Review

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