Oxidative Stress Genes and Proteins: Fire Alarms and Fire Extinguishers

Ma, Muchou; Eaton, John W.

doi:10.1016/b978-0-08-041749-3.50007-3

Oxidative Damage &Amp; Repair 1991

DOI: 10.1016/b978-0-08-041749-3.50007-3

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Oxidative Stress Genes and Proteins: Fire Alarms and Fire Extinguishers

Muchou Ma

John W. Eaton

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1995

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Cited by 2 publications

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“…To understand this, it has to be appreciated that living organisms including humans can be thought of as resembling "slow-burning engines." 5 The oxidative processes required to burn fuel molecules are carried out in a reducing environment that acts as a "cooling system"-engines have to be cooled to prevent self-destruction.…”

mentioning

confidence: 99%

Unraveling the genetic basis of contact allergy. Will this lead to a better understanding of inter‐individual susceptibility?

Schmidt¹

2021

Contact Dermatitis

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mentioning

confidence: 99%

Unraveling the genetic basis of contact allergy. Will this lead to a better understanding of inter‐individual susceptibility?

Schmidt¹

2021

Contact Dermatitis

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Heme oxygenase-1 mRNA levels, metallothionein mRNA levels, lipid peroxidation and microsomal CYP1A activities in rats treated with 3,3-dichlorobenzidine and some other inducers of P450

Iba

Alam

1995

Redox Report

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The effect of 3,3-dichlorobenzidine (DCB), a potent inducer of CYP1A, on the levels of heme oxygenase-1 mRNA and metallothionein mRNAs was examined in the kidney, liver and lung of rats administered a single ip dose (157 μmol/kg) of the compound. DCB treatment increased heme oxygenase-I mRNA abundance in the kidney significantly from barely detectable levels in untreated animals; the maximum increase in the liver and lung was 24-fold and 4-fold, respectively. Hepatic microsomal heme oxygenase activity was also induced by DCB. In contrast with DCB, 2 other P450 inducers, β-naphthoflavone (β-NF) and phenobarbital did not elevate tissue HO-1 rnRNA levels. DCB pretreatment also elevated metallothionein mRNA levels in the kidney, liver and lung, with the effect in the lung being the least pronounced. In contrast with HO-1 mRNA, metallothionein mRNA was increased by the other P450 inducers examined. In vivo lipid peroxidation and in vitro NADPH-dependent microsomal lipid peroxidation were increased in the liver of DCB-treated rats but not in those of phenobarbital- or β-naphthoflavone-treated rats. Treatment with DCB or β-NF did not alter total hepatic microsomal P450 content, as measured spectrophotometrically, but induced the activity of CYP1A2. In contrast, the activity of CYP1A1 was induced to a lesser extent by DCB than by β-NF. The data show that DCB induces HO-1 as weD as P450 1A, confirm stimulation of lipid peroxidation by the compound, and suggest oxidative stress as a mechanism of HO-1 induction by the compound.

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Oxidative Stress Genes and Proteins: Fire Alarms and Fire Extinguishers

Cited by 2 publications

References 22 publications

Unraveling the genetic basis of contact allergy. Will this lead to a better understanding of inter‐individual susceptibility?

Unraveling the genetic basis of contact allergy. Will this lead to a better understanding of inter‐individual susceptibility?

Heme oxygenase-1 mRNA levels, metallothionein mRNA levels, lipid peroxidation and microsomal CYP1A activities in rats treated with 3,3-dichlorobenzidine and some other inducers of P450

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