Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets

Yu, Mengsi; Wang, Zhiying; Wang, Dongmin; Aierxi, Milikemu; Ma, Zhanjun; Wang, Yonggang

doi:10.1002/jnr.25221

Cited by 20 publications

(9 citation statements)

References 163 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ferrous ions can participate in the aforementioned lipid peroxidation through Fenton reaction, generating a large amount of ROS, thereby causing secondary lipid peroxidation and further exacerbating oxidative stress ( 33 ). ROS can also react with C-H, S-H, N-H, or O-H in proteins, mediating the cleavage of peptide chains and modification of amino acid side chains, leading to protein misfolding, altered protein function, and increased susceptibility to hydrolysis and degradation ( 34 ). Experimental study ( 35 ) have shown that after SCI, proteins in the spinal cord are easily oxidized by oxidants to form advanced oxidation protein products.…”

Section: The Relationship Between Sci With Oxidative Stressmentioning

confidence: 99%

Research progress on the inhibition of oxidative stress by teriparatide in spinal cord injury

Ai,

Xiong,

Deng

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

Spinal cord injury (SCI) is currently a highly disabling disease, which poses serious harm to patients and their families. Due to the fact that primary SCI is caused by direct external force, current research on SCI mainly focuses on the treatment and prevention of secondary SCI. Oxidative stress is one of the important pathogenic mechanisms of SCI, and intervention of oxidative stress may be a potential treatment option for SCI. Teriparatide is a drug that regulates bone metabolism, and recent studies have found that it has the ability to counteract oxidative stress and is closely related to SCI. This article summarizes the main pathological mechanisms of oxidative stress in SCI, as well as the relationship between them with teriparatide, and explores the therapeutic potential of teriparatide in SCI.

show abstract

Section: The Relationship Between Sci With Oxidative Stressmentioning

confidence: 99%

Research progress on the inhibition of oxidative stress by teriparatide in spinal cord injury

Ai,

Xiong,

Deng

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…Emerging data have shown that the depletion of KDM6A promotes intrinsic neural regeneration, vascular regeneration, and neural repair, thus benefiting functional recovery post SCI [ [20] , [21] , [22] ]. The imbalance between ROS and antioxidants participates in the functional and pathological impairment after SCI [ 23 ]. NADPH oxidases are a vital source for ROS, and NOX4 is a member of the NADPH oxidase family and plays a driving role in apoptosis, ROS production, and inflammatory responses post SCI [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic mechanism of miR-26b-5p-enriched MSCs-EVs attenuates spinal cord injury

Xu,

Ren,

Niu

et al. 2024

Regenerative Therapy

View full text Add to dashboard Cite

“…The free ion is then able to readily generate reactive oxygen species (ROS) by way of the Fenton reaction [32]. ROS and cytokine signaling drive the inflammatory process towards an apoptotic state [33].…”

mentioning

confidence: 99%

Astrogliosis: A review of the astrocytic mechanisms, imaging modes, and treatments in spinal cord injury patients

Nguyen,

Godbole

et al. 2024

ATM

View full text Add to dashboard Cite

Astrocytes are cells in the central nervous system (CNS) that are responsible for many things, such as maintaining blood brain barrier (BBB), regulating synapses in the spinal cord, and responding to spinal cord injury (SCI). Astrogliosis, the astrocytic response to spinal cord injuries (SCIs), helps repair CNS damages by regulating different protein filaments, thus limiting axonal growth. Former studies that were demonstrated through laser capture microdissection and immunohistochemistry (IHC) helped to identify important genes involved in experimental therapies for SCIs. Additionally, there are potential clinical treatments options for SCIs such as hydrogels, mesenchymal stem cells and steroids. Increased imaging modalities indicate that excessive astrogliosis can have adverse effects. These imaging techniques include positron emission tomography (PET), magnetic resonance imaging (MRI), and two-photon laser-scanning microscopy (TPLSM). These techniques illuminate greater details of the astrocytic response to SCIs. Despite these findings, astrogliosis is not well understood by the research community. Many of the studies presented in this literature review are experimental attempts to understand the mechanisms of astrogliosis in SCIs. This literature review aims to summarize the methods of each study in visualizing the mechanisms of astrogliosis and how they play a role in SCIs. Furthermore, this paper is aimed to comprehensively bridge the developments in the treatment for SCI patients based on innovative imaging modalities. Compared to prior studies, this review utilizes more recent understandings of the astrogliosis mechanisms to highlight insights into targeted developments, both clinically and preclinically. Some limitations of this literature review include the limited studies on astrogliosis and its impact on SCIs. Nonetheless, there is ongoing potential in the search for treatments for SCIs.

show abstract

Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets

Cited by 20 publications

References 163 publications

Research progress on the inhibition of oxidative stress by teriparatide in spinal cord injury

Research progress on the inhibition of oxidative stress by teriparatide in spinal cord injury

Epigenetic mechanism of miR-26b-5p-enriched MSCs-EVs attenuates spinal cord injury

Astrogliosis: A review of the astrocytic mechanisms, imaging modes, and treatments in spinal cord injury patients

Contact Info

Product

Resources

About