Oxidative stress early in pregnancy and pregnancy outcome

Stein, T. P.; Scholl, Theresa O.; Schluter, M. D.; Leskiw, M. J.; Chen, Xinhua; Spur, Bernd W.; Rodrı́guez, Ana R.

doi:10.1080/10715760802510069

Cited by 131 publications

(78 citation statements)

References 41 publications

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“…22 Another study (N=503) measured 8-isoprostane in maternal plasma collected once between 24–26 weeks gestation and observed higher levels in mothers who developed preeclampsia or had small for gestational age infants. 20 Neither group observed an association with PTB, though the number of cases in each study was small (N=48 and 37, respectively).…”

Section: Commentmentioning

confidence: 99%

Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth

Ferguson

McElrath

Chen

et al. 2015

American Journal of Obstetrics and Gynecology

108

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Objective To investigate oxidative stress as a mechanism of preterm birth in human subjects, we examined associations between urinary biomarkers of oxidative stress measured at multiple time points during pregnancy and preterm birth. Study Design This nested case-control study included 130 mothers who delivered preterm and 352 who delivered term who were originally recruited as part of an ongoing prospective birth cohort at Brigham and Women’s Hospital. Two biomarkers, including 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane were measured in urine samples collected at up to four time points (median 10, 18, 26, and 35 weeks) during gestation. Results Urinary concentrations of 8-isoprostane and 8-OHdG decreased and increased, respectively, as pregnancy progressed. Average levels of 8-isoprostane across pregnancy were associated with increased odds of spontaneous preterm birth (adjusted odds ratio [aOR]=6.25, 95% confidence interval [CI]=2.86, 13.7), and associations were strongest with levels measured later in pregnancy. Average levels of 8-OHdG were protective against overall preterm birth (aOR=0.19, 95%CI=0.10, 0.34), and there were no apparent differences in the protective effect in cases of spontaneous preterm birth compared to cases of placental origin. Odds ratios for overall preterm birth were more protective in association with urinary 8-OHdG concentrations measured early in pregnancy. Conclusions Maternal oxidative stress may be an important contributor to preterm birth, regardless of subtype and timing of exposure during pregnancy. The two biomarkers measured in the present study had opposite associations with preterm birth; an improved understanding of what each represents may help to more precisely identify important mechanisms in the pathway to preterm birth.

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Section: Commentmentioning

confidence: 99%

Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth

Ferguson

McElrath

Chen

et al. 2015

American Journal of Obstetrics and Gynecology

108

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“…Increased oxidative stress in human pregnancy has also been implicated in the pathogenesis of preeclampsia [14-15], preterm birth [16], intrauterine growth retardation [14, 17] and low birth weight deliveries [18]. Stein et al [16] recently reported that elevated urine 8-OHdG concentrations measured in early pregnancy were associated with reduced infant birthweight and with shortened length of gestation.…”

Section: Introductionmentioning

confidence: 99%

“…Stein et al [16] recently reported that elevated urine 8-OHdG concentrations measured in early pregnancy were associated with reduced infant birthweight and with shortened length of gestation. To our knowledge, no previous study has examined the extent to which, if at all, maternal urinary 8-OHdG in early pregnancy may be related with incident gestational diabetes mellitus (GDM).…”

Section: Introductionmentioning

confidence: 99%

Oxidative DNA damage in early pregnancy and risk of gestational diabetes mellitus: A pilot study

Qiu

Hevner

Abetew

et al. 2011

Clinical Biochemistry

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OBJECTIVES To examine the association of maternal early pregnancy oxidative stress with risk of gestational diabetes mellitus (GDM). DESIGN AND METHODS A pilot prospective, nested case-control study was conducted. Study participants were recruited before 20 weeks gestation. Maternal urinary 8-hydroxydeoxyguanosine (8-OHdG), a biomarker of systemic oxidative DNA damage and repair, was measured using competitive immunoassays. Logistic regression was used to calculate odds ratio (OR) and 95% confidence intervals (95%CI). RESULTS Elevations in early pregnancy urinary 8-OHdG concentrations were associated with increased GDM risk. After adjusting for confounders, the OR for extreme quartiles (≥8.01 vs. <4.23ng/mg creatinine) of 8-OHdG was 3.79 (95%CI 1.03-14.00). The risk for GDM was highest for overweight women with urine 8-OHdG concentrations ≥ 8.01ng/mg creatinine (OR=5.36, 95%CI 1.33-21.55) when compared with lean women who had 8-OHdG concentrations < 8.01ng/mg creatinine. CONCLUSIONS Elevated urine 8-OHdG concentrations in early pregnancy appear to be associated with increased GDM risk.

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“…Indeed, high levels of 8-OHdG in placental DNA or urine from pre-eclamptic women have been reported, although other studies have described no significant change [Takagi et al 2004;Hung et al 2010;Peter Stein et al 2008]. In our current study, we examined the levels of 8-OHdG in pre-eclamptic placental tissue in the context of IDO expression to further evaluate the significance of the antioxidant function of IDO in this disorder.…”

Section: Introductionmentioning

confidence: 99%

Impact of indoleamine 2,3-dioxygenase on the antioxidant system in the placentas of severely pre-eclamptic patients

Nishizawa¹,

Suzuki²,

Pryor-Koishi³

et al. 2011

Systems Biology in Reproductive Medicine

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Indoleamine 2,3-dioxygenase (IDO) is the rate limiting enzyme of the kynurenine pathway that degrades L-tryptophan, but a wider range of functions have now been proposed for this enzyme, including antioxidant activity. Our previous study revealed that reduced IDO expression in the placenta induces defective feto-maternal immuno-tolerance leading to the onset of pre-eclampsia. In our present study, we assessed the effects of low placental IDO activity as an antioxidant. The placental levels of 8-hydroxy-2'-deoxy-guanosine (8-OHdG), a maker for oxidative damage to DNA, were significantly higher in pre-eclamptic than normotensive pregnancies (P < 0.05). Immunohistochemical signals of 8-OHdG were detected mainly in syncytiotrophoblasts and vascular endothelial cells, and colocalized with those for IDO. Furthermore, a significant inverse correlation was found between the IDO activity and 8-OhdG levels. These results show that oxidative stress is associated with decreased IDO activity in the pre-eclamptic placenta and suggest an impact of low IDO activity other than immune modulation in promoting the onset of this disorder.

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Oxidative stress early in pregnancy and pregnancy outcome

Cited by 131 publications

References 41 publications

Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth

Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth

Oxidative DNA damage in early pregnancy and risk of gestational diabetes mellitus: A pilot study

Impact of indoleamine 2,3-dioxygenase on the antioxidant system in the placentas of severely pre-eclamptic patients

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