Oxidative stress, chronic inflammation, and telomere length in patients with periodontitis

Masi, Stefano; Salpea, Klelia D.; Li, Kawa; Parkar, MH; Nibali, Luigi; Donos, Nikos; Patel, Kalpesh; Taddei, Stefano; Deanfield, John; D’Aiuto, Francesco; Humphries, Steve E.

doi:10.1016/j.freeradbiomed.2010.12.031

Cited by 97 publications

(101 citation statements)

References 36 publications

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“…We reported increased levels of systemic inflammation/oxidative stress to be associated with both diagnosis of periodontitis and shorter LTL (13). In this study, we documented that these associations are present also in individuals suffering from diabetes, a disorder characterized by a chronic state of increased inflammation and oxidative stress, and we suggested the bacterial burden as a possible factor accounting for this association.…”

Section: Discussionsupporting

confidence: 58%

Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey

Masi

Gkranias

et al. 2014

Diabetes Care

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OBJECTIVEShortened leukocyte telomere length (LTL) and diagnosis of periodontitis are associated with an increased risk of complications and mortality in diabetes. This study investigated the association between LTL, endotoxemia, and severity of periodontitis in a large cohort of people with diabetes. RESEARCH DESIGN AND METHODSSix hundred thirty individuals (371 with type 2 and 259 with type 1 diabetes) were recruited from the University College Hospital in London, U.K. During a baseline visit, blood was collected for standard biochemical tests and DNA extraction, while a dental examination was performed to determine diagnosis and extent of periodontitis. LTL was measured by real-time PCR, and endotoxemia was assessed by the limulus amoebocyte lysate method. RESULTSTwo hundred fifty-five individuals were diagnosed with gingivitis, 327 with periodontitis (114 with moderate and 213 with severe disease), and 48 with edentulous. Diagnosis of periodontitis was associated with shorter LTL (P = 0.04). A negative association between LTL and endotoxemia was found in the severe periodontitis and type 2 diabetes groups (P = 0.01 for both). Shorter LTL was associated with increased extent of periodontitis (P = 0.01) and increased insulin resistance (homeostatic model assessment). Multiple adjustments for biochemical, anthropometric, and medication-use variables did not affect the results. CONCLUSIONSLTL is associated with endotoxemia and diagnosis of periodontitis in people with diabetes. LTL shortening might represent a novel biological pathway accounting for previous epidemiological data that documented higher prevalence of diabetes and its complications in people with periodontitis and vice versa.

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Section: Discussionsupporting

confidence: 58%

Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey

Masi

Gkranias

et al. 2014

Diabetes Care

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“…Interestingly, it has been shown that chronic inflammation is associated with up to one fourth of cancers and also may speed up telomere attrition. [33][34][35] Therefore, it is possible that chronic inflammation can partially illuminates the association between rs398652 and telomere length as well as ESCC risk. Although rs621559 locates in intron 2 of the WDR65 gene, there is no report showing WDR65's relevance in either telomere maintenance or cancer development.…”

Section: Discussionmentioning

confidence: 99%

Leukocyte telomere length‐related genetic variants in 1p34.2 and 14q21 loci contribute to the risk of esophageal squamous cell carcinoma

Shi

Sun²,

et al. 2012

Intl Journal of Cancer

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Short leukocyte telomere length has been associated with significantly increased risk of esophageal cancer. A previous genomewide association study demonstrated that four SNPs (rs398652 on 14q21, rs621559 on 1p34.2, rs6028466 on 20q11.22 and rs654128 on 6q22.1) were associated with leukocyte telomere length in Caucasians. However, the role of these genetic variants on esophageal squamous cell carcinoma (ESCC) susceptibility is still unknown. Therefore, we investigated whether these polymorphisms have impact on leukocyte telomere length and the risk of ESCC in Chinese. After measuring leukocyte telomere length of 550 healthy individuals, we observed that both rs621559 and rs398652 genetic variants are significantly associated with leukocyte telomere length. On the basis of analyzing 1550 ESCC patients and frequency-matched 1620 controls from 4 medical centers in China, we found that 0.71-fold decreased risk of ESCC is associated with the rs621559 AA genotype compared with the rs621559 GG genotype (p 5 5.9 3 10 26 ). We also detected a moderately increased OR for ESCC that was associated with the 14q21 rs398652 G allele (p 5 6.5 3 10 24 ). It has been shown that both rs621559 and rs398652 polymorphisms were significantly associated with ESCC risk in additive, recessive or dominant genetic models. Stratified analyses demonstrated that these associations were more pronounced in males. Our results highlight the complexity of genetic regulation of telomere length and further support the important role of telomere in carcinogenesis.

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“…The same group, in a smaller cross-sectional study, had observed no difference in plasma TAOC between chronic periodontitis and healthy subjects as measured by enhanced chemiluminescence [ 50 ]. Systemic reductions in TAOC were also detected in the above-mentioned studies by Masi et al [ 45 ] and Baltacioglu et al [ 41 ]. Using the same assay, TAC (renamed small molecule antioxidant capacity) was found to be lower in the plasma of diabetic patients with periodontitis compared to diabetic patients with healthy periodontia [ 51 ].…”

Section: Systemic Redox Balancementioning

confidence: 65%

“…No telomere length reduction was detected in aggressive periodontitis subjects in this study compared with healthy subjects, rejecting the hypothesis of premature cellular aging in this group of patients. A similar case-control study from our group included 356 periodontitis patients and 207 healthy individuals [ 45 ]. In these subjects, the ratio of telomere repeats to single-copy gene (SCG) copies was obtained by PCR.…”

Section: Dna Damage Caused By Oxidative Stressmentioning

confidence: 99%

Periodontitis and Oxidative Stress: Human Studies

Nibali

Henderson

Volti

et al. 2013

Studies on Periodontal Disease

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Oxidative stress, chronic inflammation, and telomere length in patients with periodontitis

Cited by 97 publications

References 36 publications

Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey

Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey

Leukocyte telomere length‐related genetic variants in 1p34.2 and 14q21 loci contribute to the risk of esophageal squamous cell carcinoma

Periodontitis and Oxidative Stress: Human Studies

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