Oxidative Stress-Based Photodynamic Therapy with Synthetic Sensitizers and/or Natural Antioxidants

Ion, Rodica‐Mariana; Şuică-Bunghez, Ioana-Raluca

doi:10.5772/60872

Cited by 6 publications

(4 citation statements)

References 69 publications

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“…The most commonly used PSs are porphyrins, chlorins, bacteriochlorins, purpurins, metalloporphyrins, phthalocyanines, etc. [ 13 , 14 ]. Chlorin e6 (Ce6) is FDA approved second generation PS, which absorbs red light, characterized with relatively deep tissue penetration, in contrast with first generation PS [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles

et al. 2021

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Pheophorbide a 17-diethylene glycol ester (XL-8), is a promising high-active derivative of known photosensitizer chlorin e6 used in photodynamic therapy. However, high lipophilicity and poor tumor accumulation limit XL-8 therapeutic application. We developed a novel XL-8 loaded with poly(D,L-lactide-co-glycolide) nanoparticles using the single emulsion-solvent evaporation method. The nanoparticles possessed high XL-8 loading content (4.6%) and encapsulation efficiency (87.7%) and a small size (182 ± 19 nm), and negative surface charge (−22.2 ± 3.8 mV) contributed to a specific intracellular accumulation. Sustained biphasic XL-8 release from nanoparticles enhanced the photosensitizer photostability upon irradiation that could potentially reduce the quantity of the drug applied. Additionally, the encapsulation of XL-8 in the polymer matrix preserved phototoxic activity of the payload. The nanoparticles displayed enhanced cellular internalization. Flow cytometry and confocal laser-scanning microscopy studies revealed rapid XL-8 loaded nanoparticles distribution throughout the cell and initiation of DNA damage, glutathione depletion, and lipid peroxidation via reactive oxygen species formation. The novel nanoformulated XL-8 simultaneously revealed a significant phototoxicity accompanied with enhanced photostability, in contrast with traditional photosensitizers, and demonstrated a great potential for further in vivo studies.

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Section: Introductionmentioning

confidence: 99%

Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles

et al. 2021

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“…Aextract=0.5 mL sample + DPPH recent research that analyzed antioxidant properties. [10][11][12][13][14][15][16].…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Silver Nanoparticles Using Hydroalcoholic Extract of Sambucus Nigra and Lavandula Angustifolia

Stirbescu,

Olteanu

et al. 2023

Scientific Bulletin of Valahia University - Materials and Mechanics

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Technique development for getting environmentally friendly nanomaterials was the paper's main goal. Spectroscopic techniques were utilized to characterize the plant extracts used in this work (UV-Vis, FTIR and Raman). In this case, plants from the Valea Voievozilor was processed in a dry state, was used at the ideal moment and at the plant's peak maturation period. Several analytical techniques (UV-Vis, FTIR, Raman analysis) have been used to analyze the nanoparticles (Ag) created with the aid of these plant extracts. Both the bioreduction of silver ions (Ag+ to Ag0) and the stability of silver nanoparticles are caused by the bioactive chemicals found in plant materials.

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“…Also, in the process of ROS and nitric oxide interaction, reactive nitric oxide species (RNS) can be formed as byproducts . Increase in ROS and RNS levels lead to the oxidative stress, resulting in damage to cellular macromolecules (nucleic acids, proteins, and lipids) . Tissue sensitivity to light was first reported by O. Raab in 1900: acridine-stained paramecium dies specifically under sunlight irradiation. , In 1904, H. von Tappeinermin introduced the term “photodynamic therapy” to determine the photochemical reaction with singlet oxygen formation.…”

Section: Therapymentioning

confidence: 99%

Metalloporphyrins in Medicine: From History to Recent Trends

Faustova

Nikolskaya

Sokół

et al. 2020

ACS Appl. Bio Mater.

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The history of metalloporphyrins dates back more than 200 years ago. Metalloporphyrins are excellent catalysts, capable of forming supramolecular systems, participate in oxygen photosynthesis, transport, and used as contrast agents or superoxide dismutase mimetics. Today, metalloporphyrins represent complexes of conjugated π-electron system and metals from the entire periodic system. However, the effect of these compounds on living systems has not been fully understood, and researchers are exploring the properties of metalloporphyrins thereby extending their further application. This review provides an overview of the variety of metalloporphyrins that are currently used in different medicine fields and how metalloporphyrins became the subject of scientists’ interest. Currently, metalloporphyrins utilization has expanded significantly, which gave us an opprotunuty to summarize recent progress in metalloporphyrins derivatives and prospects of their application in the treatment and diagnosis of different diseases.

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Oxidative Stress-Based Photodynamic Therapy with Synthetic Sensitizers and/or Natural Antioxidants

Cited by 6 publications

References 69 publications

Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles

Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles

Synthesis of Silver Nanoparticles Using Hydroalcoholic Extract of Sambucus Nigra and Lavandula Angustifolia

Metalloporphyrins in Medicine: From History to Recent Trends

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