Oxidative Stress Associated with Rapid Weight Reduction Decreases Circulating Adiponectin Concentrations

Yanagawa, Yoshimaro; Morimura, Tadashi; Tsunekawa, Katsuhiko; Seki, Koji; Ogiwara, Takayuki; Kotajima, Nobuo; Machida, Tetsuo; Matsumoto, Shingo; Adachi, Takumi; Murakami, Masami

doi:10.1507/endocrj.k09e-359

Cited by 21 publications

(18 citation statements)

References 32 publications

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“…In 36% of the subjects the dosage of at least one drug was slightly reduced, which would, if anything, have improved micronutrient bioavailability. We did not find statistically significant correlations between vitamin E in serum and BMC, but the decrease in BMC concentrations could point to the fact that intracellular levels respond more sensitively to altered oxidative stress, which particularly occurs in a period of major weight loss [26]. This is explained by an upregulation of the renin-angiotensin system and a reduction of glutathione and glutathione peroxidase in erythrocytes, resulting in higher concentrations of reactive oxygen species which again promote the metabolic syndrome [6].…”

Section: Discussioncontrasting

confidence: 71%

Phosphorus And Nutrition In Chronic Kidney Disease

2013

Clinical Nutrition

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Background: The prevalence of micronutrient deficiencies is higher in obese individuals compared to normalweight people, probably because of inadequate eating habits but also due to increased demands among overweight persons, which are underestimated by dietary reference intakes (DRI) intended for the general population. We therefore evaluated the dietary micronutrient intake in obese individuals compared to a reference population and DRI recommendations. Furthermore, we determined the micronutrient status in obese subjects undergoing a standardized DRI-covering low-calorie formula diet to analyze if the DRI meet the micronutrient requirements of obese individuals. Methods: In 104 subjects baseline micronutrient intake was determined by dietary record collection. A randomly assigned subgroup of subjects (n = 32) underwent a standardized DRI-covering low-calorie formula diet over a period of three months. Pre-and post-interventional intracellular micronutrient status in buccal mucosa cells (BMC) was analyzed, as well as additional micronutrient serum concentrations in 14 of the subjects.

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Section: Discussioncontrasting

confidence: 71%

Phosphorus And Nutrition In Chronic Kidney Disease

2013

Clinical Nutrition

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“…Generation of oxidative stress may even overshadow the beneficial effects of weight loss on adiponectin secretion. In subjects with acute weight reduction, increased urinary excretion of molecules related to oxidative stress was accompanied by a decrease in serum adiponectin (203).…”

Section: Adiponectinmentioning

confidence: 95%

Adipokines and Redox Signaling: Impact on Fatty Liver Disease

Parola

Marra

2011

Antioxidants & Redox Signaling

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Adipokines (adipose tissue cytokines) are polypeptide factors secreted by adipose tissue in a highly regulated manner. The 'classical' adipokines (leptin, adiponectin, and resistin) are expressed only by adipocytes, but other adipokines have been shown to be released by resident and infiltrating macrophages, as well as by components of the vascular stroma. Indeed, adipose tissue inflammation is known to be associated with a modification in the pattern of adipokine secretion. Several studies indicate that adipokines can interfere with hepatic injury associated with fatty infiltration, differentially modulating steatosis, inflammation, and fibrosis. Moreover, plasma levels of adipokines have been investigated in patients with nonalcoholic fatty liver disease in order to establish correlations with the underlying state of insulin resistance and with the type and severity of hepatic damage. In this Forum article, we provide a review of recent data that suggest a significant role for oxidative stress, reactive oxygen species, and redox signaling in mediating actions of adipokines that are relevant in the pathogenesis of nonalcoholic fatty liver disease, including hepatic insulin resistance, inflammation, and fibrosis. Antioxid. Redox Signal. 15, 461-483.

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“…The relationship between adipokines and antioxidant enzyme remains to be elucidated, recent studies have demonstrated that oxidative stress in adipose tissue induces the dysregulated production of adipokines [10] and oxidative stress associated with weight reduction decreases serum adipokines levels [42]. The reason for detraining in obese children is largely unknown relative antioxidant enzymes and adipokines.…”

Section: Introductionmentioning

confidence: 99%

The effects of detraining on blood adipokines and antioxidant enzyme in Korean overweight children

et al. 2011

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The present study examined the change to clarify the effects of detraining on the concentration of lipid profiles, serum adipokines and antioxidant enzyme gene expression in Korean overweight children. The subjects were normal children (n = 19) and obese children (n = 20) who were further subdivided into the overweight training (OT) group (n = 10) and the overweight detraining (OD) group (n = 10). Maximal oxygen uptake (VO(2)max); body composition; lipid profiles (TG, TC); adipokines (adiponectin and leptin); antioxidants (blood and gene expressions SOD and GPX) were measured before, 12 weeks, and 24 weeks after the exercise program. Body mass index (BMI) and %fat were significantly higher in the OD group only. However, waist hip ration (WHR) and systolic blood pressure (SBP) were significantly decreased in the OT group. TG was significantly decreased in the OT group. There was a significant difference in TG level between the two groups. Besides, adiponectin was significantly increased in both the OT group and the OD group. Furthermore, leptin was significantly decreased in the OT group. There was a significant difference in leptin level between the two groups. In training groups, the expression of SOD was significantly increased after a 12- and 24-week period (p < 0.05). However, detraining group was significantly increased after a 12-week only (p < 0.05). In addition, GPX was significantly increased after a 24-week only in the training group (p < 0.05). Thus, detraining showed that negative effected on body composition and lipid profiles and maintained of uniform period on adipokines and antioxidant enzyme the protein and expression.

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Oxidative Stress Associated with Rapid Weight Reduction Decreases Circulating Adiponectin Concentrations

Cited by 21 publications

References 32 publications

Phosphorus And Nutrition In Chronic Kidney Disease

Phosphorus And Nutrition In Chronic Kidney Disease

Adipokines and Redox Signaling: Impact on Fatty Liver Disease

The effects of detraining on blood adipokines and antioxidant enzyme in Korean overweight children

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