Oxidative Stress as Marker of Sepsis in Onco Hematological Patients: A Pilot Study

A, Fracchiolla NS Cortelezzi; C, Orofino N Novembrino

doi:10.4172/2155-9864.1000311

Cited by 1 publication

(3 citation statements)

References 29 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The TAC levels were found to be lower in the follow-up than at the beginning of FEN. The authors thought that the level of reactive oxygen radicals could help to determine the severity of sepsis 7. Different findings from our study may be related with the patient group with leukemia or lymphoma and intensive chemotherapy regimens.…”

Section: Discussioncontrasting

confidence: 61%

“…In these studies, it has been emphasized that there might be a deterioration in the oxidative status after chemotherapy, and it might be related to the severity of sepsis. 6,7 This study aimed to determine the oxidative status of children with FEN to investigate whether it contributes to the determination of risk groups and treatment modifications.…”

mentioning

confidence: 99%

“…There are few studies assessing the oxidative stress in children with or without FEN. In these studies, it has been emphasized that there might be a deterioration in the oxidative status after chemotherapy, and it might be related to the severity of sepsis 6,7…”

mentioning

confidence: 99%

See 2 more Smart Citations

Clinical Utility of Total Oxidative Stress and Total Antioxidant Capacity in Childhood Febrile Neutropenia

Kara

Akyürek²,

Akbas

et al. 2021

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

The aim is to determine the oxidative status of children with febrile neutropenia (FEN). Blood samples were collected to determine the total antioxidant capacity (TAC) and total oxidative status (TOS) of healthy children (once) and children with FEN after 0, 48, and 96 hours. Eighteen patients with FEN were evaluated. The baseline TAC level of patients was significantly higher than that of the controls (P<0.0001). The TAC levels of patients with FEN with and without antibiotic modification were higher than those of the controls (P=0.002 and 0.02, respectively). The TAC levels of the patients with FEN with antibiotic modification were lower than those of the patients without antibiotic modification (P=0.0224). The oxidative stress index (OSI), calculated TOS/TAS, value of the children with FEN was lower than that of the controls (P<0.0001). The OSI values of the patients with FEN with and without antibiotic modification were lower than those of the control group (P=0.001 and <0.0001, respectively). The TAC values of the patients with antibiotic modification were higher than those of the patients without antibiotic modification (P=0.02). In conclusion, the oxidative status of the children with FEN was affected, and it can give information about the follow-up of FEN.

show abstract

Section: Discussioncontrasting

confidence: 61%

mentioning

confidence: 99%