Oxidative stress as an underlying mechanism of anticancer drugs cytotoxicity on human red blood cells' membrane

Mameri, Amal; Bournine, Lamine; Mouni, Lotfi; Bensalem, Sihem; Iguer-Ouada, Mokrane

doi:10.1016/j.tiv.2021.105106

Cited by 14 publications

(6 citation statements)

References 58 publications

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“…Increased oxidative stress status may be caused by many physiopathological and physiological conditions 4 , 23 , nutritional causes 22 , and also from exposure to different external pollutants such as electromagnetic radiation 4 . MDA, a lipid peroxidation end product, is useful for the quantification of oxidative damage 24 and is considered the main and most frequently measured biomarker of oxidative stress 25 . MDA level was shown to be higher in neonates of cesarean delivery 26 , in newborns with congenital anomaly 27 , in coronary artery disease 28 , hyperbilirubinemia 29 cases, in high blood pressure 30 , after bisphenol A (BPA) exposure 31 , in embryos with hyperglycemia and hypoxia 32 , and in prenatal and postnatal exposed female rats to GSM-EMR from their PND 9 11 .…”

Section: Discussionmentioning

confidence: 99%

Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver

Salameh,

Zeitoun-Ghandour,

Sabra

et al. 2023

Sci Rep

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The current study investigated the effects of 24 h/day prenatal exposure to global system for mobile communication electromagnetic fields (GSM-EMFs), 900 MHZ-induced electromagnetic radiation (EMR), on oxidative stress (OS) status, apoptotic, and inflammatory changes in liver of rats during their fetal development period. Fifty-two Sprague–Dawley pregnant rats were equally divided into control and exposed groups. Whole embryos were removed at 7.5 dpc (days post coitus), while liver tissues were extracted from embryos at 11.5, 15.5, and 19.5 dpc. For exposed animals, results showed an increased OS reflected by high levels of malondialdehyde (MDA), a decrease in cytosolic superoxide dismutase (cytoSOD) activity, in mitochondrial superoxide dismutase (mitoSOD) levels and catalase (CAT) mRNA expression but also in hepatic nuclear factor erythroïd 2-related Factor 2 (Nrf-2), protein kinase B (Akt1), and intercellular adhesion molecule-1 (ICAM-1) mRNA expression at 15.5 dpc. Moreover, GSM-EMR exposure was shown to significantly decrease mitoSOD and CAT activities at almost all studied ages. Thus, rat embryos may be protected by their mothers from OS, apoptotic, and pro-inflammatory responses till a sensitive developmental stage, during a continuous prenatal EMR exposure. This protection could be then created from the embryos themselves.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver

Salameh,

Zeitoun-Ghandour,

Sabra

et al. 2023

Sci Rep

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show abstract

“…75 LPO is a chain reaction and an oxidative degradation of lipids and/or fatty acids that results in the loss of membrane fluidity, disruption of membrane integrity and reduction of the cell's antioxidant capacity. 76 Anticancer drugs could inhibit glutathione conjugates and accelerate LPO before causing cytotoxicity. 73 Membrane lipid interactions of anti-cancer drugs could induce ROS and LPO-mediated oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…73 Membrane lipid interactions of anti-cancer drugs could induce ROS and LPO-mediated oxidative stress. 76 Oxidative stress could affect the heart rate which ultimately results in yolk sac oedema and failure in proper supply of nutrients to embryos under chemical insults. 69 Thus, lipophilicity of CP might affect the nutritional delivery/requirement for normal physiological activity, and as a result, physiological and neurological alterations might occur in zebrafish embryos/larvae.…”

Section: Discussionmentioning

confidence: 99%

Developmental toxicity of the emerging contaminant cyclophosphamide and the integrated biomarker response (IBRv2) in zebrafish

Hema¹,

Krishnan²,

Ramesh³

et al. 2023

Environ. Sci.: Processes Impacts

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“…Increased oxidative stress status may be caused by many physiopathological and physiological conditions [21,4], nutritional causes [20], and also from exposure to different external pollutants such as electromagnetic radiation [4]. MDA, a lipid peroxidation end product, is useful for the quanti cation of oxidative damage [22] and is considered the main and most frequently measured biomarker of oxidative stress [23]. MDA level was shown to be higher in neonates of cesarean delivery [24], in newborns with congenital anomaly [25], in coronary artery disease [26], hyperbilirubinemia [27] cases, in embryos with hyperglycemia and hypoxia [28], and in prenatal and postnatal exposed female rats to GSM-EMR from their PND 9 [11].…”

Section: Discussionmentioning

confidence: 99%

Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver

Salameh

Zeitoun-Ghandour

Sabra

et al. 2023

Preprint

View full text Add to dashboard Cite

The current study investigated the effects of 24 hours/day prenatal exposure to global system for mobile communication electromagnetic fields (GSM-EMFs), 900 MHZ-induced electromagnetic radiation (EMR), on oxidative stress (OS) status, apoptotic, and inflammatory changes in liver of rats during their fetal development period. Fifty-two Sprague-Dawley pregnant rats were equally divided into control and exposed groups. Whole embryos were removed at 7.5 dpc (days post coitus), while liver tissues were extracted from embryos at 11.5, 15.5, and 19.5 dpc. For exposed animals, results showed an increased OS reflected by high levels of malondialdehyde (MDA), a decrease in cytosolic superoxide dismutase (cytoSOD) activity, in mitochondrial superoxide dismutase (mitoSOD) levels and catalase (CAT) mRNA expression but also in hepatic nuclear factor erythroïd 2-related Factor 2 (Nrf-2), protein kinase B (Akt1), and intercellular adhesion molecule-1 (ICAM-1) mRNA expression at 15.5 dpc. Moreover, GSM-EMR exposure was shown to significantly decrease mitoSOD and CAT activities at almost all studied ages. Thus, rat embryos may be protected by their mothers from OS, apoptotic, and pro-inflammatory responses till a sensitive developmental stage, during a continuous prenatal EMR exposure. This protection could be then created from the embryos themselves.

show abstract

Oxidative stress as an underlying mechanism of anticancer drugs cytotoxicity on human red blood cells' membrane

Cited by 14 publications

References 58 publications

Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver

Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver

Developmental toxicity of the emerging contaminant cyclophosphamide and the integrated biomarker response (IBRv2) in zebrafish

Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver

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