Oxidative stress as a plausible mechanism for zearalenone to induce genome toxicity

Feng, Yanqin; Zhao, Ai-Hong; Wang, Junjie; Tian, Yu; Yan, Zihui; Dri, Maria; Shen, Wei; Felici, Massimo De; Li, Lan

doi:10.1016/j.gene.2022.146511

Cited by 21 publications

(10 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Obtained results showed that ZEA at concentrations of 10 and 20 mg/kg induced a change in the activity of SOD and GST, with a tendency to increase at higher doses of ZEA. This could be a mechanism to destroy excess ROS caused by ZEA ( Huang et al 2021 , Feng et al 2022 ), and an indication that the enzymes reach their maximum capacity at about 10 mg/kg, so further increasing mycotoxin concentration cannot increase antioxidant protection. It can be concluded that antioxidant enzymes are modulated differently depending on the load caused by mycotoxins ( Yoon et al 2019 , Mavrommatis et al 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…At low levels of contamination, as well as during short exposure routes, mycotoxins can induce antioxidant mechanisms and alter enzymes with antioxidant and/or detoxifying activities. In contrast, longer routes of contamination, or high levels of mycotoxins, can reduce antioxidant defenses, and suppress the expression and activity of antioxidant enzymes ( Mavrommatis et al 2021 , Feng et al 2022 ). First-line antioxidant enzymes such as superoxide dismutase (SOD) and catalase, followed by ascorbate peroxidase and glutathione reductase, which are present in most insect species, provide an efficient system to cope with oxygen free radicals.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of high doses of zearalenone on some antioxidant enzymes and locomotion of Tenebrio molitor larvae (Coleoptera: Tenebrionidae)

Janković-Tomanić,

Petković,

Vranković

et al. 2024

Journal of Insect Science

View full text Add to dashboard Cite

The mealworm Tenebrio molitor L. (Coleoptera: Tenebrionidae) feeds on wheat bran and is considered both a pest and an edible insect. Its larvae contain proteins and essential amino acids, fats, and minerals, making them suitable for animal and human consumption. Zearalenone (ZEA) is the mycotoxin most commonly associated with Fusarium spp. It is found in cereals and cereal products, so their consumption is a major risk for mycotoxin contamination. One of the most important effects of ZEA is the induction of oxidative stress, which leads to physiological and behavioral changes. This study deals with the effects of high doses of ZEA (10 and 20 mg/kg) on survival, molting, growth, weight gain, activity of antioxidant enzymes superoxide dismutase (SOD) and glutathione S-transferase (GST), and locomotion of mealworm larvae. Both doses of ZEA were found to (i) have no effect on survival, (ii) increase molting frequency, SOD, and GST activity, and (iii) decrease body weight and locomotion, with more pronounced changes at 20 mg/kg. These results indicated the susceptibility of T. molitor larvae to high doses of ZEA in feed.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of high doses of zearalenone on some antioxidant enzymes and locomotion of Tenebrio molitor larvae (Coleoptera: Tenebrionidae)

Janković-Tomanić,

Petković,

Vranković

et al. 2024

Journal of Insect Science

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that ZEA affects the activity, number, structure, and function of mitochondria and also affects the electron transport chain [ 35 , 36 , 37 , 38 ]. ZEA-induced mitochondrial damage may be an important pathway for promoting ROS production [ 39 ]. Excessive ROS production causes cellular oxidative stress, leading to an increase in lipid peroxidation products and a decrease in antioxidant indices [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Heme Oxygenase-1 Regulates Zearalenone-Induced Oxidative Stress and Apoptosis in Sheep Follicular Granulosa Cells

Li,

Gao,

Yao

et al. 2024

IJMS

View full text Add to dashboard Cite

Zearalenone (ZEA) is a common non-steroidal estrogenic mycotoxin found in a range of animal feeds and poses a serious threat to the reproductive health of farm animals and humans. However, the mechanism underlying ZEA-induced reproductive toxicity in sheep remains unknown. Granulosa cells are crucial for egg maturation and the fertility of female sheep. In this study, we aimed to examine the impact of different ZEA concentrations on sheep follicular granulosa cells and to elucidate the potential molecular mechanism underlying ZEA-induced toxicity using transcriptome sequencing and molecular biological approaches. Treating primary sheep follicular granulosa cells with different concentrations of ZEA promoted the overproduction of reactive oxygen species (ROS), increased lipid peroxidation products, led to cellular oxidative stress, decreased antioxidant enzyme activities, and induced cell apoptosis. Using transcriptome approaches, 1395 differentially expressed genes were obtained from sheep follicular granulosa cells cultured in vitro after ZEA treatment. Among them, heme oxygenase-1 (HMOX1) was involved in 11 biological processes. The protein interaction network indicated interactions between HMOX1 and oxidative and apoptotic proteins. In addition, N-acetylcysteine pretreatment effectively reduced the ZEA-induced increase in the expression of HMOX1 and Caspase3 by eliminating ROS. Hence, we suggest that HMOX1 is a key differential gene involved in the regulation of ZEA-induced oxidative stress and apoptosis in follicular granulosa cells. These findings provide novel insights into the prevention and control of mycotoxins in livestock.

show abstract

“…It thus acts as nonsteroidal estrogen, disrupting reproductive hormones and testicular development systems regulated by hormone-related genes. ZEN can also induce genotoxicity, hepatotoxicity, immunotoxicity, and cytotoxicity through oxidative damage, endoplasmic reticulum stress, mitochondrial apoptosis, autophagy, and other pathways ( Feng et al., 2022 ; X. Gao et al., 2022 ; Y. Li et al., 2021 ; Zhu et al., 2021 ).…”

Section: Zearalenonementioning

confidence: 99%

Mechanisms by which microbial enzymes degrade four mycotoxins and application in animal production: A review

Sun,

He,

Xiong

et al. 2023

Animal Nutrition

View full text Add to dashboard Cite

Oxidative stress as a plausible mechanism for zearalenone to induce genome toxicity

Cited by 21 publications

References 113 publications

Effects of high doses of zearalenone on some antioxidant enzymes and locomotion of Tenebrio molitor larvae (Coleoptera: Tenebrionidae)

Effects of high doses of zearalenone on some antioxidant enzymes and locomotion of Tenebrio molitor larvae (Coleoptera: Tenebrionidae)

Heme Oxygenase-1 Regulates Zearalenone-Induced Oxidative Stress and Apoptosis in Sheep Follicular Granulosa Cells

Mechanisms by which microbial enzymes degrade four mycotoxins and application in animal production: A review

Contact Info

Product

Resources

About