Oxidative Stress as a Physiological Pain Response in Full‐Term Newborns

Abstract

This research paper aims to investigate if oxidative stress biomarkers increase after a painful procedure in term newborns and if nonpharmacological approaches, or sex, influence pain degree, and the subsequent OS. 83 healthy term newborns were enrolled to receive 10% oral glucose or sensorial saturation (SS) for analgesia during heel prick (HP). The ABC scale was used to score the pain. Advanced oxidation protein products (AOPP) and total hydroperoxides (TH) as biomarkers of OS were measured at the beginning (early-sample) and at the end (late-sample) of HP. The early-sample/late-sample ratio for AOPP and TH was used to evaluate the increase in OS biomarkers after HP. Higher levels of both AOPP and TH ratio were observed in high degree pain (4–6) compared with low degree pain score (0–3) (AOPP: p = 0.049; TH: p = 0.001). Newborns receiving SS showed a significantly lower pain score (p = 0.000) and AOPP ratio levels (p = 0.021) than those without. Males showed higher TH levels at the end of HP (p = 0.005) compared to females. The current study demonstrates that a relationship between pain degree and OS exists in healthy full-term newborns. The amount of OS is gender related, being higher in males. SS reduces pain score together with pain-related OS in the newborns.

The Effect of Liposomal Epigallocatechin Gallate and Metoclopramide Hydrochloride Co-Administration on Experimental Migraine

“…The mechanism involved in these results could be mediated by its ability to reduce the nociception (Table II) that can contribute to oxidative stress modulation. Evidence that pain can induce the increase of oxidative stress, as a physiological response to the nociceptive process exists [26]. Co-administration of EGCG and MC results in improving the oxidative stress/antioxidant status parameters and the nociceptive process, the most efficient results being obtained for L-EGCG administration.…”

Investigation of a Possible Association Between Dynamic Thiol/Disulfide Homeostasis and Pain in Knee Arthroplasty Patients

“…There are several publications in the literature describing the pathophysiological connection between oxidative stress levels and pain. One study indicated that oxidative stress could trigger pain pathways through glutamatergic signaling and activation of inflammatory reactions, as well as by directly affecting nociceptive centers in the brain (Perrone et al, 2017). In another study, it was mentioned that oxidative stress may cause peripheral sensitization; that is, it can change nociception that may cause hyperalgesia (Nashed et al, 2014).…”

Possibilities of arnica D30 for reducing the procedural pain in the neonatal period

“…is preferred as a non-pharmacological alternative due to the proven in clinical neonatological and pediatric practice in the treatment of traumas with hematomas, open wounds, fractures, headache and other conditions accompanied by varying degrees of pain. [21,22]. In addition, Arnica, administered orally in homeopathic dilutions, showed positive clinical effects in the suppression of post-operative pain, edema and ecchymosis.…”