Oxidative stress, antioxidant capacity, biomolecule damage, and inflammation symptoms of sickle cell disease in children

Biswal, Sasmita; Rizwan, Huma; Pal, Sweta; Sabnam, Silpa; Parida, Preetinanda; Pal, Arttatrana

doi:10.1080/10245332.2018.1498441

Cited by 44 publications

(40 citation statements)

References 38 publications

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“…Our study confirms the higher plasma concentrations of global oxidative stress markers (i.e., MDA and AOPP) observed in children with SCA compared to healthy AA controls [ 6 , 11 , 12 , 37 , 38 , 39 ]. MDA and AOPP result from polyunsaturated fatty acid peroxidation and advanced protein oxidation, respectively, and their excessive concentration may reflect reactive oxygen species (ROS) overproduction [ 40 ].…”

Section: Discussionsupporting

confidence: 86%

“…Oxidative stress is enhanced in SCA and would also play a major role in the pathophysiology of the disease by promoting red blood cell (RBC) damage, inflammation, and endothelial-vascular dysfunction [ 1 , 2 , 3 , 4 ]. Elevated advanced oxidation protein products (AOPP) and malondialdehyde (MDA) concentrations have been consistently reported in patients with SCA, both at a systemic or RBC level [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. As a consequence, it would be expected that RBC and plasma from patients with SCA exhibit decreased antioxidant capacities.…”

Section: Introductionmentioning

confidence: 99%

“…However, rather inconsistent results were reported in the literature. For instance, Biswal et al [ 11 ] reported lower superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities in SCA children compared to controls. Mockesch et al [ 7 ] found higher SOD activity in SCA than in healthy children and similar CAT and GPX activities in the two populations.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Oxidative Stress Biomarkers and Genetic Polymorphisms on the Clinical Severity of Hydroxyurea-Free Senegalese Children with Sickle Cell Anemia

et al. 2020

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Oxidative stress would play a role in the pathophysiology of sickle cell anemia (SCA). We tested the impact of common SCA genetic modifiers (alpha-thalassemia, G6PD deficiency, HbF quantitative trait loci; QTL) and pro/antioxidant genes polymorphisms (SOD2 rs4880, XO rs207454, MPO rs233322) on oxidative stress biomarkers (AOPP, MDA, MPO, XO, MnSOD, CAT, GPx) and clinical severity in 301 Senegalese SCA hydroxyurea-free children at steady-state (median age 9.1 years, sex ratio H/F = 1.3). Plasma oxidative stress biomarkers were compared with those of a control group (AA). CAT activity, AOPP, and MDA levels were higher in SCA than in AA individuals while XO, GPX, and MnSOD activities were lower. The presence of alpha-thalassemia decreased MDA level and MPO activity but no effect of the HbF QTL or G6PD deficiency was observed. SCA children who experienced their first hospitalized complication before 3 years old had higher MnSOD and CAT activities than the other children while those with no hospitalized VOC in the previous 2 years presented higher GPX activity. Age of the first hospitalized complication and AOPP levels were affected by the MPO rs2333227 SNP. Our results suggest that alpha-thalassemia modulates oxidative stress in SCA, presumably because of a reduction in the MPO activity.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of Oxidative Stress Biomarkers and Genetic Polymorphisms on the Clinical Severity of Hydroxyurea-Free Senegalese Children with Sickle Cell Anemia

et al. 2020

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“…Nevertheless, we found no significant correlation between CRP and fetal hemoglobin ( Table 2). On the other hand, there is strong relation concerning oxidative stress and inflammation and both are linked to SCD pathogenesis [5,32,[37][38][39]. Earlier we documented GA exhibited strong anti-oxidant properties among SCA patients [22].…”

Section: Discussionmentioning

confidence: 85%

Effect of Gum Arabic (Acacia senegal) on C-reactive protein level among sickle cell anemia patients

Kaddam

2020

BMC Res Notes

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Objectives: Inflammation is ongoing process among sickle cell anemia even during steady state. C reactive protein (CRP) is cardinal marker that utilized widely as inflammatory indicator. Gum Arabic (GA) is gummy exudates from Acacia senegal tree. Fermentation by colonic bacteria increases serum butyrate concentrations, so considered as prebiotic agent. Gum Arabic (GA) has anti-inflammatory activity through butyrate. Earlier we proved that regular intake of GA increased fetal hemoglobin and anti-oxidant capacity most likely through raised level of butyrate, which would ameliorate symptoms of sickle cell anemia. Best of our knowledge this is the first study conducted to investigate GA intake on inflammatory markers among sickle patients. Results: This was a retrospective study conducted on stored samples from trial of Gum Arabic and sickle cell anemia. Quantitative CRP was measured by Mindray BS 200 before and after Gum Arabic consumption for 12 weeks. Daily intake of GA significantly decreased C reactive protein level (P.V = 001) (95% CI 0.943-3.098). No correlation between CRP and age, fetal hemoglobin, hemolysis markers and white blood cells. Our findings revealed novel effect of GA as anti-inflammatory agent could be consumed as natural dietary supplement to modulate disease severity and downregulate inflammatory process.

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“…RBCs are permanently in danger of oxidative stress across their lifetime due to the high cellular concentration of oxygen and Hb [ 49 , 50 ]. It also leads to a series of changes, such as crosslinking of membrane protein, reduction of deformability, and release of MetHb, which further aggravates the free radical burst and causing secondary damage to the body [ 51 – 53 ].…”

Section: Discussionmentioning

confidence: 99%

Downregulated Recycling Process but Not De Novo Synthesis of Glutathione Limits Antioxidant Capacity of Erythrocytes in Hypoxia

Wang

Zhao

Xiong

et al. 2020

Oxidative Medicine and Cellular Longevity

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Red blood cells (RBCs) are susceptible to sustained free radical damage during circulation, while the changes of antioxidant capacity and regulatory mechanism of RBCs under different oxygen gradients remain unclear. Here, we investigated the changes of oxidative damage and antioxidant capacity of RBCs in different oxygen gradients and identified the underlying mechanisms using an in vitro model of the hypoxanthine/xanthine oxidase (HX/XO) system. In the present study, we reported that the hypoxic RBCs showed much higher oxidative stress injury and lower antioxidant capacity compared with normoxic RBCs. In addition, we found that the disturbance of the recycling process, but not de novo synthesis of glutathione (GSH), accounted for the significantly decreased antioxidant capacity of hypoxic RBCs compared to normoxic RBCs. We further elucidated the underlying molecular mechanism by which oxidative phosphorylation of Band 3 blocked the hexose monophosphate pathway (HMP) and decreased NADPH production aggravating the dysfunction of GSH synthesis in hypoxic RBCs under oxidative conditions.

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Oxidative stress, antioxidant capacity, biomolecule damage, and inflammation symptoms of sickle cell disease in children

Abstract: SCD children have high oxidative stress, and conversely, decreased antioxidant activity. Decrease in antioxidant activity might explained the reduction in lipid peroxidation, protein carbonylation and increased inflammation, which in turn intensify the symptoms of SCD in children.

Cited by 44 publications

References 38 publications

Influence of Oxidative Stress Biomarkers and Genetic Polymorphisms on the Clinical Severity of Hydroxyurea-Free Senegalese Children with Sickle Cell Anemia

Influence of Oxidative Stress Biomarkers and Genetic Polymorphisms on the Clinical Severity of Hydroxyurea-Free Senegalese Children with Sickle Cell Anemia

Effect of Gum Arabic (Acacia senegal) on C-reactive protein level among sickle cell anemia patients

Downregulated Recycling Process but Not De Novo Synthesis of Glutathione Limits Antioxidant Capacity of Erythrocytes in Hypoxia

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