Oxidative Stress and Varicocele Pathophysiology

Standardized Laboratory Procedures, Quality Control and Quality Assurance Are Key Requirements for Accurate Semen Analysis in the Evaluation of Infertile Male

“…Varicocele is the most common correctable cause of infertility prevalent in up to 80% of men with secondary infertility [ 40 ]. This clinical diagnosis can impair spermatogenesis through testicular hyperthermia, ischemia, increased oxidative stress, and reflux of adrenal metabolites [ 41 ]. Varicocelectomy has been found to significantly improve semen parameters in 60% to 80% of cases resulting in spontaneous pregnancy in up to 60% of cases [ 42 ].…”

Infertility prognostic factors of the pro-/antioxidant system in patients with varicocele

“…Òîìó ä³à´íîñòèêà òà àíàë³ç áàëàíñó àê-òèâíîñò³ ïðî-òà àíòèîêñèäàíòíèõ åíçèì³â äîçâîëÿº ïðî´íîçóâàòè ôåðòèëüí³ñòü íå ò³ëüêè ïðè ïàòîëî´³÷íèõ çì³íàõ â åÿêóëÿò³, àëå ³ â óìîâàõ íîðìîñïåð쳿 [1]. Âðàõîâóþ÷è ïðî´ðåñèâíå ïîã³ðøåííÿ ôóíêö³¿ ÿº÷îê ïðè âàðèêîöåëå, âàaeëèâèì º ïîøóê ðàíí³õ òà åôåêòèâíèõ ä³à´íîñòè÷íèõ êðèòåð³¿â, ÿê³ á äîïîìîãëè çáåðåãòè ôåðòèëüí³ñòü [2,5,6,9].…”

“…Íà äàíèé ÷àñ ï³äòâåðäaeåíî, ùî õâîðèì íà âàðèêîöåëå ïðèòàìàííèé îêñèäàòèâíèé ñòðåñ [2,6], ï³äâèùåíà ïðîäóêö³ÿ ÀÔÊ, äåô³öèò àíòèîêñèäàíòíî¿ ñèñòåìè ó ñïåðìà-òîçî¿äàõ [2,6,13]. "Çîëîòèì ñòàíäàðòîì" âè-çíà÷åííÿ îêñèäàòèâíîãî ñòðåñó ïðè âàðèêîöåëå çàðåêîìåíäóâàâ ñåáå ìàëîíîâèé ä³àëü-äåã³ä (ÌDÀ) [9,13].…”