Oxidative stress and toxicity of gold nanoparticles in Mytilus edulis

Tedesco, Sara; Doyle, Hugh; Blasco, Julián; Redmond, Gareth; Sheehan, David

doi:10.1016/j.aquatox.2010.03.001

Cited by 271 publications

(155 citation statements)

References 57 publications

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“…In Nereis diversicolor, Mytilus galloprovincialis, Porcellio scaber (Isopoda, Crustacea), Mytilus edulis and zebrafish, nanoparticles of silver, CuO, TiO 2 , and nickel accumulated in the digestive glands after dietary exposure, where they induced oxidative stress and destabilized digestive gland cell membranes. [233][234][235][236][237][238][239] Silver nanoparticles were also internalized into the animal's gut epithelium 236 and caused damage to its digestive functions. 237 In summary, after entering the digestive system, nanoparticles primarily interact with the stomach and intestines.…”

Section: Digestive Nanotoxicitymentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

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Section: Digestive Nanotoxicitymentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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“…In vivo studies on cytotoxicity of AuNPs In a recent study, blue mussel Mytilus edulis was observed to experience oxidative stress within 24 h of exposure to AuNPs [26] , indicating the possible impact of AuNPs to the ecosystem and aquatic animals. The same investigators also proposed the use of M edulis as an ideal animal model for environmental toxicology studies of NPs.…”

Section: Aunps and Cytotoxicitymentioning

confidence: 99%

Gold nanoparticles in cancer therapy

et al. 2011

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The rapid advancement of nanotechnology in recent years has fuelled a burgeoning interest in the field of nanoparticle research, in particular, its application in the medical arena. A constantly expanding knowledge based on a better understanding of the properties of gold nanoparticles (AuNPs) coupled with relentless experimentation means that the frontiers of nanotechnology are constantly being challenged. At present, there seems to be heightened interest in the application of AuNPs to the management of cancer, encompassing diagnosis, monitoring and treatment of the disease. These efforts are undertaken in the hope of revolutionizing current methods of treatment and treatment strategies for a multifactorial disease such as cancer. This review will focus on the current applications of AuNPs in cancer management.

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“…The reduction of metal ions by combinations of biomolecules found in these extracts such as enzymes or proteins, amino acids, polysaccharides, and vitamins [18] is environmentally benign, yet chemically complex. Gold nanoparticles (AuNPs) are widely used in biotechnology and biomedical field because of their large surface area, and high electron conductivity [19]. The modification of the nanometers is conducted to enhance the interaction of these NPs with biological cells [20].…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Metal Nanoparticles Synthesized From Hibiscus Rosa Sinesis and Their Antibacterial Activity Estimation Against Nine Pathogenic Bacteria

Tyagi

Kumar

Tyagi

2017

Asian J Pharm Clin Res

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Objective: This study demonstrates a simple, cost-effective protocol for biosynthesis of stable silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) from Hibiscus rosa-sinesis and their comparison by applying antibacterial activities against nine pathogenic bacterial species.Methods: AgNPs and AuNPs were biosynthesized from H. rosa-sinesis. The antibacterial activities of biosynthesized AgNPs (bio-AgNPs) and biosynthesized AuNPs (bio-AuNPs) were evaluated against 9 pathogenic bacterial species Pseudomonas aeruginosa, Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Enterobacter aerogenes, Escherichia coli, Streptococcus pneumoniae, Aeromonas hydrophila by the agar disc diffusion method.Results: Biological synthesized AgNP/AuNPs were characterized by an ultraviolet-visible (UV-Vis) spectrophotometer, Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). The existence of silver and gold ions in the extracts was conformed (primary confirmation) through UV-Vis and the maximum plasmon peak was observed at 402 and 530 nm of bio-AgNPs and bio-AuNPs, respectively. Bio-AgNPs were obtained in 13.01-28.14 nm size range, whereas bio-AuNPs were in 6.32-18.19 nm size range after analysis of TEM images. The results of FTIR spectra indicate that the bio-AuNPs were bound to amine groups and bio-AgNPs to carboxylate ion groups. The antibacterial activities of AgNP/AuNP, the zone of inhibition significantly increased with the increases of concentrations of bio-AgNPs in all pathogenic bacterial species except in the case of S. epidermidis at 50%, Streptococcus aerogenes and A. hydrophila at 70%, whereas in the case of bio-AuNPs antibacterial activities were displayed only against B. subtilis at 20% and 100% concentration. Conclusion:This study suggests that AgNPs exhibits outstanding antibacterial activity against pathogenic bacteria as compared to AuNPs synthesized from H. rosa-sinensis leaf extract and insights to their potential applicability as an alternative antibacterial agent in microbial and human health system to reduce the resistance ability of pathogenic bacteria.

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Oxidative stress and toxicity of gold nanoparticles in Mytilus edulis

Cited by 271 publications

References 57 publications

Perturbation of physiological systems by nanoparticles

Perturbation of physiological systems by nanoparticles

Gold nanoparticles in cancer therapy

Comparative Analysis of Metal Nanoparticles Synthesized From Hibiscus Rosa Sinesis and Their Antibacterial Activity Estimation Against Nine Pathogenic Bacteria

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