Oxidative Stress and Thyroid Disorders

Periyasamy, Loganayaki; Babu, Kokelavani Nampalli; Krishnamoorthy, Sneha; Behlen, Jonathan; Muthusami, Sridhar; Stanley, Jone A.

doi:10.1007/978-981-15-9411-3_1

Cited by 1 publication

(3 citation statements)

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“…Oxidative stress causes chemical modification and damage to macromolecules in the body such as protein, carbohydrates, lipids, and DNA that leads to acute or chronic diseases of the nervous, respiratory, cardiovascular, and immune systems and induces ageing and cancer as well Studies found that the biomarkers of oxidative stress have elevated levels in thyroid disorders such as hypothyroidism, hyperthyroidism, goitre, thyroiditis, autoimmune thyroid diseases, and thyroid cancer through the activation of many signalling mechanisms. Patients with different types of thyroid cancer have suppressed levels of antioxidants [30,31].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…In healthy conditions, the thyroid gland uses ROS in the biosynthesis of T3 and T4, and the thyroid cells are well adapted to endogenously produced ROS in basal and goitre conditions as long as antioxidant defence systems such as superoxidase dismutase (SOD), glutathione peroxidase (GPx), vitamin C, and E can regulate the production and scavenging of ROS [30]. However, lacking in cellular homeostasis of ROS due to a deficiency of antioxidants can disturb thyroid functions and lead to carcinogenesis [27,30,31]. Consequently, measuring the activity of antioxidants lets us evaluate the conditions of the antioxidant defence system, as suppressed levels may be a sign of insufficient defence against free radicals and would be helpful in the prognosis of some diseases.…”

Section: Discussionmentioning

confidence: 99%

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Possibility of measuring serum taurine level as an early marker in the prognosis of thyroid disorders, especially thyroid cancer

Magdoline M. I. Mousa,

Ibraheem M. A. EL Agouza,

Ayman A. Amin

et al. 2024

GSC Biol. Pharm. Sci.

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People's awareness of thyroid diseases has gradually grown along with the gradual rise in thyroid cancer incidence. Thyroid dysfunction imposes a significant psychological burden on those who are diagnosed, as it affects most physiological processes. At the moment, ultrasonography and fine needle aspiration cytology are the primary methods used to diagnose thyroid cancer. There are still certain thyroid nodules that cannot be accurately and adequately classified as benign or malignant prior to surgery. Consequentially, we suggested using a more sensitive biomarker to diagnose thyroid cancer. Taurine is measured in the plasma of 60 patients from the National Cancer Institute and 10 healthy volunteers. After a full clinical examination, 20 patients were diagnosed with goitres, 20 with benign tumours, and 20 with malignant tumours. The results showed non-significant (P > 0.05) changes in the levels of TSH in all patients except in the goitre group (P < 0.001). Serum taurine levels exhibited values that significantly differed from normal (P< 0.05) for goitre and benign tumours and (P < 0.001) for malignant tumours. In conclusion, it would appear that taurine can be used as a sensitive biomarker in the early prognosis of thyroid cancer.

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Section: Discussionmentioning

confidence: 99%