Oxidative stress and the unfulfilled promises of antioxidant agents

Giorgio, Marco

doi:10.3332/ecancer.2015.556

Cited by 22 publications

(25 citation statements)

References 78 publications

(68 reference statements)

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“…The controversy relies not only on the apparent paradox between antioxidant and pro-oxidant properties of the molecule but also on the physiological role of oxidative stress (54).…”

Section: Discussionmentioning

confidence: 99%

Hyperuricemia, Cardiovascular Profile, and Comorbidity in Older Men and Women: The Pro.V.A. Study

Musacchio

Perissinotto

Sartori

et al. 2017

Rejuvenation Research

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Hyperuricemia (HU) is growing worldwide and associates with several medical conditions in the elderly. However, data about older people and possible gender differences are sparse. The aim of this study was to compare HU prevalence rates and association with relevant medical disorders in elderly subjects of both sexes. Pro.V.A. is a survey of 3099 individuals aged 65+, focusing on chronic diseases and disability. Uric acid (UA) levels were dichotomized using 6.0 mg/dL (females) and 7.0 mg/dL (males), and multivariate logistic regression models were used to estimate odds ratios (ORs) between HU and single comorbidity. HU prevalence was 21.5% in females and 15.8% in males. HU was associated with most anthropometric and laboratory variables in women, but not in men. After adjustment for age, body mass index, and renal function, HU was independently associated with the presence of cardiovascular diseases in both sexes. In women, HU was associated with hand osteoarthritis (OR = 1.52; 95%CI: 1.12-2.08) and edentulism (OR = 1.31; 95%CI: 1.01-1.71), while resulted protective for osteoporosis (OR = 0.69; 95%CI: 0.53-0.91). In men, HU was significantly related with knee osteoarthritis (OR = 1.72; 95%CI: 1.06-2.79) and chronic obstructive pulmonary disease (OR = 1.60; 95%CI: 1.04-2.45). The presence of ≥4 comorbidities was a stronger determinant of HU in men (OR = 2.54; 95%CI: 1.21-5.37) than in women (ns). Patterns of age-dependent UA increase are markedly different in men and women. HU prevalence is substantial and its association with other diseases is gender specific, connoting a peculiar clinical profile.

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“…The controversy relies not only on the apparent paradox between antioxidant and pro-oxidant properties of the molecule but also on the physiological role of oxidative stress (54).…”

Section: Discussionmentioning

confidence: 99%

Hyperuricemia, Cardiovascular Profile, and Comorbidity in Older Men and Women: The Pro.V.A. Study

Musacchio

Perissinotto

Sartori

et al. 2017

Rejuvenation Research

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“…In humans, a diet based on antioxidant-rich foods results in an increase in serum antioxidant capacity and a decrease in oxidative stress [22,23,24], and protects from cancer and heart disease [25]. Administration of antioxidants as dietary supplements does not seem to have the same beneficial effect [26].…”

Section: Introductionmentioning

confidence: 99%

Antioxidants and Cardiovascular Risk Factors

Pellegrino

2016

Diseases

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Cardiovascular disease (CVD), the world’s primary cause of death and disability, represents a global health problem and involves a great public financial commitment in terms of both inability to work and pharmaceutical costs. CVD is characterized by a cluster of disorders, associated with complex interactions between multiple risk factors. The early identification of high cardiovascular risk subjects is one of the main targets of primary prevention in order to reduce the adverse impact of modifiable factors, from lifestyle changes to pharmacological treatments. The cardioprotective effect of food antioxidants is well known. Indeed, a diet rich in fruits and vegetables results in an increase in serum antioxidant capacity and a decrease in oxidative stress. In contrast, studies on antioxidant supplementation, even those that are numerically significant, have revealed no clear benefit in prevention and therapy of CVD. Both short- and long-term clinical trials have failed to consistently support cardioprotective effects of supplemental antioxidant intake. The aim of this review is to evaluate the antioxidant effects on the main cardiovascular risk factors including hypertension, dyslipidemia, diabetes.

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“…Furthermore, the anti-oxidative capacity of Fl has been discussed [4]. In general, antioxidants are regarded to be far from scientifically founded clinical application [29]. It largely remains unclear whether, when, and how much antioxidants should be taken [29][30][31], the more so as some antioxidants may act as pro-oxidants [32].…”

Section: If Vasoconstriction Is Indeed Favorable In Venousmentioning

confidence: 99%

“…In general, antioxidants are regarded to be far from scientifically founded clinical application [29]. It largely remains unclear whether, when, and how much antioxidants should be taken [29][30][31], the more so as some antioxidants may act as pro-oxidants [32]. In any case, it is unclear why antioxidants should be used in conditions associated with tissue hypoxia, such as CVI.…”

Section: If Vasoconstriction Is Indeed Favorable In Venousmentioning

confidence: 99%

The potential use of flavonoids as venoactive drugs and the role of citrus fruits

Jargin¹

2018

J Intercult Ethnopharmacol

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Oxidative stress and the unfulfilled promises of antioxidant agents

Cited by 22 publications

References 78 publications

Hyperuricemia, Cardiovascular Profile, and Comorbidity in Older Men and Women: The Pro.V.A. Study

Hyperuricemia, Cardiovascular Profile, and Comorbidity in Older Men and Women: The Pro.V.A. Study

Antioxidants and Cardiovascular Risk Factors

The potential use of flavonoids as venoactive drugs and the role of citrus fruits

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