Oxidative stress and Parkinson’s disease: conflict of oxidant-antioxidant systems

Hemmati-Dinarvand, Mohsen; Saedi, Samira; Valilo, Mohammad; Kalantary‐Charvadeh, Ashkan; Sani, Mahmood Alizadeh; Kargar, Roya; Safari, Hossein; Samadi, Nasser

doi:10.1016/j.neulet.2019.134296

Cited by 96 publications

(68 citation statements)

References 77 publications

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“…Oxidative stress is a key factor in Parkinson's disease. Reactive oxygen species cause serious damage and death of dopamine-producing cells when the antioxidant capacity of the cell is reduced against oxidative stress [22,23]. For this reason, compounds may be very effective in treating PD based on in vitro and in vivo models if they demonstrated free radical scavenger effects in cell-free assays or anti-ROS influences in cell-based tests [24].…”

Section: Biological Activities Of the Isolated Compoundsmentioning

confidence: 99%

Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus

et al. 2019

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Seven known echinulin-related indolediketopiperazine alkaloids (1–7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson’s disease. (−)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson’s disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model.

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Section: Biological Activities Of the Isolated Compoundsmentioning

confidence: 99%

Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus

et al. 2019

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“…Indeed, cellular in lammation and stress are known to cause reactive astrogliosis, which in turn leads to the generation of astrocytic ROS [147]. In this context, ROS are regarded as important modulators of PD [148,149]. At the same time, dopaminergic neurons of the substantia nigra are especially susceptible to processes of degeneration in PD [141,150].…”

Section: Parkinson's Disease and Oxidative Stressmentioning

confidence: 99%

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

Madireddy¹,

Madireddy²

2019

J Neurosci Neurol Disord

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Vitamin E Antioxidant, Neuroprotection Vitamin E is a scavenger of several ROS and serves to reduce their reactivity and toxicity. It offers protection from the propagative damage of ROS by inhibiting the oxidative modifi cation of lipoproteins AD [74-79,82-86] PD [175-177,79] ALS [193,217,218] Vitamin C Antioxidant, Neuroprotection Vitamin C is an excellent antioxidant, suitable in reducing ROS levels, lipid peroxidation, and oxidative stress. It is also useful in regenerating other antioxidants. AD [81,82,75,77,79] PD [166-168] ALS [213,214] Vitamin D Antioxidant Neuroprotection Vitamin D prevent oxidative stress, lower the production of free radicals, and reduce neurotoxicity through the enhancement of autophagy signaling pathways AD [74-78,30,16,80] PD [157-159,169-174] ALS [215,216] Vitamin A Antioxidan Vitamin A prevent the formation of Aβ plaques AD [16,30,74-78] Vitamin B Antioxidant Neuroprotection Vitamin B perform antioxidant and neuroprotective functions AD [88-90] PD [157-159,162-165] HD [105] Curcumin Antioxidant Anti-infl ammatory Neuroprotection Curcumin is a scavenger of free radicals and reduces mitochondrial disfunction. AD [100,101] Omega−3 fatty acids Antioxidant Anti-infl ammatory Omega-3 fatty acids reduce ROS formation acting as free radical scavengers.

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“…Given the progressive nature of the disorder, disease pathogenesis is mainly triggered by continual processes such as geometric accumulation of oxidative radicals brought about by cellular inclusions and mitochondrial dysfunction [8][9][10] . For example, PINK1 and Parkin loss of function impair mitophagy and cause accumulation of damaged mitochondria, leading to enhanced electron leakage and formation of superoxides [11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

Enhanced accumulation of reduced glutathione by Scopoletin improves survivability of dopaminergic neurons in Parkinson’s model

et al. 2020

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Parkinson’s disease (PD) is a neuromotor disorder, primarily manifested by motor anomalies due to progressive loss of dopaminergic neurons. Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis. Involvement of oxidative stress in PD is further substantiated through ROS induced Parkinsonian models and elevated oxidative markers in clinical PD samples; thereby, making modulation of neuronal oxidative load as one of the major approaches in management of PD. Here we have found a potent antioxidant moiety Scopoletin (Sp), a common derivative in most of the nootropic herbs, with robust neuroprotective ability. Sp increased cellular resistance to ROS through efficient recycling of GSH to prevent oxidative damage. The Sp treated cells showed higher loads of reduced glutathione making them resistant to perturbation of antioxidant machinery or neurotoxin MPP+. Sp could restore the redox balance, mitochondrial function, and prevented oxidative damage, leading to recovery of dopaminergic neural networks and motion abilities in Drosophila genetic model of PD. Our data also suggest that Sp, in combination increases the therapeutic potency of L-DOPA by mitigating its chronic toxicity. Together, we highlight the possible ability of Sp in preventing oxidative stress mediated loss of dopaminergic neurons and at the same time enhance the efficacy of dopamine recharging regimens.

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Oxidative stress and Parkinson’s disease: conflict of oxidant-antioxidant systems

Cited by 96 publications

References 77 publications

Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus

Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

Enhanced accumulation of reduced glutathione by Scopoletin improves survivability of dopaminergic neurons in Parkinson’s model

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