Oxidative Stress and Obesity- and Type 2 Diabetes-Induced Heart Failure

Demaison, Luc

doi:10.3390/antiox9080653

Cited by 7 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, previous studies have suggested that various pathologic conditions, such as toxins, medications, hypertension, diabetes, and obesity, might trigger cardiomyocyte autophagy and apoptosis, cause disordered cardiac structure, and then lead to cardiac dysfunction [44][45][46][47]. Therefore, our findings will provide a new perspective and novel therapeutic targets for effectively alleviating myocardial injury.…”

Section: 4mentioning

confidence: 59%

miR-488-3p Protects Cardiomyocytes against Doxorubicin-Induced Cardiotoxicity by Inhibiting CyclinG1

Yan

Cao

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Objective. To investigate the protective effects and regulatory mechanism of miR-488-3p on doxorubicin-induced cardiotoxicity. Methods. The C57BL/6 mice and primary cardiomyocytes were used to construct doxorubicin-induced cardiomyocyte injury models in vivo and in vitro. The levels of miR-488-3p and its downstream target genes were analyzed by quantitative real-time PCR. Mouse cardiac function, cell survival, cellular injury-related proteins, and the apoptosis level of cardiomyocytes were analyzed by echocardiography, MTT analysis, Western blotting, and DNA laddering separately. Results. Cardiomyocyte injury caused by a variety of stimuli can lead to the reduction of miR-488-3p level, especially when stimulated with doxorubicin. Doxorubicin led to significant decrease in cardiac function, cell autophagic flux blockage, and apoptosis in vivo and in vitro. The expression of miR-488-3p’s target gene, CyclinG1, increased remarkably in the doxorubicin-treated neonatal mouse cardiomyocytes. Overexpression of miR-488-3p inhibited CyclinG1 expression, increased cardiomyocyte viability, and attenuated doxorubicin-induced cardiomyocyte autophagic flux blockage and apoptosis. Conclusions. miR-488-3p is one of the important protective miRNAs in doxorubicin-induced cardiotoxicity by inhibiting the expression of CyclinG1, which provides insight into the possible clinical application of miR-488-3p/CyclinG1 as therapeutic targets in doxorubicin-induced cardiovascular diseases.

show abstract

Section: 4mentioning

confidence: 59%

miR-488-3p Protects Cardiomyocytes against Doxorubicin-Induced Cardiotoxicity by Inhibiting CyclinG1

Yan

Cao

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Catalase (CAT) is a key enzyme that decomposes hydrogen peroxide into water and oxygen, serving as a major component of the cellular antioxidant defense system [ 46 ]. Oxidative stress leads to an increase in hydrogen peroxide levels.…”

Section: Resultsmentioning

confidence: 99%

“…In chronic heart failure, myocardial injury, ventricular remodeling, and alterations in mitochondrial structure and number occur, leading to a shift in myocardial metabolism from fatty acids to glucose, decreased glucose oxidation, and increased glycolysis [ 46 ]. TG hydrolysis, one of the pathways for free fatty acid production, decreases after heart failure, leading to increased serum levels [ 46 ]. The study suggests that crocetin can regulate lipid and energy metabolism to some extent and promote angiogenesis, increasing oxygen supply and further powering myocardial contraction.…”

Section: Discussionmentioning

confidence: 99%

Preventive and Therapeutic Effects of Crocetin in Rats with Heart Failure

Ma,

Li,

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

Gardenia is both a food and medicine plant. It is widely used for cardiovascular protection, and its main bioactive ingredient is crocetin. This study aims to observe the therapeutic effects of crocetin on chronic heart failure in rats induced by various etiologies. It further compares the efficacy differences between preventative and treatment administration, varying dosages, and treatment durations, to provide improved guidance for medication in heart failure rats and determine which categories of chronic heart failure rats might benefit most from crocetin. Chronic heart failure models induced by abdominal aorta constriction, renal hypertension, and coronary artery ligation were constructed. By examining cardiac function, blood biochemistry, and histopathology, the study assessed the preventive and therapeutic effects of crocetin on load-induced and myocardial ischemia-induced heart failure. The results showed that in all three models, both treatment and preventative administration of crocetin significantly improved chronic heart failure in rats, especially in preventative administration. The results indicate crocetin may be beneficial for improving symptoms and functional capacity in rats with heart failure. Furthermore, long-term administration was more effective than short-term administration across all three rat models, with therapeutic onset observed over 6 weeks.

show abstract

“…The redox imbalance can be consequential on various diseases, like metabolic syndrome, obesity, diabetes, cancer, etc (38,39). The potency of exogenous antioxidants is assessed biochemically by measuring the reducing power and percentage inhibition of oxidative stressors (i.e., free radicals).…”

Section: Discussionmentioning

confidence: 99%

Effects of hydroethanolic garlic extract on oxidative stress, lipolysis, and glycogenesis in high-fat diet-fed Drosophila melanogaster

Adepoju,

Ntwasa,

Lebelo

et al. 2024

J Herbmed Pharmacol

View full text Add to dashboard Cite

Introduction: Metabolic syndrome is multifaceted health condition associated with metabolism, which leads to the accumulation of oxidation products and impairment of the antioxidant system. Medicinal, edible plant alternatives are being sought to prevent the predisposing factors of metabolic syndrome, one of which is obesity. We studied the effects of hydroethanolic garlic extract (HGE) on oxidative stress, lipolysis, and glycogenesis in high-fat diet-fed Drosophila melanogaster. Methods: The HGE was processed and antioxidant assays (in vitro and in vivo) coupled with metabolic biomarkers were assayed following standard procedures. Results: HGE inhibited ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), hydroxyl, and hydrogen peroxide radicals in high-fat-fed D. melanogaster. The HGE also reduced the activity of superoxide dismutase and increased catalase activity significantly. The HGE promoted lipolysis and glycogenesis by reducing cholesterol, triglycerides, and total sugar concentrations while glycogen content was increased. Conclusion: Our results revealed that HGE improved the antioxidant defense system and promoted lipolysis and glycogenesis in metabolic deranged D. melanogaster. This suggests the therapeutic usefulness of garlic in the management of metabolic diseases.

show abstract

Oxidative Stress and Obesity- and Type 2 Diabetes-Induced Heart Failure

Abstract: Obesity is a risk factor for the development of type 2 diabetes (T2D), which is associated with cardiovascular diseases [...]

Cited by 7 publications

References 15 publications

miR-488-3p Protects Cardiomyocytes against Doxorubicin-Induced Cardiotoxicity by Inhibiting CyclinG1

miR-488-3p Protects Cardiomyocytes against Doxorubicin-Induced Cardiotoxicity by Inhibiting CyclinG1

Preventive and Therapeutic Effects of Crocetin in Rats with Heart Failure

Effects of hydroethanolic garlic extract on oxidative stress, lipolysis, and glycogenesis in high-fat diet-fed Drosophila melanogaster

Contact Info

Product

Resources

About