Oxidative stress and mitochondrial damage in lambda-cyhalothrin toxicity: A comprehensive review of antioxidant mechanisms

Xu, Xiaoqing; Yu, Yixin; Ling, Min; Ares, Irma; Martínez, Marta; Lopez-Torres, Bernardo; Maximiliano, Jorge-Enrique; Martínez-Larrañaga, María-Rosa; Wang, Xu; Anadón, Arturo; Martínez, María-Aránzazu

doi:10.1016/j.envpol.2023.122694

Cited by 13 publications

(1 citation statement)

References 133 publications

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“…The disagreement between these observations may be due to the diversity among these study populations. Although many in vivo and in vitro toxicological studies have shown that exposure to pyrethroids results in increased ROS and oxidative stress, most of these findings are based on exposure doses and/or concentrations that far exceed realistic environmental exposure levels. , More investigations are therefore needed to explore whether environmental exposure to pyrethroids increases oxidative stress in general populations.…”

Section: Resultsmentioning

confidence: 99%

First Evidence of the Associations of Exposure to Pyrethroid Insecticides with the Risk of Gestational Diabetes Mellitus

Ma,

Song,

et al. 2024

Environ. Sci. Technol. Lett.

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Pyrethroids, a class of extensively used insecticides, may pose health risks to humans. Whether pyrethroid exposure contributes to the development of gestational diabetes mellitus (GDM) in pregnant women remains unknown. The potential association of urinary concentrations of pyrethroid metabolites [3-phenoxybenzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzoic acid] with the risk of GDM was assessed using a nested case-control study of 220 GDM cases and 440 controls from a prospective cohort. The mediation roles of oxidative stress biomarkers [advanced glycation end products (AGEs) and malondialdehyde (MDA)] in the associations were investigated. Urinary concentrations of 3-PBA in these cases were significantly higher than those of the controls. Urinary 3-PBA was positively associated with the risk of GDM. The adjusted odds of GDM significantly increased by 32% in each unit increment of the ln-transformed concentration of urinary 3-PBA. The significant dose−response relationships of GDM with serum AGEs (P trend = 0.03) and MDA (P trend < 0.001) were observed. However, there were no significant correlations between 3-PBA and AGEs or MDA, nor was there a significant mediation effect of AGEs or MDA on the association of 3-PBA with GDM. We provide the first evidence that early gestational exposure to pyrethroids is an environmental risk factor for GDM.

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Section: Resultsmentioning

confidence: 99%

First Evidence of the Associations of Exposure to Pyrethroid Insecticides with the Risk of Gestational Diabetes Mellitus

Ma,

Song,

et al. 2024

Environ. Sci. Technol. Lett.

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Biomarkers at the Individual and Biochemical Level: Effects of Pure and Formulated Lambda‐Cyhalothrin in Boana pulchella Tadpoles (Duméril and Bibron, 1841)

Barreto,

Villanova,

Parra

et al. 2024

Enviro Toxic and Chemistry

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We compared the effects of lambda‐cyhalothrin as the pure active ingredient and as a formulated product (Zero®), on the larval stage of the autochthonous species Boana pulchella. We evaluated ecotoxicological endpoints, behavioral and developmental alterations, and the biochemical detoxifying, neurotoxic, and oxidative stress responses, covering a wide concentration range from environmental to high application levels. Both pyrethroid preparations displayed similar ecotoxicity (median lethal concentration of ~0.5 mg/L), with the lethal effect of Zero® being more pronounced than that of the active ingredient. Sublethal behavioral alterations in natatory activity were observed at 1000 times lower concentrations, indicating the ecological hazard of tadpole exposure to this pyrethroid at environmentally relevant concentrations. Biochemical endpoints in B. pulchella larvae showed significant responses to lambda‐cyhalothrin in the ng/L range; these responses were different for the pure or the formulated product, and they were variable at higher concentrations. Principal components analysis confirmed the prevalence of biochemical responses as early endpoints at the lowest lambda‐cyhalothrin concentrations; the Integrated Biomarker Response Index proportionally increased with pyrethroid concentration in a similar way for the pure and the formulated products. We conclude that lambda‐cyhalothrin is of concern from an environmental perspective, with particular emphasis on autochthonous anuran development. The battery of biochemical biomarkers included in our study showed a consistent integrated biomarker response, indicating that this is a potent tool for monitoring impacts on amphibians. Environ Toxicol Chem 2024;00:1–11. © 2024 SETAC

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UV–visible-near-IR characterization of MoO3 catalyzed photodegradation of lambda-cyhalothrin pesticide

Osumba,

Adongo,

Omolo

2024

Chem. Pap.

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Oxidative stress and mitochondrial damage in lambda-cyhalothrin toxicity: A comprehensive review of antioxidant mechanisms

Cited by 13 publications

References 133 publications

First Evidence of the Associations of Exposure to Pyrethroid Insecticides with the Risk of Gestational Diabetes Mellitus

First Evidence of the Associations of Exposure to Pyrethroid Insecticides with the Risk of Gestational Diabetes Mellitus

Biomarkers at the Individual and Biochemical Level: Effects of Pure and Formulated Lambda‐Cyhalothrin in Boana pulchella Tadpoles (Duméril and Bibron, 1841)

UV–visible-near-IR characterization of MoO3 catalyzed photodegradation of lambda-cyhalothrin pesticide

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