Oxidative stress and metal carcinogenesis

Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells

“…Excessive generation of ROS could interfere with cellular signalling pathways (Simon et al, 2000;Trachootham et al, 2009) and is one of the contributing factors in the malignant transformation of normal cells via inducing oxidative DNA damage (Klaunig et al, 2010;Lee et al, 2012). However, induction of ROS plays a significant role in the chemotherapeutic activity of several anticancer drugs and anticancer compounds (Fruehauf and Meyskens, 2007;Trachootham et al, 2009).…”

Souffrance au travail et enjeux de santé : le rôle charnière de l’inflammation et du stress oxydant

“…Du côté des molécules organiques, un système enzymatique occupe une place particulière, ce sont les mono-oxygénases à cytochromes P450 qui assurent la première phase du métabolisme des substances étrangères. Or, non seulement elles sont susceptibles de transformer ces dernières en métabolites réactifs à fort pouvoir oxydant, mais leur activité même produit des espèces (Valko, 2005 ;Jomova, 2011 ;Lee, 2012).…”

Health Effects of Metals in Particulate Matter

“…The health effects and toxicity/carcinogenicity of Cr inhalation are primarily related to its oxidation state at the time of exposure [50]. According to epidemiological studies, the hexavalent [Cr(VI) form of this metal, appears to be drastically toxic and carcinogenic, thus it has been classified as carcinogenic to humans by the IARC [51].…”

“…According to epidemiological studies, the hexavalent [Cr(VI) form of this metal, appears to be drastically toxic and carcinogenic, thus it has been classified as carcinogenic to humans by the IARC [51]. The carcinogenicity of the metal is site specific, mainly to the lungs and nasal cavity [50]. The molecular mechanisms of [Cr(VI)-induced carcinogenesis are well studied and characterized, and the main mechanism of chromium carcinogenesis, is the production of free radicals, resulting in the generation of oxidative stress, This stress causes a series of modifications that are directly linked to the establishment of the cancer phenotype.…”

“…In general, Mn and its inorganic compounds are considered to possess low mutagenic or carcinogenic potential compared with other heavy metals. The experimental evidence on its carcinogenicity does not provide any clear evidence, while the available occupational and environmental epidemiological evidence is equivocal as to whether exposure to inorganic Mn is associated with a significant cancer risk or not [50]. Apparently from in vitro data, Mn and some inorganic Mn compounds are cytocytotoxic at differing concentrations depending on the test system, generating ROS in vitro and in vivo, interfering with DNA polymerases, mitochondrial function and activating some cytokines and MAPK cell signaling cascades.…”