Oxidative stress and lipid‐derived inflammatory mediators during acute exacerbations of cystic fibrosis

Reid, David W.; Misso, N.L.A.; Aggarwal, Shashi; Thompson, Philip J.; Walters, E. Haydn

doi:10.1111/j.1440-1843.2006.00962.x

Cited by 54 publications

(38 citation statements)

References 32 publications

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“…2). Cyanide may also inhibit the activity of neutrophil catalase, which normally scavenges H 2 O 2 to limit its toxicity, thus allowing oxidative stress to continue unabated, which is a characteristic of CF lung disease [61][62][63]. The results of studies of cyanide effects on neutrophil phagocytosis are also somewhat conflicting, although the majority suggest that there is no significant inhibition [54,64].…”

Section: Potential Effects Of Cyanide On Neutrophil Function In Cfmentioning

confidence: 97%

Biosignificance of bacterial cyanogenesis in the CF lung

Anderson¹,

Roddam²,

Bettiol³

et al. 2010

Journal of Cystic Fibrosis

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Two recent studies have demonstrated the presence of biologically significant amounts of cyanide within the airways of cystic fibrosis (CF) patients infected with Pseudomonas aeruginosa. Whilst environmental strains of P. aeruginosa are known to synthesise cyanide, there has been a relative lack of investigation into bacterial cyanogenesis from a medical viewpoint, despite the role P. aeruginosa plays in many serious infection settings and especially in CF lung disease. This review discusses the implications of cyanogenesis in the CF airway in terms of bacterial ecology, host immune response, progression of lung disease and potential treatment options.

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Section: Potential Effects Of Cyanide On Neutrophil Function In Cfmentioning

confidence: 97%

Biosignificance of bacterial cyanogenesis in the CF lung

Anderson¹,

Roddam²,

Bettiol³

et al. 2010

Journal of Cystic Fibrosis

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“…For example, cysteinyl LTs have been found in the sputum and urine of patients with cystic fibrosis (CF) (Sampson et al, 1990;Spencer et al, 1992), a disease in which the inflammatory process contributes to progressive lung tissue damage, and their concentrations increase during disease exacerbations together with oxidative stress (Reid et al, 2007). Few studies have been conducted to test the hypothesis that LTRAs have the potential to ameliorate CF lung disease.…”

Section: Cyslt In Other Diseasesmentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

Bäck¹,

Dahlén²,

Drazen³

et al. 2011

Pharmacol Rev

128

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“…Cell counts were performed using standard methods (13,19,26). See the online supplement for details.…”

Section: Bal Fluid Analysismentioning

confidence: 99%

“…Chronic inflammation also appears to contribute to the progression of cystic fibrosis and chronic obstructive pulmonary disease (4)(5)(6), and neutrophilia appears to correlate with the severity of asthma (7)(8)(9). In addition, acute exacerbations in all of these lung diseases are often accompanied by an increase in neutrophilic lung inflammation or neutrophil products (10)(11)(12)(13). As such, a number of antiinflammatory therapies have been investigated to ameliorate exacerbations and slow the progression of these diseases.…”

mentioning

confidence: 99%

[¹⁸F]Fluorodeoxyglucose Positron Emission Tomography for Lung Antiinflammatory Response Evaluation

Chen¹,

Bedient²,

Kozlowski³

et al. 2009

Am J Respir Crit Care Med

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Rationale: Few noninvasive biomarkers for pulmonary inflammation are currently available that can assess the lung-specific response to antiinflammatory treatments. Positron emission tomography with [ 18 F]fluorodeoxyglucose (FDG-PET) is a promising new method that can be used to quantify pulmonary neutrophilic inflammation. Objectives: To evaluate the ability of FDG-PET to measure the pulmonary antiinflammatory effects of hydroxymethylglutarylcoenzyme A reductase inhibitors (statins) and recombinant human activated protein C (rhAPC) in a human model of experimentallyinduced lung inflammation. Methods: Eighteen healthy volunteers were randomized to receive placebo, lovastatin, or rhAPC before intrabronchial segmental endotoxin challenge. FDG-PET imaging was performed before and after endotoxin instillation. The rate of [ 18 F]FDG uptake was calculated as the influx constant K i by Patlak graphical analysis. Bronchoalveolar lavage (BAL) was performed to determine leukocyte concentrations for correlation with the PET imaging results. Measurements and Main Results: There was a statistically significant decrease in K i in the lovastatin-treated group that was not seen in the placebo-treated group, suggesting attenuation of inflammation by lovastatin treatment despite a small decrease in BAL total leukocyte and neutrophil counts that was not statistically significant. No significant decrease in K i was observed in the rhAPCtreated group, correlating with a lack of change in BAL parameters and indicating no significant antiinflammatory effect with rhAPC. Conclusions: FDG-PET imaging is a sensitive method for quantifying the lung-specific response to antiinflammatory therapies and may serve as an attractive platform for assessing the efficacy of novel antiinflammatory therapies at early phases in the drug development process. Clinical trial registered with www.clinicaltrials.gov (NCT00741013).

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Oxidative stress and lipid‐derived inflammatory mediators during acute exacerbations of cystic fibrosis

Abstract: CF exacerbations are characterized by increased oxidative stress and sputum concentrations of bioactive lipid mediators. Treatment does not modulate these aspects of inflammation and more targeted therapy needs further study.

Cited by 54 publications

References 32 publications

Biosignificance of bacterial cyanogenesis in the CF lung

Biosignificance of bacterial cyanogenesis in the CF lung

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

[¹⁸F]Fluorodeoxyglucose Positron Emission Tomography for Lung Antiinflammatory Response Evaluation

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Oxidative stress and lipid‐derived inflammatory mediators during acute exacerbations of cystic fibrosis

Abstract: CF exacerbations are characterized by increased oxidative stress and sputum concentrations of bioactive lipid mediators. Treatment does not modulate these aspects of inflammation and more targeted therapy needs further study.

Cited by 54 publications

References 32 publications

Biosignificance of bacterial cyanogenesis in the CF lung

Biosignificance of bacterial cyanogenesis in the CF lung

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

[18F]Fluorodeoxyglucose Positron Emission Tomography for Lung Antiinflammatory Response Evaluation

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[¹⁸F]Fluorodeoxyglucose Positron Emission Tomography for Lung Antiinflammatory Response Evaluation