Oxidative Stress and Inflammatory Reaction Modulation by White Wine

Abstract

Wine and olive oil, essential components of the Mediterranean diet, are considered important factors for a healthy life style. Tyrosol (T) and caffeic acid (CA) are found in both extra virgin olive oil and in white wine. Three white wines from the northeast Italy and four white wines from Germany were analyzed for their content of T and CA. These compounds were tested for their antioxidant activity and their capacity to modulate three different cytokines: IL-1 beta, IL-6, and TNF-alpha, which are currently considered to be the major cytokines influencing the acute phase of the inflammatory response. Furthermore, the antioxidant activity of T and CA was analyzed by monitoring the oxidation of a redox-sensitive probe by using laser scanning confocal microscopy. T and CA, applied at nanomolar range, were found to significantly reduce the generation of oxidants induced by azobis-amidinopropanedihydrochloride. Peripheral blood mononuclear cells (PBMC) from healthy volunteers were incubated at 37 degrees C for 12 hours with 100 ng LPS (E. coli and P. maltofilia). Increasing doses of T and CA (150 nM to 300 microM) were added and cell-associated IL-1 beta and TNF-alpha were determined by immunoreactive tests after three freeze-thaw cycles. IL-6 release was also determined in cell surnatants. LPS-stimulated PBMC showed a significant increase in cytokine release, while T and CA, used at nanomolar concentrations, were able to modulate their expression. Taken together, these results suggest a remarkable effect of white wine non-alcoholic compounds on oxidative stress and inflammatory reaction.

Wine and Grape Juice Modulate Interferon-y-induced Neopterin Production and Tryptophan Degradation in Human PBMC

“…Studies indicate that also white wine contains effective polyphenols and shows remarkable effects on oxidative stress and inflammatory reaction. E.g., tyrosol and caffeic acid, typical white wine polyphenols, are able to modulate the expression of cytokines IL-Iß, IL-6 and TNF-a which are known to influence the acute phase of the inflammatory response (23,24). Earlier, resveratrol was found to influence T-cell functional response (25).…”

Role of medicinal plants in neurodegenerative diseases

“…Resveratrol has also been proven for its anti-inflammatory effect. Studies prove that compounds such as Tyrosol and Caffeic acid of Resveratrol inhibit the effect of tumor necrosis factor a, interleukin-1b and interleukin 6 productions [16,17]. Dasgupta and Milbrandt [36] demonstrated the neuroprotective effect of Resveratrol, in which Resveratrol helps in stimulating AMP kinase and thereby affect neuronal homeostasis.…”

Phenolic Compounds from Endophytic Pseudofusicoccum sp. Isolated from Annona muricata

“…56 It has also been effective in inhibiting leukocyte 5-lipooxygenase, and protecting the Caco-2 intestinal mucosa cells against the cytostatic and cytotoxic effects produced by oxidized LDL. [57][58][59] Tyrosol was reported to have scavenging effects on reactive oxygen and nitrogen species that are implicated in human pathologies such as cardiovascular and thrombotic diseases, 55,60,61 and has been reported as a candidate to be used in stroke therapy due to its neuroprotective effect in rats. 62 It was identified as an auto-regulatory molecule with important implication on the dynamics of growth and morphogenesis in Candida albicans, a process known as quorumsensing, which is characterized by a cellular density-dependent phenomenon.…”

“…These compounds have been reported to possess diverse pharmacological activities. [56][57][58][59][60][61][62][63][64][65][67][68][69][70][71][72][73][74][75][76][77][78] Tyrosol, also known as 2-(4-Hydroxyphenyl) ethanol, is a well-known phenolic compound present in different dietary sources that can exert mild antioxidant properties based on in vitro and in vivo studies. 53 It has been produced by many fungi including Phialocephala fortinii Rac56, 36 Diaporthe eres, 54 and Glomerella cingulata.…”