Oxidative stress and inflammation response genes in miRNA-mediated mitochondrial and nuclear genome crosstalk associated with cardio-vascular diseases

Timofeeva, Sofia V.; Butenko, Elena; Romanov, Dmitry E.; Шкурат, Т. П.

doi:10.1016/j.atherosclerosis.2017.06.653

Cited by 1 publication

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“…TLR4 plays an important role in CAPE's protective effect of suppressing LPSinduced cardiac myocyte injury through TLR4/NF-κB signaling pathway (Jiang & Qu, 2017). In this paper, we also found that TLR4 MiRNAs act as regulatory factors of pathological and toxicological injury and also exert regulatory effect on oxidative stress, apoptosis, and inflammation (Timofeeva et al, 2017;Yi et al, 2013). A number of researches have demonstrated that miRNA is also related to toxic-induced injury.…”

Section: Discussionmentioning

confidence: 55%

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The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

Hao

Zhou

et al. 2023

Food Frontiers

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Cadmium (Cd) is a heavy metal toxic that can cause health problems including lung injury. This study was set out to meet the growing demand for effective treatment of lung diseases and explore the mechanism of caffeic acid phenethyl ester (CAPE, a natural phenolic acid) protect against Cd‐caused lung damage. In this study, CAPE significantly increased mice body weight, decreased lung W/D ratio, and alleviated histomorphological injury. CAPE mitigated CdCl2‐induced oxidative stress through Nrf2/HO‐1/NQO1 pathway, suppressed inflammation via MyD88/NF‐κB pathway, and alleviated apoptosis by modulating apoptosis mediators. CAPE also inhibited the CdCl2‐caused decreasing of TLR4 level and the increasing of miR‐182‐5p level, which is achieved by miR‐182‐5p sponging TLR4. Collectively, miR‐182‐5p is involved in CAPE against CdCl2‐caused lung damage by targeting TLR4. MiR‐182‐5p/TLR4 is a new pathway for inhibiting oxidative stress, apoptosis, and inflammation in CAPE‐mediated lung protection, which provides a novel avenue for treatment therapies.

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Section: Discussionmentioning

confidence: 55%

“…MiRNAs act as regulatory factors of pathological and toxicological injury and also exert regulatory effect on oxidative stress, apoptosis, and inflammation (Timofeeva et al., 2017; Yi et al., 2013). A number of researches have demonstrated that miRNA is also related to toxic‐induced injury.…”

Section: Discussionmentioning

confidence: 99%

The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

Hao

Zhou

et al. 2023

Food Frontiers

View full text Add to dashboard Cite

show abstract

Oxidative stress and inflammation response genes in miRNA-mediated mitochondrial and nuclear genome crosstalk associated with cardio-vascular diseases

Cited by 1 publication

References 0 publications

The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

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