Oxidative stress and inflammation in pregnancy

Fialová, L; Malbohán, I; Kalousová, Marta; Soukupová, J; Krofta, Ladislav; Stípek, S; Zima, Tomáš

doi:10.1080/00365510500375230

Cited by 66 publications

(37 citation statements)

References 22 publications

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“…C-reactive protein concentrations are generally higher in pregnant than in nonpregnant women, 37 and placentally derived microparticles or soluble products from the placenta are suspected of driving systemic inflammation during normal pregnancy. 23 An increased inflammatory response during pregnancy is present for preeclampsia, small-for-gestational-age infants, and preterm birth.…”

Section: Discussionmentioning

confidence: 99%

Particulate Air Pollution Exposure and C-reactive Protein During Early Pregnancy

Lee¹,

Talbott²,

Roberts³

et al. 2011

Epidemiology

102

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Background It is not well understood how air pollution leads to adverse pregnancy outcomes. One pathway may be through C-reactive protein, a biomarker of systemic inflammation that has been reported to increase the risk of preterm delivery. We examined whether air pollution influences serum concentrations of C-reactive protein in early pregnancy. Methods We studied 1696 pregnant women in Allegheny County, PA, from 1997 through 2001. C-reactive protein concentrations were assayed in blood collected before the 22nd week of gestation. We estimated levels of particles of less than 10 μm (PM10) and less than 2.5 μm diameter (PM2.5), carbon monoxide, nitrogen dioxide, sulfur dioxide, and ozone at the maternal zip code using Kriging interpolation for measurements obtained from ambient stations. Associations between air pollution and high C-reactive protein concentrations (≥8 ng/mL) were evaluated using logistic regression. Results Among nonsmokers, an observed 9.2 μg/m3 increase in PM10 (averaged over 28 days prior to the blood sample) was associated with an odds ratios of 1.41 for high C-reactive protein concentrations (95% confidence interval = 0.99–2.00). Similarly, a 4.6 μg/m3 increase in PM2.5 was associated with an odds ratio of 1.47 (1.05–2.06). The odds ratio was 1.49 (0.75–2.96) per 7.9 ppb increase in ozone during summer. There were no associations in smokers or for other air pollutants, and there was no evidence for effect-measure modification by obesity. Conclusions PM10, PM2.5, and ozone exposures were associated with increased C-reactive protein concentrations in early pregnancy, suggesting that these air pollutants contribute to inflammation and thereby possibly to adverse pregnancy outcomes.

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Section: Discussionmentioning

confidence: 99%

Particulate Air Pollution Exposure and C-reactive Protein During Early Pregnancy

Lee¹,

Talbott²,

Roberts³

et al. 2011

Epidemiology

102

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“…Furthermore, during her pregnancy, her CRP levels were increased almost three-fold in subject #II-8, which is similar to the two-to three-fold increase in CRP level observed in normal pregnancy during the second trimester. 27 The CRP level decreased after delivery and was further reduced by statin treatment (Fig. 4).…”

Section: Discussionmentioning

confidence: 90%

Complete Apo AI Deficiency in an Iraqi Mandaean Family: Case studies and review of the literature

Al-Sarraf

Al-Ghofaili

Sullivan

et al. 2010

Journal of Clinical Lipidology

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“…According to Casanueva & Viteri (2003) these oxidative stresses reached to the peaks by the second trimester of pregnancy and it may cause the death of fetus in the absence of antioxidant. Further, Fialová et al (2006) reported higher level AOPPs (advanced oxidation protein products), CRP (C-reactive protein) and ACA (anticardiolipin antibodies) and IgG in the 1st and 2nd trimesters which reflect a maternal response to inflammatory and oxidative stress in pregnant women. Similarly Toescu et al (2002) reported that last trimester of pregnancy was associated with the formation of susceptible, oxidisable particles (high LDL score) and an increase in oxidative damage and this may increase risk of cardiovascular disease.…”

Section: Introductionmentioning

confidence: 91%

Effects of pregnancy and disease stress on the antioxidative capacity of sheep and goat

Hayajneh¹,

Abdelqader²,

Irshaid³

2016

JEBAS

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Sheep and goat undergoes various stresses throughout their life cycle, among various causes of these stresses pregnancy and diseases are the most common one which widely affected these two ruminants. The aim of this study was to investigate the effect of pregnancy and disease stress on antioxidative capacity of the sheep and goat, which in turn screens the total health status of the animal under study. Forty goat and sheep females (20 each) in two groups viz 15 diseased & pregnant and 5 healthy females without pregnancy and diseases (control) were investigated for variations in the antioxidative capacity. Result of study revealed that acw value (the water soluble antioxidative capacity) was reported lowest in pregnant sheep (5.75mg/l), whereas this value was reported highest in the control group (7.08 mg/l) which concluded that stress caused by pregnancy or disease reduced the antioxidative capacity of goat and sheep as compared the control group. Similar trends were reported in the goat also.

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Oxidative stress and inflammation in pregnancy

Cited by 66 publications

References 22 publications

Particulate Air Pollution Exposure and C-reactive Protein During Early Pregnancy

Particulate Air Pollution Exposure and C-reactive Protein During Early Pregnancy

Complete Apo AI Deficiency in an Iraqi Mandaean Family: Case studies and review of the literature

Effects of pregnancy and disease stress on the antioxidative capacity of sheep and goat

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