Oxidative Stress and Inflammation in First-Episode Psychosis: A Systematic Review and Meta-analysis

Fraguas, David; Díaz‐Caneja, Covadonga M.; Ayora, Miriam; Hernández-Álvarez, Fabián; Rodríguez-Quiroga, Alberto; Recio, Sandra; Leza, Juan C.; Arango, Celso

doi:10.1093/schbul/sby125

Cited by 187 publications

(138 citation statements)

References 56 publications

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“…Most of the information about inflammation and oxidative/ nitrosative stress in SZ is from plasma or PBMC studies. These findings attempt to explore (indirectly) the inflammatory state of the brain and to find biomarkers for the disease (Miller et al, 2011;Fraguas et al, 2017). We analyzed the peripheral inflammation and oxidative/nitrosative stress in the NVHL model.…”

Section: Discussionmentioning

confidence: 99%

Risperidone Ameliorates Prefrontal Cortex Neural Atrophy and Oxidative/Nitrosative Stress in Brain and Peripheral Blood of Rats with Neonatal Ventral Hippocampus Lesion

et al. 2019

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Reduction of the dendritic arbor length and the lack of dendritic spines in the pyramidal cells of the prefrontal cortex (PFC) are prevalent pathological features in schizophrenia (SZ). Neonatal ventral hippocampus lesion (NVHL) in male rats reproduces these neuronal characteristics and here we describe how this is a consequence of BDNF/TrkB pathway disruption. Moreover, COX-2 proinflammatory state, as well as Nrf-2 antioxidant impairment, triggers oxidative/nitrosative stress, which also contributes to dendritic spine impairments in the PFC. Interestingly, oxidative/nitrosative stress was also detected in the periphery of NVHL animals. Furthermore, risperidone treatment had a neurotrophic effect on the PFC and antioxidant effects on the brain and periphery of NVHL animals; these cellular effects were related to behavioral improvement. Our data highlight the link between brain development and immune response, as well as several other factors to understand mechanisms related to the pathophysiology of SZ.

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Section: Discussionmentioning

confidence: 99%

Risperidone Ameliorates Prefrontal Cortex Neural Atrophy and Oxidative/Nitrosative Stress in Brain and Peripheral Blood of Rats with Neonatal Ventral Hippocampus Lesion

et al. 2019

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“…An accumulation of evidence indicates that the pathophysiology of schizophrenia is partially attributable to heightened OS [ 85 , 86 , 87 , 88 , 89 , 90 ]. Evidence of higher lipid peroxidation levels, changes in plasma antioxidant levels, and alterations in antioxidant enzyme activity have also been found in schizophrenia patients [ 91 ].…”

Section: Association Between Oxidative Stress and Schizophreniamentioning

confidence: 99%

Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia

Madireddy

2020

Brain Sciences

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The biochemical integrity of the brain is paramount to the function of the central nervous system, and oxidative stress is a key contributor to cerebral biochemical impairment. Oxidative stress, which occurs when an imbalance arises between the production of reactive oxygen species (ROS) and the efficacy of the antioxidant defense mechanism, is believed to play a role in the pathophysiology of various brain disorders. One such disorder, schizophrenia, not only causes lifelong disability but also induces severe emotional distress; however, because of its onset in early adolescence or adulthood and its progressive development, consuming natural antioxidant products may help regulate the pathogenesis of schizophrenia. Therefore, elucidating the functions of ROS and dietary antioxidants in the pathogenesis of schizophrenia could help formulate improved therapeutic strategies for its prevention and treatment. This review focuses specifically on the roles of ROS and oxidative damage in the pathophysiology of schizophrenia, as well as the effects of nutrition, antipsychotic use, cognitive therapies, and quality of life on patients with schizophrenia. By improving our understanding of the effects of various nutrients on schizophrenia, it may become possible to develop nutritional strategies and supplements to treat the disorder, alleviate its symptoms, and facilitate long-term recovery.

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“…3 But, it is important to note that inflammatory, oxidative stress and metabolic disturbances may precede the FEP and initiation of antipsychotic treatment. [4][5][6] There is also growing evidence regarding metabolic alterations induced by antipsychotic medication that increase the cardiovascular risk of the patients. Circulating Vascular Cell Adhesion molecule-1 (sVCAM-1) and Intercellular Adhesion Molecule-1 (sICAM-1) are well-known biomarkers of endothelial inflammation and dysfunction that are associated with an increased risk of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

<p>The Predictive Value of Endothelial Inflammatory Markers in the Onset of Schizophrenia</p>

Radu

Luca

Petrescu

et al. 2020

NDT

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This study aimed to assess the serum levels of intracellular adhesion molecule (sICAM-1), and vascular cell adhesion molecule (sVCAM-1), in the first psychotic episode schizophrenia (SZ) patients, before and after six months of antipsychotic treatment. Patients and Methods: The study included 50 patients with a first hospitalization for SZ and 50 healthy control subjects that were patient-matched regarding age, gender, body mass index and smoking status. The evaluation included the presence of cardiovascular risk factors, measurements of systolic and diastolic blood pressure, body mass index, smoking status, anklebrachial index, carotid intima-media thickness, and echocardiography. The Brief Psychiatric Rating Scale (BPRS) score was calculated for the patients. The plasma levels of fasting glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, sICAM-1 and sVCAM-1 were determined at baseline in all subjects and after six months of antipsychotic treatment. Thirty patients (60%) were treated with olanzapine and 20 (40%) with risperidone. Results: The average age of patients experiencing their first episode of SZ was 29.7±6.6 years, and 23 (46%) were men. The initial sICAM-1 levels of the patients were lower than those of the control group (P<0.0001), and increased after treatment (P=0.02), but remained lower than in the healthy controls (P=0.026). The initial levels of sVCAM-1 levels were higher in the patients (P<0.0001) and decreased after treatment (P<0.0001) to values that were similar to those of the control group (P=0.39). The only independent predictor of a baseline BPRS over 120 was the baseline sVCAM-1 level (P<0.0001). Antipsychotic treatment induced significant decreases in BPRS score (P<0.0001), in systolic (P=0.005) and diastolic (P<0.0001) blood pressure, in HDLc (P=0.02), as well as significant increases in blood glucose (P<0.01) and LDL-c (P<0.001), with no differences between olanzapine and risperidone. Conclusion: In the patients experiencing an FEP of SZ, the levels of sICAM-1 were lower, while the levels of sVCAM-1 were higher than in the healthy control subjects. The antipsychotics used in the treatment of schizophrenia increased sICAM-1 and decreased sVCAM. The baseline level of sVCAM-1 was an independent predictor of a BPRS score >120 at baseline.

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Oxidative Stress and Inflammation in First-Episode Psychosis: A Systematic Review and Meta-analysis

Cited by 187 publications

References 56 publications

Risperidone Ameliorates Prefrontal Cortex Neural Atrophy and Oxidative/Nitrosative Stress in Brain and Peripheral Blood of Rats with Neonatal Ventral Hippocampus Lesion

Risperidone Ameliorates Prefrontal Cortex Neural Atrophy and Oxidative/Nitrosative Stress in Brain and Peripheral Blood of Rats with Neonatal Ventral Hippocampus Lesion

Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia

<p>The Predictive Value of Endothelial Inflammatory Markers in the Onset of Schizophrenia</p>

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