Oxidative Stress and Inflammation: From Mechanisms to Therapeutic Approaches

Gambini, Juan; Stromsnes, Kristine

doi:10.3390/biomedicines10040753

Cited by 16 publications

(16 citation statements)

References 15 publications

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“…It is habitually accompanied by pain, redness, heat, and swelling. Two types of inflammation have been distinguished: acute and chronic inflammation [72]. To begin with, acute inflammation is short-term and only takes a few days to disappear.…”

Section: In Vitro Antioxidant and Anti-inflammatory Evoo Polyphenols ...mentioning

confidence: 99%

The Tower of Babel of Pharma-Food Study on Extra Virgin Olive Oil Polyphenols

Clodoveo

Muraglia

Crupi

et al. 2022

Foods

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Much research has been conducted to reveal the functional properties of extra virgin olive oil polyphenols on human health once EVOO is consumed regularly as part of a balanced diet, as in the Mediterranean lifestyle. Despite the huge variety of research conducted, only one effect of EVOO polyphenols has been formally approved by EFSA as a health claim. This is probably because EFSA’s scientific opinion is entrusted to scientific expertise about food and medical sciences, which adopt very different investigative methods and experimental languages, generating a gap in the scientific communication that is essential for the enhancement of the potentially useful effects of EVOO polyphenols on health. Through the model of the Tower of Babel, we propose a challenge for science communication, capable of disrupting the barriers between different scientific areas and building bridges through transparent data analysis from the different investigative methodologies at each stage of health benefits assessment. The goal of this work is the strategic, distinctive, and cost-effective integration of interdisciplinary experiences and technologies into a highly harmonious workflow, organized to build a factual understanding that translates, because of trade, into health benefits for buyers, promoting EVOOs as having certified health benefits, not just as condiments.

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Section: In Vitro Antioxidant and Anti-inflammatory Evoo Polyphenols ...mentioning

confidence: 99%

The Tower of Babel of Pharma-Food Study on Extra Virgin Olive Oil Polyphenols

Clodoveo

Muraglia

Crupi

et al. 2022

Foods

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“…The frontal lobe, known as the emotional center of the human body [ 127 ], is susceptible to damage, which can lead to emotional control disorders such as schizophrenia, mania, aggression and verbal abuse, ultimately manifesting as psychiatric conditions [ 128 ]. Depression is a severe mental illness that poses a significant threat to human health [ 129 ], and its pathogenesis is complex and diverse, with oxidative stress and inflammation being important pathological mechanisms [ 130 , 131 ]. Extensive evidence supports a close association between oxidative stress and depression.…”

Section: Reviewmentioning

confidence: 99%

Broadening horizons: ferroptosis as a new target for traumatic brain injury

Wei,

Yu,

Zhao

et al. 2024

Burns &Amp; Trauma

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Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, with ~50 million people experiencing TBI each year. Ferroptosis, a form of regulated cell death triggered by iron ion-catalyzed and reactive oxygen species-induced lipid peroxidation, has been identified as a potential contributor to traumatic central nervous system conditions, suggesting its involvement in the pathogenesis of TBI. Alterations in iron metabolism play a crucial role in secondary injury following TBI. This study aimed to explore the role of ferroptosis in TBI, focusing on iron metabolism disorders, lipid metabolism disorders and the regulatory axis of system Xc−/glutathione/glutathione peroxidase 4 in TBI. Additionally, we examined the involvement of ferroptosis in the chronic TBI stage. Based on these findings, we discuss potential therapeutic interventions targeting ferroptosis after TBI. In conclusion, this review provides novel insights into the pathology of TBI and proposes potential therapeutic targets.

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“…While the risk factors for dementia trigger widespread inflammation and oxidative stress (e.g., 86 , 87 ), it is also true that these 2 processes can result in more biological effects than enhanced calcium load in brain tissue and neurodegeneration (cf. 88 ). In fact, oxidative stress and inflammation each involve pathophysiological cascades associated with a wide range of pathologies and especially aging.…”

Section: Treating Brain Injury Neuroinflammation Oxidative Stress And...mentioning

confidence: 99%

“…Yet, when oxidative stress and/or inflammation are dysregulated, their action is harmful. 88 , 89 (In this situation, one corresponding example [of many] occurs in Alzheimer’s disease, where growing evidence links the “reactive oxygen species” (ROS)-mediated damages with molecular targets including mitochondrial dynamics/function, autophagic pathways, and proteostasis balance. 90 ) Accordingly, Khalil et al 91 found that Alzheimer’s disease impaired the interaction of HDL (and ApoA-I) with the SR-BI receptor, and their experimental results indicated that such patients had higher levels of oxidative stress.…”

Section: Treating Brain Injury Neuroinflammation Oxidative Stress And...mentioning

confidence: 99%

Nanotargeting of Drug(s) for Delaying Dementia: Relevance of Covid-19 Impact on Dementia

D'Arrigo

2020

Am J Alzheimers Dis Other Demen

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By incorporating appropriate drug(s) into lipid (biobased) nanocarriers, one obtains a combination therapeutic for dementia treatment that targets certain cell-surface scavenger receptors (mainly class B type I, or “SR-BI”) and thereby crosses the blood-brain barrier. The cardiovascular risk factors for dementia trigger widespread inflammation -- which lead to neurodegeneration, gradual cognitive/memory decline, and eventually (late-onset) dementia. Accordingly, one useful strategy to delay dementia could be based upon nanotargeting drug(s), using lipid nanocarriers, toward a major receptor class responsible for inflammation-associated (cytokine-mediated) cell signaling events. At the same time, the immune response and excessive inflammation, commonly observed in the very recent human coronavirus (COVID-19) pandemic, may accelerate the progression of brain inflammatory neurodegeneration—which increases the probability of post-infection memory impairment and accelerating progression of Alzheimer’s disease. Hence, the proposed multitasking combination therapeutic, using a (biobased) lipid nanocarrier, may also display greater effectiveness at different stages of dementia.

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Oxidative Stress and Inflammation: From Mechanisms to Therapeutic Approaches

Abstract: Oxidative stress and inflammation are two phenomena that are directly involved in practically all pathologies and especially in aging [...]

Cited by 16 publications

References 15 publications

The Tower of Babel of Pharma-Food Study on Extra Virgin Olive Oil Polyphenols

The Tower of Babel of Pharma-Food Study on Extra Virgin Olive Oil Polyphenols

Broadening horizons: ferroptosis as a new target for traumatic brain injury

Nanotargeting of Drug(s) for Delaying Dementia: Relevance of Covid-19 Impact on Dementia

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