Oxidative Stress and Inflammation Can Fuel Cancer

Vaidya, Foram U.; Chhipa, Abu Sufiyan; Sagar, Nibha; Pathak, Chandramani

doi:10.1007/978-981-15-1568-2_14

Cited by 27 publications

(20 citation statements)

References 211 publications

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“…In addition, tumor-promoting inflammation was also inhibited by CORM-2, as demonstrated by the reduction of serous levels of inflammatory markers (i.e., tumor necrosis factor alpha, IL-1β, and IL-6) in orthotopic lung cancer mice [ 70 ]. Intriguingly, growing body of literature has reported the involvement of ROS in the development of both genomic instability and inflammation [ 5 , 9 , 105 ]. Because CO-RMs have been documented as potent candidates in a variety of diseases owing to their broad activities, particularly anti-inflammation and antioxidant [ 20 , 25 ], it is rationale to believe that ROS may be an important signaling by which CO-RMs regulate two enabling characteristics of cancers.…”

Section: Mechanisms Behind the Anticancer Activities Of Co-rms: An Outlook From Ros Biology And Medicinementioning

confidence: 99%

“…Despite of remaining ambiguous, the discovery of the involvement of oxidative stress during the course of cancer can be considered a noticeable milestone in cancer biology. A series of reviews has reported that the disturbance of redox balance may result in numerous oncogenic cellular events, such as genome instability and mutations, uncontrolled cell proliferation, evasion of cell death, angiogenesis, invasiveness, and metastasis, among others [ [4] , [5] , [6] ]. On the other hand, chronic inflammation has also been shown to involve in multiple steps in carcinogenesis [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, chronic inflammation has also been shown to involve in multiple steps in carcinogenesis [ 7 , 8 ]. Moreover, it has been documented that oxidative stress can trigger chronic inflammation through the activation of various transcription factors that modulate the expression of a wide variety of growth factors, cytokines, chemokines, cell cycle regulatory molecules, so forth [ 5 , 9 ]. Interestingly, while oxidative stress can lead to inflammation, the opposite that is inflammation can induce oxidative stress may also occur [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine

Tuan

et al. 2021

Redox Biology

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Carbon monoxide (CO) is now well recognized a pivotal endogenous signaling molecule in mammalian lives. The proof-of-concept employing chemical carriers of exogenous CO as prodrugs for CO release, also known as CO-releasing molecules (CO-RMs), has been appreciated. The major advantage of CO-RMs is that they are able to deliver CO to the target sites in a controlled manner. There is an increasing body of experimental studies suggesting the therapeutic potentials of CO and CO-RMs in different cancer models. This review firstly presents a short but crucial view concerning the characteristics of CO and CO-RMs. Then, the anticancer activities of CO-RMs that target many cancer hallmarks, mainly proliferation, apoptosis, angiogenesis, and invasion and metastasis, are discussed. However, their anticancer activities are varying and cell-type specific. The aerobic metabolism of molecular oxygen inevitably generates various oxygen-containing reactive metabolites termed reactive oxygen species (ROS) which play important roles in both physiology and pathophysiology. Although ROS act as a double-edged sword in cancer, both sides of which may potentially have been exploited for therapeutic benefits. The main focus of the present review is thus to identify the possible signaling network by which CO-RMs can exert their anticancer actions, where ROS play the central role. Another important issue concerning the potential effect of CO-RMs on the aerobic glycolysis (the Warburg effect) which is a feature of cancer metabolic reprogramming is given before the conclusion with future prospects on the challenges of developing CO-RMs into clinically pharmaceutical candidates in cancer therapy.

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Section: Mechanisms Behind the Anticancer Activities Of Co-rms: An Outlook From Ros Biology And Medicinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine

Tuan

et al. 2021

Redox Biology

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“…The macrophages that dominate the chronic inflammatory microenvironment produce increased levels of ROS and RNI, which in turn interact with the DNA of proliferating epithelial cells and generate permanent genetic mutations leading to the malignant transformation. Excessive ROS/RNI production during the process of oxidative metabolism has been reported to promote the synthesis and secretion of inflammation-promoting cytokines such as tumor necrosis factor (TNF)-α, interferon-gamma (IFN-γ), and interleukin (IL)-6 [64,65]. Moreover, other inflammatory mediators such as chemokines, growth factors, and eicosanoids in tumor microenvironments contribute to inflammation-triggered tumor progression and metastasis via modulating the immune response, inhibiting apoptosis, inducing cell proliferation, and promoting the accumulation of oncogenic mutations [66].…”

Section: Esophagealmentioning

confidence: 99%

Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives

Dharmawansa

Hoskin

Rupasinghe

2020

IJMS

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Anthocyanins are a group of dietary polyphenols, abundant mainly in fruits and their products. Dietary interventions of anthocyanins are being studied extensively related to the prevention of gastrointestinal (GI) cancer, among many other chronic disorders. This review summarizes the hereditary and non-hereditary characteristics of GI cancers, chemistry, and bioavailability of anthocyanins, and the most recent findings of anthocyanin in GI cancer prevention through modulating cellular signaling pathways. GI cancer-preventive attributes of anthocyanins are primarily due to their antioxidative, anti-inflammatory, and anti-proliferative properties, and their ability to regulate gene expression and metabolic pathways, as well as induce the apoptosis of cancer cells.

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“…Excess ROS can cause cellular damage by reacting with cellular components such as proteins, lipids, or DNA [ 3 ]. In the human body, oxidative stress plays a crucial role in the onset of several diseases including cancer, diabetes, cardiovascular and respiratory diseases [ 4 , 5 ]. Oxidative stress can both be a cause and a consequence of inflammation.…”

Section: Introductionmentioning

confidence: 99%

Rapid Liquid Chromatography—Tandem Mass Spectrometry Analysis of Two Urinary Oxidative Stress Biomarkers: 8-oxodG and 8-isoprostane

et al. 2020

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Human biomonitoring of oxidative stress relies on urinary effect biomarkers such as 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), and 8-iso-prostaglandin F2α (8-isoprostane); however, their levels reported for similar populations are inconsistent in the scientific literature. One of the reasons is the multitude of analytical methods with varying degrees of selectivity used to quantify these biomarkers. Single-analyte methods are often used, requiring multiple injections that increase both time and cost. We developed a rapid ultra-high-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) method to quantify both urinary biomarkers simultaneously. A reversed-phase column using a gradient consisting of 0.1% acetic acid in water and 0.1% acetic acid in methanol/acetonitrile (70:30) was used for separation. The MS detection was by positive (8-oxodG) and negative (8-isoprostane) ion-mode by multiple reaction monitoring. Very low limit of detection (<20 pg/mL), excellent linearity (R2 > 0.999), accuracy (near 100%), and precision (CV < 10%) both for intra-day and inter-day experiments were achieved, as well as high recovery rates (>91%). Matrix effects were observed but were compensated by using internal standards. Our newly developed method is applicable for biomonitoring studies as well as large epidemiological studies investigating the effect of oxidative damage, as it requires only minimal clean up using solid phase extraction.

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Oxidative Stress and Inflammation Can Fuel Cancer

Cited by 27 publications

References 211 publications

The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine

The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine

Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives

Rapid Liquid Chromatography—Tandem Mass Spectrometry Analysis of Two Urinary Oxidative Stress Biomarkers: 8-oxodG and 8-isoprostane

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