Oxidative stress and immunological alteration in women with preeclampsia

Silva, Danilla Michelle Costa e; Marreiro, Dilina do Nascimento; Neto, José Machado Moita; Brito, José Araújo; Neta, Eunice Alves da Silva; Matias, Juliana Paz; Sampaio, Fabiane Araújo; Nogueira, Nadir do Nascimento

doi:10.3109/10641955.2013.806540

Cited by 21 publications

(9 citation statements)

References 34 publications

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“…From these findings, it is clear their involvement in the pathophysiology of the disease and that their levels increase according to the severity of PE. In addition, experimental studies [40, 62, 63] also show an increase in levels of inflammatory factors in PE, which is associated with endothelial dysfunction, also observed, as well as the protective role of IL-10, when administered in an appropriate dose/time [64, 65].…”

Section: Pe Vs Inflammatory Biomarkersmentioning

confidence: 99%

Cross-Talk between Oxidative Stress and Inflammation in Preeclampsia

Tenório

Ferreira

Moura

et al. 2019

Oxidative Medicine and Cellular Longevity

144

105

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The occurrence of hypertensive syndromes during pregnancy leads to high rates of maternal-fetal morbidity and mortality. Amongst them, preeclampsia (PE) is one of the most common. This review aims to describe the relationship between oxidative stress and inflammation in PE, aiming to reinforce its importance in the context of the disease and to discuss perspectives on clinical and nutritional treatment, in this line of research. Despite the still incomplete understanding of the pathophysiology of PE, it is well accepted that there are placental changes in pregnancy, associated with an imbalance between the production of reactive oxygen species and the antioxidant defence system, characterizing the placental oxidative stress that leads to an increase in the production of proinflammatory cytokines. Hence, a generalized inflammatory process occurs, besides the presence of progressive vascular endothelial damage, leading to the dysfunction of the placenta. There is no consensus in the literature on the best strategies for prevention and treatment of the disease, especially for the control of oxidative stress and inflammation. In view of the above, it is evident the important connection between oxidative stress and inflammatory process in the pathogenesis of PE, being that this disease is capable of causing serious implications on both maternal and fetal health. Reports on the use of anti-inflammatory and antioxidant compounds are analysed and still considered controversial. As such, the field is open for new basic and clinical research, aiming the development of innovative therapeutic approaches to prevent and to treat PE.

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Section: Pe Vs Inflammatory Biomarkersmentioning

confidence: 99%

Cross-Talk between Oxidative Stress and Inflammation in Preeclampsia

Tenório

Ferreira

Moura

et al. 2019

Oxidative Medicine and Cellular Longevity

144

105

View full text Add to dashboard Cite

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“…But, the largest significant difference was verify between 11 and 16 days after emergence, where all the treatments with physical protector, independently of the filter, originate superior values when compared to the one observed in the absence of the physical protector, being equal at 115, 107 and 100% for the blue protector (BLUE), transparent protector (TRANSP), and red protector (RED), respectively. This way, the higher seedlings emergence may have occur because of the increase of the temperature and phytochrome influence, probably because, the physical protectors may have allowed the canafistula seeds a higher period of time in the optimal temperature for germination, that would explain the maximal germination percentage in a very short time (Silva et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

Influence of physical protectors with different filters on the initial development of Peltophorum dubium (Spreng.) Taub seedlings

Klein¹,

Rodrigues²,

Guimarães³

et al. 2014

Afr. J. Agric. Res.

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The use of physical protectors has been considered as an efficient technique for tillage farming of different species, mainly native ones. Based on the importance of the species, Peltophorum dubium for revegetation of degraded areas, this study evaluated the emergence, survival and initial development of P. dubium seedlings under the influence of physical protectors with different filters. Thus, the following treatments were adopted: absence of physical protector (APP), transparent physical protector (TPP), transparent physical protector + blue cellophane (BPP) and transparent physical protector + red cellophane (RPP). The evaluated characteristics were: emergence velocity index (EVI), seedling survival and emergence percentage, plant height, leaf area and root collar diameter. All of these physical protectors increased the mean values of EVI and survival. In conclusion, the emergence speed and initial development of P. dubium (Spreng.) seedlings grown in the interior of physical protectors, independent on the filters, presented positive results. The reduction on the light intensity interferes positively in the initial growth of these plants.

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“…13,14 Preeclampsia is also associated with oxidative stress. 15 A drug that can decrease production of sFlt-1 and sEng, and reduce endothelial dysfunction and oxidative stress could provide a potential treatment for preeclampsia. 16 Esomeprazole, a PPI widely used in pregnancy to treat gastric reflux, has shown promise as a potential candidate therapeutic in preclinical studies.…”

Section: Discussionmentioning

confidence: 99%

Effect of esomeprazole on maternal serum soluble fms-like tyrosine kinase-1 and endoglin in patients with early-onset preeclampsia

et al. 2021

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Objective: This study evaluates the effect of esomeprazole on the maternal serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng) in patients with early-onset preeclampsia.Methods: A randomized, double-blind, placebo-controlled trial was carried out in a tertiary University hospital between March 2018, and September 2019 (Clinical Trials.Gov: NCT03213639). The study included women between 28 and 31+6 weeks gestational age who had been diagnosed as preeclampsia without severe features. They were randomly assigned in a 1:1 ratio into an esomeprazole group, which received esomeprazole 40 mg orally once a day, and a placebo group, which received one placebo tablet daily. Blood samples were obtained to assess levels of serum sFlt-1and sEng using ELISA testing. The primary outcome was the difference between the mean serum level of sFlt-1 and sEng at the start of treatment and at the termination of pregnancy in both groups.Results: Eighty-eight patients were randomly assigned into both groups (44 in each). No statistically significant difference was found in the levels of sFlt-1 between both groups at admission and termination of pregnancy. The number of days of treatment for the esomeprazole group was slightly longer than the placebo group (11.4Â±9.4 vs. 10.3Â±6.3 days, P=0.515). No statistically significant difference in the rate of maternal and fetal complications occurred between the two groups. No side effects from the study medications were reported.Conclusions: Esomeprazole, at the dosage used in this study did not effectively lower the serum levels of sFlt-1 and sEng in patients with early-onset preeclampsia. Furthermore, it did not prolong the duration of pregnancy, nor did it decrease maternal or fetal complications.

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Oxidative stress and immunological alteration in women with preeclampsia

Abstract: The MDA is a nonspecific marker for oxidative stress in preeclampsia, and the gestantes with preeclampsia have immune dysfunction.

Cited by 21 publications

References 34 publications

Cross-Talk between Oxidative Stress and Inflammation in Preeclampsia

Cross-Talk between Oxidative Stress and Inflammation in Preeclampsia

Influence of physical protectors with different filters on the initial development of Peltophorum dubium (Spreng.) Taub seedlings

Effect of esomeprazole on maternal serum soluble fms-like tyrosine kinase-1 and endoglin in patients with early-onset preeclampsia

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