Oxidative Stress and Hypertensive Diseases

Synergistic therapeutic effects of Duzhong Jiangya Tablets and amlodipine besylate combination in spontaneously hypertensive rats using 1H‐NMR‐ and MS‐based metabolomics

“…Various metabolic processes in the body produce reactive oxygen species (ROS) that are associated with oxidative stress. ROS raises blood pressure by inhibiting the expression of endothelial nitric oxide synthase and consuming large amounts of NO (Loperena & Harrison, ). Choline, a precursor of serine, produces LysoPC via the metabolism of glycerophospholipid and the catalysis of phospholipase (Kougias et al, ).…”

“…Various metabolic processes in the body produce reactive oxygen species (ROS) that are associated with oxidative stress. ROS raises blood pressure by inhibiting the expression of endothelial nitric oxide synthase and consuming large amounts of NO (Loperena & Harrison, 2017 """ and "#" means the metabolite is upregulated and downregulated, "-"means that the metabolite did not produce significant change; p-values are determined by paired-sample t-test, and less than 0.05 was considered significant. Abbreviations: ABT, amlodipine besylate treatment group; CBT, combination treatment group; Con, control group; EHT, Duzhong Jiangya Tablet treatment group; Hyp, hypertension model group.…”

Fermented goat milk consumption improves cardiovascular health during anemia recovery

“…In addition, consumption of fermented goat milk is more beneficial in overcoming the effects of Fe deficiency, increasing key proteins of intestinal Fe metabolism, enhancing Fe digestive and metabolic utilization, increasing Fe deposits in target organs and favoring the recovery of hematological parameters . Finally, it has also been reported that fermented goat milk consumption induced a protective effect in the tissues, increasing total antioxidant status (TAS) and decreasing the oxidative damage biomarkers, protecting main cell bioconstituents (lipids, protein, prostaglandins, and DNA) from evoked oxidative damage during anemia recovery, and it is well known that oxidative stress is one of the major triggers for developing CD . However, in spite of the role of Fe deficiency on CD, to date no studies have directly tested the effect of fermented milks on cardiovascular health during anemia recovery.…”

Ameliorative effect of Rutin on sodium fluoride‐induced hypertension through modulation of Kim‐1/NF‐κB/Nrf2 signaling pathway in rats

“…The generation of ROS/RNS and oxidative stress has been implicated in the pathogenesis of hypertension . Similarly, ROS/RNS have been reported to cause endothelial dysfunction, vascular remodeling, arterial stiffness, arteriosclerosis, and hypertension .…”