Oxidative stress and glaucoma: injury in the anterior segment of the eye

Saccà, Sergio Claudio; Izzotti, Alberto

doi:10.1016/s0079-6123(08)01127-8

Cited by 129 publications

(105 citation statements)

References 171 publications

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“…However, basic research regards both of them as neurodegenerative diseases, where there is a similar signaling pathway of apoptosis resulting in the loss of RGCs 59,100. In addition, similar cellular or protein responses, such as gliosis, ET-1 increase, glutamate toxicity, oxidative stress, etc, are involved in the mechanism 101,102. Even similar gene mutation is found both in NTG and POAG based on the epidemiological evidence 103–105.…”

Section: The Current Concepts Regarding the Relationship Between Ntg mentioning

confidence: 99%

The current research status of normal tension glaucoma

Mi¹,

Yuan²,

So³

2014

CIA

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Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a therapeutic target for NTG management.

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Section: The Current Concepts Regarding the Relationship Between Ntg mentioning

confidence: 99%

The current research status of normal tension glaucoma

Mi¹,

Yuan²,

So³

2014

CIA

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“…Oxidative stress plays a role in glaucoma development initially by damaging TM cells, then altering nitric oxide and endothelin homeostasis, and finally contributing to ganglional cell death. 6 Although much experimental evidence indicates that oxidative damage is implicated in the pathogenesis of primary open-angle glaucoma (POAG), the source of such damageremainstobeidentified.Noenvironmental sources of oxidative stress, such as cigarette smoke or radiation, have been involved inglaucomapathogenesis. 7 Mitochondriaare the most important endogenous source of reactive oxygen species in cells.…”

Section: He Trabecular Meshworkmentioning

confidence: 99%

Mitochondrial Damage in the Trabecular Meshwork of Patients With Glaucoma

et al. 2010

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“…Numerous studies have identified oxidative damage as an important event in the pathogenesis of ocular diseases such as macular degeneration (Kinnunen et al, 2011), cataract (Varma et al, 2011), and glaucoma (Abu-Amero et al, 2006; Alvarado et al, 1981; Chang, 2006; Chen and Kadlubar, 2003; Ferreira et al, 2004; Gabelt and Kaufman, 2005; Holekamp et al, 2005; Izzotti et al 2003; Izotti et al, 2006; Izzotti et al, 2009; Kong et al, 2009; Liton et al, 2009; Sacca et al, 2005; Sacca et al, 2007; Sacca and Izzotti, 2008; Shui et al, 2006; Siegfried et al, 2010; Tomarev, 2001; Wang et al, 2001; Zhou and Yue, 1999). Two important hemodynamic parameters of oxygen metabolism include oxygen partial pressure ( p O 2 ) and oxygen saturation of hemoglobin (sO 2 ).…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic tomography imaging and estimation of oxygen saturation of hemoglobin in ocular tissue of rabbits

Hennen

Xing

Shui

et al. 2015

Experimental Eye Research

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This study evaluated in vivo imaging capabilities and safety of qualitative monitoring of oxygen saturation of hemoglobin (sO2) of rabbit ciliary body tissues obtained with acoustic resolution (AR) photoacoustic tomography (PAT). AR PAT was used to collect trans-scleral images from ciliary body vasculature of seven New Zealand White rabbits. The PAT sO2 measurements were obtained under the following conditions: when systemic sO2 as measured by pulse oximetry was between 100% and 99% (level 1); systemic sO2 as measured by pulse oximetry was between 98% and 90% (level 2); and systemic sO2 as measured by pulse oximetry was less than 90% (level 3). Following imaging, histological analysis of ocular tissue was conducted to evaluate for possible structural damage caused by the AR PAT imaging. AR PAT was able to resolve anatomical structures of the anterior segment of the eye, viewed through the cornea or anterior sclera. Histological studies revealed no ocular damage. On average, sO2 values (%) obtained with AR PAT were lower than sO2 values obtained with pulse oximetry (all p<0.001): 86.28±4.16 versus 99.25±0.28, 84.09±1.81 vs. 95.3±2.6, and 64.49±7.27 vs. 71.15±10.21 for levels 1, 2 and 3 respectively. AR PAT imaging modality is capable of qualitative monitoring for deep tissue sO2 in rabbits. Further studies are needed to validate and modify the AR PAT modality specifically for use in human eyes. Having a safe, non-invasive method of in vivo imaging of sO2 in the anterior segment is important to studies evaluating the role of oxidative damage, hypoxia and ischemia in pathogenesis of ocular diseases.

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Oxidative stress and glaucoma: injury in the anterior segment of the eye

Cited by 129 publications

References 171 publications

The current research status of normal tension glaucoma

The current research status of normal tension glaucoma

Mitochondrial Damage in the Trabecular Meshwork of Patients With Glaucoma

Photoacoustic tomography imaging and estimation of oxygen saturation of hemoglobin in ocular tissue of rabbits

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