Oxidative stress and genotoxic effect of zinc oxide nanoparticles in freshwater snail Lymnaea luteola L.

Ali, Daoud; Alarifi, Saud; Kumar, Sudhir; Ahamed, Maqusood; Siddiqui, Maqsood A.

doi:10.1016/j.aquatox.2012.07.012

Cited by 117 publications

(51 citation statements)

References 37 publications

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“…Treatment with ZnO nanoparticles aggravated lipid peroxidation status particularly at the highest dose (10 mg/kg) in both healthy and diabetic rats, which indicated toxic nature of the nanoparticle. There are a growing number of studies showing that ZnO nanoparticles can generate ROS and consequently induce lipid peroxidation (26,27,43). We also observed that zinc sulfate protected lipid peroxidation and ROS generation evidenced by a significant reduction of MDA level in diabetic rats.…”

Section: Discussionsupporting

confidence: 49%

“…A number of in vitro and in vivo studies have found varying responses of catalase to increased amount of ROS production induced by ZnO. Some of them showed elevated activity (31,43,56), whereas others exhibited suppressed activity (57,58). In our study, although ZnO nanoparticles could relatively restore catalase activities in diabetic rats, however, severely inhibited the enzyme activity in healthy ones.…”

Section: Discussioncontrasting

confidence: 36%

“…With respect to ZnO-receiving animals, we found a significant reduction of GSH-Px activity, at higher doses (3 and 10 mg/kg). Ali and coworkers reported that ZnO treatment to fresh water snail significantly depressed GSH-Px activity and its substrate levels (GSH) in a time-and dose-dependent fashion (43). Additionally, under oxidative stress condition, glutathione (GSH) is consumed by the glutathione-related enzymes (such as GSH-Px) to detoxify peroxides produced due to increased lipid peroxidation (53).…”

Section: Discussionmentioning

confidence: 99%

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Comparative Study of Antidiabetic Activity and Oxidative Stress Induced by Zinc Oxide Nanoparticles and Zinc Sulfate in Diabetic Rats

Nazarizadeh

Asri-Rezaie

2015

AAPS PharmSciTech

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Abstract. In the current study, antidiabetic activity and toxic effects of zinc oxide nanoparticles (ZnO) were investigated in diabetic rats compared to zinc sulfate (ZnSO 4 ) with particular emphasis on oxidative stress parameters. One hundred and twenty male Wistar rats were divided into two healthy and diabetic groups, randomly. Each major group was further subdivided into five subgroups and then orally supplemented with various doses of ZnO (1, 3, and 10 mg/kg) and ZnSO 4 (30 mg/kg) for 56 consecutive days. ZnO showed greater antidiabetic activity compared to ZnSO 4 evidenced by improved glucose disposal, insulin levels, and zinc status. The altered activities of erythrocyte antioxidant enzymes as well as raised levels of lipid peroxidation and a marked reduction of total antioxidant capacity were observed in rats receiving ZnO. ZnO nanoparticles acted as a potent antidiabetic agent, however, severely elicited oxidative stress particularly at higher doses.

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Section: Discussionsupporting

confidence: 49%

Section: Discussioncontrasting

confidence: 36%

Section: Discussionmentioning

confidence: 99%

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Comparative Study of Antidiabetic Activity and Oxidative Stress Induced by Zinc Oxide Nanoparticles and Zinc Sulfate in Diabetic Rats

Nazarizadeh

Asri-Rezaie

2015

AAPS PharmSciTech

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“…[23] And a dose dependent increase in DNA damage in human sperm cells under pre-irradiated and simultaneous irradiation condition. [12] Similarly, another study reported by Ali D et al 2012 [24] in digestive gland cells treated with ZnO NPs at concentration of 32 µg/mL for 24 and 96 hours elicited DNA damage observed by comet assay. The present result also contradicts with the in vitro comet assay done on HEp-2 cells by Osman IF et al 2010 [25] where a concentration and time dependent increase in DNA damage was observed upon treatment with ZnO NPs.…”

Section: Discussionmentioning

confidence: 99%

Genotoxic and Histopathological Evaluation of Zinc Oxide Nanorods in Vivo in Swiss Albino Mice

Bollu¹,

Soren²,

Jamil³

et al. 2016

jemds

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BACKGROUNDZinc oxide (ZnO) nanoparticles are manufactured worldwide in large quantities for use in wide range of applications including pigments and cosmetic manufacturing. Although ZnO is chemically inert, ZnO nanoparticles can cause negative health effects. However, the mechanism involved in ZnO induced genotoxicity and carcinogenicity has not been clearly defined and are poorly studied in vivo.

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“…Moreover, we observed a significant correlation between the TI values in tissues of mussels and the concentrations of zinc, copper, iron, and arsenic at the exposure sites. Since zinc, copper, and arsenic are known to induce genotoxic effects in aquatic organisms [63][64][65][66], it is reasonable to conclude that the genotoxic responses observed in our study were mainly caused by pollution with heavy metals. However, we cannot exclude the contribution of other pollutants at the exposure sites.…”

Section: Genotoxicity Assessment: Active Biomonitoringmentioning

confidence: 90%

Genotoxicological Studies of Lower Stretch of the Sava River

Vuković-Gačić

Kolarević

Sunjog

et al. 2014

The Handbook of Environmental Chemistry

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Genotoxicity monitoring of the lower stretch of the Sava River was performed by the combined approach of in situ assessment of genotoxicity and active biomonitoring of two species of mussels from the Unionidae family, Unio pictorum and Unio tumidus. Genotoxic response was studied using comet assay on hemocytes. For active biomonitoring, the mussels were acclimated to controlled laboratory conditions for 10 days and then exposed at two sites in the Sava River in the area of the city of Belgrade. Hemolymph of exposed specimens of each species was taken after 7, 14, and 30 days of exposure. For in situ assessment, the mussels were collected from five sites in the lower flow of the Sava River. The mussels were sampled immediately after the acclimation served as controls in both types of monitoring procedures. The results of our studies indicated the presence of genotoxic pollution at all studied sites at the Sava River. The level of DNA damage varied at different sites depending on the source and level of pollution. The response to genotoxic pollution was evident at the site in the urban area of Belgrade city, as well as at the sites far from the large urban settlements, suggesting that the lower flow of the Sava River is under pollution pressure.

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Oxidative stress and genotoxic effect of zinc oxide nanoparticles in freshwater snail Lymnaea luteola L.

Cited by 117 publications

References 37 publications

Comparative Study of Antidiabetic Activity and Oxidative Stress Induced by Zinc Oxide Nanoparticles and Zinc Sulfate in Diabetic Rats

Comparative Study of Antidiabetic Activity and Oxidative Stress Induced by Zinc Oxide Nanoparticles and Zinc Sulfate in Diabetic Rats

Genotoxic and Histopathological Evaluation of Zinc Oxide Nanorods in Vivo in Swiss Albino Mice

Genotoxicological Studies of Lower Stretch of the Sava River

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