Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma

Ercan, Hulya; Birben, Esra; Dizdar, Evrim Alyamaç; Keskin, Özlem; Karaaslan, Çağatay; Soyer, Özge; Dut, Raziye; Saçkesen, Cansın; Besler, Halit Tanju; Kalaycı, Ömer

doi:10.1016/j.jaci.2006.08.012

Cited by 142 publications

(110 citation statements)

References 51 publications

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“…Since GSH is an important component that acts to scavenge ROS and regenerate other antioxidants, GSH depletion may represent increased oxidative stress in GSTP1 Val105 allele carriers. Similar to our findings, Ercan et al (34) reported that asthma patients with homozygous GSTP1 Val105 genotypes have lower GSH concentrations compared to patients with other genotypes. The Ile to Val substitution at position 105 results in steric restriction of the putative binding site (H-site) due to shifts in the side chains of several amino acids.…”

Section: Discussionsupporting

confidence: 92%

Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children

Chung

Shin

2009

Clinical Chemistry and Laboratory Medicine

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Background: Glutathione S-transferase (GST) enzymes are critical for detoxifying reactive oxygen species (ROS) and their products which have been implicated in the pathology of inflammatory diseases such as atopic dermatitis (AD). Methods:We investigated the effects of genetic polymorphisms of GST on the risk of AD in preschool age children. Biomarkers for oxidative stress were also evaluated with respect to GST genotype. Results: The GSTP1 Val105 allele was significantly associated with an increased risk of AD wodds ratio (OR)s1.62, p-0.05x. The combination of the GSTP1 Val105 allele and the GSTT1 null genotype further increased this risk by 2.3-fold (p-0.01). No association was observed for the GSTM1 null or GSTT1 null genotype alone. In children with AD, blood total antioxidant capacity was significantly less (p-0.001), while malondialdehyde was higher (ps0.12). Children with the GSTP1 Val105 allele had significantly lower concentrations of erythrocyte glutathione compared to GSTP1 Ile/Ile homozygotes (ps0.03). Conclusions: Our study suggests that the GSTP1 Val105 allele is an important determinant of susceptibility to AD in preschool age children and increased oxidative stress may play a role in the pathogenesis of AD.

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Section: Discussionsupporting

confidence: 92%

Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children

Chung

Shin

2009

Clinical Chemistry and Laboratory Medicine

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“…Host antioxidant systems are generally activated in response to the oxidant attack, but individuals have different capacities of antioxidant defense which are, in part, genetically determined. 41 Ercan et al 42 showed that there were genetic differences in the antioxidant response. Other studies have shown that as oxidative stress increases so the antioxidant capacity increases as a protective mechanism.…”

Section: Discussionmentioning

confidence: 99%

Oxidative status and paraoxonase activity in children with asthma

Çakmak¹,

Zeyrek²,

Ataş³

et al. 2009

CIM

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Objective: To compare paraoxonase activity and changes in oxidative status in asthmatic children and healthy children by determining serum paraoxonase activity and total oxidative status, total antioxidant capacity and lipid hydroperoxidation. Methods: Forty two asthmatic children were compared with 32 healthy children of similar age and sex. To evaluate the paraoxonase and oxidative status, total antioxidant capacity and lipid hydroperoxidation were examined. Serum paraoxonase activity was evaluated by measuring the rate of paraoxon hydrolosis. Oxidative status was evaluated by the method developed by Erel. Lipid hydroperoxide was measured by an iodometric method. Results: In comparison with the healthy control group, the paraoxonase activity of the asthmatic children was found to be low (163.7 ± 73.0 (U/L) and 349.2 ± 153.9 (U/L), P = 0.002) and total oxidant status (9.0 ± 3.5 µmol H2O2 Eq/L and 13.4 ± 7.0 µmol H2O2 Eq/L, P =0.002), total antioxidant capacity (5.5 ± 2.5 µmol Trolox Eq/L and 1.0 ± 0.6 µmol Trolox Eq/L, P < 0.001), and lipid hydroperoxidation values (9.9 ± 3.4 µmol H2O2 Eq/L and 4.4 ± 1.5 µmol H2O2 Eq/L, P < 0.001) were found to be high. The high density lipoprotein (HDL) concentration of the asthmatic children was lower than that in the control group (40.1 ± 9.2 mg/dl and 54.5 ± 15.9 mg/dl, P < 0.001) Conclusion: In asthmatic children, when total oxidant status, total antioxidant capacity and lipid hydroperoxidation levels increase, paraoxonase activity decreased.Coronary heart disease (CHD) is a major killer and the most common cause of mortality and morbidity in the world. 1 It usually involves middle and older age groups but, recently, the incidence of CHD in younger individuals has been increasing. 2 Atherosclerosis is a process that starts in childhood and has a long preclinical phase before leading to clinical manifestations which usually appear in middle age. 3 Changes in the peripheral vascular endothelium are the earliest signs of atherosclerosis and CHD. 4 This has been demonstrated in asymptomatic children and young adults who are healthy but carry risk factors for atherosclerosis (e.g., high cholesterol, smoking, diabetes). 5 HDL retards the accumulation of lipid peroxides on LDL cholesterol 6 apparently due to paraoxonase which is an enzyme located on HDL particles. 7 Paraoxonase has two functions. First, it contributes to detoxification of organophosphorous compounds, including the pesticide paraoxon. Secondly, it hydrolyzes lipid peroxides and prevents LDL oxidation. 8 In both asthma and atherosclerosis, leukotrienes, which are potential inflammation mediators, play a role. 9,10 Some studies have suggested that asthma itself could be a risk factor for stroke and heart ORIGINAL RESEARCH

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“…159,160 Children with asthma have higher plasma levels of MDA and 8-isoprostanes compared to those of healthy controls. 161 Asthmatic subjects with more obstructed airways have a higher degree of oxidative stress. 162 Obesity-mediated oxidative stress may affect the lung function of asthmatic subjects by airway inflammation and thus reduce the effectiveness of inhaled corticosteroids.…”

Section: Figmentioning

confidence: 99%

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

Manna

Jain

2015

Metabolic Syndrome and Related Disorders

743

486

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Obesity is gaining acceptance as a serious primary health burden that impairs the quality of life because of its associated complications, including diabetes, cardiovascular diseases, cancer, asthma, sleep disorders, hepatic dysfunction, renal dysfunction, and infertility. It is a complex metabolic disorder with a multifactorial origin. Growing evidence suggests that oxidative stress plays a role as the critical factor linking obesity with its associated complications. Obesity per se can induce systemic oxidative stress through various biochemical mechanisms, such as superoxide generation from NADPH oxidases, oxidative phosphorylation, glyceraldehyde auto-oxidation, protein kinase C activation, and polyol and hexosamine pathways. Other factors that also contribute to oxidative stress in obesity include hyperleptinemia, low antioxidant defense, chronic inflammation, and postprandial reactive oxygen species generation. In addition, recent studies suggest that adipose tissue plays a critical role in regulating the pathophysiological mechanisms of obesity and its related co-morbidities. To establish an adequate platform for the prevention of obesity and its associated health risks, understanding the factors that contribute to the cause of obesity is necessary. The most current list of obesity determinants includes genetic factors, dietary intake, physical activity, environmental and socioeconomic factors, eating disorders, and societal influences. On the basis of the currently identified predominant determinants of obesity, a broad range of strategies have been recommended to reduce the prevalence of obesity, such as regular physical activity, ad libitum food intake limiting to certain micronutrients, increased dietary intake of fruits and vegetables, and meal replacements. This review aims to highlight recent findings regarding the role of oxidative stress in the pathogenesis of obesity and its associated risk factors, the role of dysfunctional adipose tissue in development of these risk factors, and potential strategies to regulate body weight loss/gain for better health benefits.

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Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma

Cited by 142 publications

References 51 publications

Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children

Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children

Oxidative status and paraoxonase activity in children with asthma

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

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