Oxidative stress and enzymic–non-enzymic antioxidant responses in children with acute pneumonia

Cemek, Mustafa; Çaksen, Hüseyîn; Bayiroğlu, Fahri; Cemek, Fatma; Dede, Semiha

doi:10.1002/cbf.1220

Cited by 47 publications

(42 citation statements)

References 25 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The presence of clinical pathologies 37 , the clinical condition of the patient before arriving at the operating room, the surgical trauma itself 38,39 , and fasting, mentioned earlier, are important factors in the promotion of this imbalance. A particular clinical situation involving the use of sevoflurane should not be forgotten: the use of this halogenated compound in individuals with erythrocyte deficiency of G6PD 40 .…”

Section: Discussionmentioning

confidence: 98%

Avaliação de parâmetros antioxidantes em ratos tratados com sevoflurano

Bezerra¹,

Vale²,

Macedo³

et al. 2010

Rev. Bras. Anestesiol.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Avaliação de parâmetros antioxidantes em ratos tratados com sevoflurano

Bezerra¹,

Vale²,

Macedo³

et al. 2010

Rev. Bras. Anestesiol.

View full text Add to dashboard Cite

show abstract

“…Others studies have also demonstrated an increase of lipid peroxidation products in whole blood of these patients. Accordingly, increased serum MDA levels in acute pulmonary infection have been reported in both children (Cemek et al, 2006), and in adult patients . The molecular mechanism of damage in CAP included various mediators.…”

Section: Discussionmentioning

confidence: 99%

“…In CAP, the role of glutathione in the pathogenesis of microorganism invasion or antioxidant non-enzymatic response has not been characterized. Cemek et al (2006), studied antioxidant status in children with acute pneumonia, fi nding that all antioxidant compounds were decreased, i.e. vitamin C, vitamin E and GSH levels, compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

Relationship between severity of adult community-acquired pneumonia and impairment of the antioxidant defense system

Castillo

Carrasco

Álvarez³

et al. 2013

Biol. Res.

View full text Add to dashboard Cite

Oxidant/antioxidant imbalance has been reported in some infectious diseases, including community-acquired pneumonia (CAP). The aim was to assess the antioxidant status in adults with CAP and its relationship with clinical severity at admission. Fifty-nine patients with CAP were enrolled and categorized at admission by the FINE score, from July 2010 to October 2012. In the same period 61 controls were enrolled. Plasma samples were obtained at admission for determination of the ferric reducing ability of plasma (FRAP) and lipid peroxidation (8-isoprostane). Erythrocyte reduced (GSH)/oxidized (GSSG) glutathione, malondialdehyde (MDA) and antioxidant enzyme activity were assessed. Antioxidant status in adults with CAP represented by FRAP and the GSH/GSSG ratio were 16.8% (p=0.03) and 39.7% (p=0.04) lower than control values, respectively. In addition, FRAP values showed a positive correlation with GSH/GSSG ratio (r=0.852; p<0.02; n=59). The CAP group showed greater lipid peroxidation in both plasma and erythrocytes. The FINE score correlated negatively with FRAP (r= -0.718; p<0.05; n=59) and positively with MDA and F2 isoprostane levels (r=0.673; p<0.05; n=59; r=0.892; p<0.01; n=59, respectively). Antioxidant status alterations correlated with clinical severity. The FRAP assay and lipid peroxidation biomarkers may provide a useful parameter for estimating the severity and the clinical outcome of patients with CAP.

show abstract

“…24 Serum TAS was also reported to be decreased in pneumonia patients, with the decline associated with increased severity of the disease. 25 Antioxidant molecules can prevent or inhibit the aforementioned harmful reactions. Although serum concentrations of different antioxidants can be measured separately, the measurement of TAS is more practical .…”

Section: Discussionmentioning

confidence: 99%

What is the Diagnostic Value of Plasma Antioxidative/Oxidative Status in Parapneumonic Effusions in Children?

Aydinoğlu¹,

Cevik²,

Böleken³

et al. 2017

Turkiye Klinikleri J Med Sci

View full text Add to dashboard Cite

A AB BS ST TR RA AC CT T O Ob bj je ec ci iv ve e: : Pleural effusions are associated with high morbidity in children. Oxidative stress, which refers to an imbalance between oxidants and antioxidants, is associated with various diseases including lung diseases. The aim of this study was to investigate to the total oxidative status (TOS) and total antioxidative status (TAS) in differentiating exudates from transudates in children. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In this cross-sectional study, data from patients who were hospitalized for parapneumonic effusions and underwent thoracentesis from October 2012 to December 2013 in the pediatric surgery department. The patiens were divided into two groups (the exuda and transude groups) according to Light's criteria. Blood plasma and parapneumonic effusions were analyzed and compared with respect to the total antioxidative and oxidative status. R Re es su ul lt ts s: : The study consisted of blood plasma and pleural effusion from 40 children with parapneumonic effusions (PPEs) (transude group [n=20]; exuda group [n=20]) and just blood plasma from 30 healthy children (control group). There were no significant difference between the groups in terms of gender and age. The blood plasma TAS level of the control group was significantly higher than the level of blood plasma TAS level of the exuda and transude groups with statistically significant (p<0.001). The value of plasma oxidative stress index (OSI) and TOS of exuda group were significantly higher than those of the control and transude groups with statistically significant (p<0.05). C Co on nc cl lu us si io on n: : This study suggests that inflammation is associated with PPE in children that increased OSI in blood plasma from PPE patients is related to tissue damage and turnover. K Ke ey yw wo or rd ds s: : Child; exudates and transudates Ö ÖZ ZE ET T A Am ma aç ç: : Plevral efüzyonlar çocuklarda yüksek morbidite ile ilişkilidir. Oksidatif stres, oksidanlar ile antioksidanlar arasındaki dengesizliği ifade eder ve akciğer hastalıkları dahil biçok hastalıkla ilişkilidir. Bu çalışmanın amacı, çocuklarda transüda ve eksüdaların ayırıcı tanısında toplam oksidatif durumun (TOS) ve total antioksidatif durumun (TAS) yararlılığını araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu çalışmada kesitsel olarak Ekim 2012'den Aralık 2013'e kadar parapnömonik efüzyon nedeniyle çocuk cerrahisi bölümüne başvuran ve torasentez yapılan hastalardan elde edilen veriler sunulmuştur. Light kriterlerine göre hastalar iki gruba ayrıldı (eksudatif ve transudatif). Kan plazması ve parapnömonik efüzyonlar analiz edilip ve toplam antioksidatif ve oksidatif duruma göre karşılaştırıldı. B Bu ul lg gu ul la ar r: : Bu çalışma, 30 sağlıklı çocuğun (kontrol grubu) kan plazmasını, 40 parapnömonik efüzyonlu (PPE) hastanın; (transüda grubu [n=20], eksüda grubu [n=20]) kan plazmasını ve pleural efüzyonu içermektedir. Cinsiyet ve yaş açısından gruplar arasında anlamlı fark yoktu. Kontrol grubunun kan plazma TAS...

show abstract

Oxidative stress and enzymic–non-enzymic antioxidant responses in children with acute pneumonia

Cited by 47 publications

References 25 publications

Avaliação de parâmetros antioxidantes em ratos tratados com sevoflurano

Avaliação de parâmetros antioxidantes em ratos tratados com sevoflurano

Relationship between severity of adult community-acquired pneumonia and impairment of the antioxidant defense system

What is the Diagnostic Value of Plasma Antioxidative/Oxidative Status in Parapneumonic Effusions in Children?

Contact Info

Product

Resources

About