Oxidative Stress and Disease

Araújo, Rosângela Ferreira Frade de; Martins, Danyelly Bruneska Gondim; Borba, MariaAmélia C.S.M.

doi:10.5772/65366

Cited by 31 publications

(21 citation statements)

References 41 publications

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“…An excess of reactive oxygen species (ROS) produced at the endogenous level by the mitochondria, by cytochrome P450, and by inflammatory cells, or exogenously generated by ionizing radiations, causes damage to DNA, proteins, and lipids [73]. This process is called oxidative stress and is involved in various diseases including obesity, atherosclerosis, neurological diseases, and cancer [74]. The antioxidant capacity of micronized ZC is based on its ability to avail metal ions present within its structure as cofactors for the activation of antioxidant enzymes.…”

Section: Zeolite Clinoptilolite: a Multifaceted Rockmentioning

confidence: 99%

Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral

et al. 2019

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Zeolites are porous minerals with high absorbency and ion-exchange capacity. Their molecular structure is a dense network of AlO4 and SiO4 that generates cavities where water and other polar molecules or ions are inserted/exchanged. Even though there are several synthetic or natural occurring species of zeolites, the most widespread and studied is the naturally occurring zeolite clinoptilolite (ZC). ZC is an excellent detoxifying, antioxidant and anti-inflammatory agent. As a result, it is been used in many industrial applications ranging from environmental remediation to oral applications/supplementation in vivo in humans as food supplements or medical devices. Moreover, the modification as micronization of ZC (M-ZC) or tribomechanically activated zeolite clinoptilolite (TMAZ) or furthermore as double tribomechanically activated zeolite clinoptilolite (PMA-ZC) allows improving its benefits in preclinical and clinical models. Despite its extensive use, many underlying action mechanisms of ZC in its natural or modified forms are still unclear, especially in humans. The main aim of this review is to shed light on the geochemical aspects and therapeutic potentials of ZC with a vision of endorsing further preclinical and clinical research on zeolites, in specific on the ZC and its modified forms as a potential agent for promoting human brain health and overall well-being.

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Section: Zeolite Clinoptilolite: a Multifaceted Rockmentioning

confidence: 99%

Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral

et al. 2019

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“…The hydroxyl radical and peroxynitrite are the major endogenous oxidants that cause damage to the nucleic acids, including nucleotide bases modifications, apurinic and apyrimidinic sites training, and single or double strand breaking. Furthermore, guanine is the most susceptible nucleotide base due to its lower reduction potential that results in the interactions with the imidazole ring at positions C4, C5, and C8 [58]. Nevertheless, ROS and RNS can lead to excessive lipid peroxidation, which is a highly cell damaging process.…”

Section: Oxidative Stress Mechanismsmentioning

confidence: 99%

Antioxidant Therapies for Neuroprotection—A Review

Teleanu

Chircov

Grumezescu

et al. 2019

JCM

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Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the ability of the body to neutralize and eliminate them. In the brain, oxidative stress exhibits significant effects, due to its increased metabolical activity and limited cellular regeneration. Thus, oxidative stress is a major factor in the progressive loss of neurons structures and functions, leading to the development of severe neurodegenerative disorders. In this context, recent years have witnessed tremendous advancements in the field of antioxidant therapies, with a special emphasis for neuroprotection. The aim of this paper is to provide an overview of the oxidative stress and antioxidant defense mechanisms and to present the most recent studies on antioxidant therapies for neuroprotection.

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“…Increased ROS production promotes redox imbalance with the consequent oxidation of biomolecules, such as lipid, protein and nucleic acids, which in turn determine loss of their cellular functions [33]. Thus, OS can lead to altered membrane permeability, disrupted enzymatic activity and DNA lesions, among others [33]. Here, we analyzed the redox status of two skeletal muscles, quadriceps and gastrocnemius, in dysferlin-deficient Bla/J mice, a dysferlinopathy animal model.…”

Section: Nac Restores the Redox Balance In Dysferlin-deficient Skeletmentioning

confidence: 99%

N-Acetylcysteine Reduces Skeletal Muscles Oxidative Stress and Improves Grip Strength in Dysferlin-Deficient Bla/J Mice

García-Campos

Báez‐Matus

Paz-Araos

et al. 2020

IJMS

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Dysferlinopathy is an autosomal recessive muscular dystrophy resulting from mutations in the dysferlin gene. Absence of dysferlin in the sarcolemma and progressive muscle wasting are hallmarks of this disease. Signs of oxidative stress have been observed in skeletal muscles of dysferlinopathy patients, as well as in dysferlin-deficient mice. However, the contribution of the redox imbalance to this pathology and the efficacy of antioxidant therapy remain unclear. Here, we evaluated the effect of 10 weeks diet supplementation with the antioxidant agent N-acetylcysteine (NAC, 1%) on measurements of oxidative damage, antioxidant enzymes, grip strength and body mass in 6 months-old dysferlin-deficient Bla/J mice and wild-type (WT) C57 BL/6 mice. We found that quadriceps and gastrocnemius muscles of Bla/J mice exhibit high levels of lipid peroxidation, protein carbonyls and superoxide dismutase and catalase activities, which were significantly reduced by NAC supplementation. By using the Kondziela’s inverted screen test, we further demonstrated that NAC improved grip strength in dysferlin deficient animals, as compared with non-treated Bla/J mice, without affecting body mass. Together, these results indicate that this antioxidant agent improves skeletal muscle oxidative balance, as well as muscle strength and/or resistance to fatigue in dysferlin-deficient animals.

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Oxidative Stress and Disease

Cited by 31 publications

References 41 publications

Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral

Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral

Antioxidant Therapies for Neuroprotection—A Review

N-Acetylcysteine Reduces Skeletal Muscles Oxidative Stress and Improves Grip Strength in Dysferlin-Deficient Bla/J Mice

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