Oxidative stress and deregulations in base excision repair pathway as contributors to gallbladder anomalies and carcinoma – a study involving North-East Indian population

Singh, Nidhi; Kazim, Syed Naqui; Sultana, Rizwana; Tiwari, Diptika; Borkotoky, Raktim; Kakati, Shantipriya; Das, Nrityendra Nath; Saikia, Anup; Bose, Sujoy

doi:10.1080/10715762.2019.1606423

Cited by 3 publications

(1 citation statement)

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“…Risk factors of GBC may vary depending on geographical and environmental variations (Zhou et al , 2016). Several risk factors such as chronic inflammation, exposure to chemicals and nutrients can cause increased production of reactive oxygen species resulting in oxidative damage to gallbladder cells (Srivastava et al , 2009; Singh et al , 2019). DNA repair mechanisms maintain genomic stability and integrity.…”

Section: Introductionmentioning

confidence: 99%

PARP1 rs1136410 (A/G) polymorphism is associated with early age of onset of gallbladder cancer

Anjali

Singh

Kumar

et al. 2021

European Journal of Cancer Prevention

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Objectives Evaluation of the association of PARP1 rs1136410 (A/G) polymorphism with gallbladder cancer susceptibility and its prognosis in the Indian population of eastern Uttar Pradesh and western Bihar. Methods PARP1 rs1136410 was genotyped by PCR-RFLP and its association with the prognosis of gallbladder cancer patients were analyzed using Kaplan–Meier plot and log-rank tests. Results Our results demonstrate that minor allele G is more frequent in gallbladder cancer patients than controls. The frequencies of minor allele G and GG genotype are significantly associated with increased risk of gallbladder cancer. Our data suggest that the minor allele G and homozygous genotype GG are significant predisposing factors for the early age of onset of gallbladder cancer. Similarly, women patients having AG and GG genotypes demonstrate an increased risk of gallbladder cancer. The risk group genotypes (AG + GG) are significantly more frequent in patients with thick gallbladder wall, with jaundice and with the presence of lymph node than in patients with normal gallbladder wall thickness, without jaundice and absence of lymph node involvement. Survival analysis data suggest that patients with risk group genotype (AG + GG) presenting jaundice have shorter overall survival. Conclusion Our study suggests that the minor allele G of PARP1 rs1136410 (A/G) is a predisposing factor for gallbladder carcinogenesis and is significantly associated with early onset of the disease. Interestingly, the minor allele G is significantly more frequent in the patients with jaundice, lymph node metastasis and gallbladder wall thickness.

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Section: Introductionmentioning

confidence: 99%

PARP1 rs1136410 (A/G) polymorphism is associated with early age of onset of gallbladder cancer

Anjali

Singh

Kumar

et al. 2021

European Journal of Cancer Prevention

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Association of haplotype and linkage disequilibrium of PARP1 polymorphisms rs1136410, rs1805405 and rs3219088 with gallbladder cancer

Anjali¹,

Kumar²,

Kar³

et al. 2023

Digestive and Liver Disease

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Gallbladder cancer: Progress in the Indian subcontinent

Kumar,

Sarangi,

Gupta

et al. 2024

World J Clin Oncol

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Gallbladder cancer (GBC) is one of the commonest biliary malignancies seen in India, Argentina, and Japan. The disease has dismal outcome as it is detected quite late due to nonspecific symptoms and signs. Early detection is the only way to improve the outcome. There have been several advances in basic as well as clinical research in the hepatobiliary and pancreatic diseases in the West and other developed countries but not enough has been done in GBC. Therefore, it is important and the responsibility of the countries with high burden of GBC to find solutions to the many unanswered questions like etiopathogenesis, early diagnosis, treatment, and prognostication. As India being one of the largest hubs for GBC in the world, it is important to know how the country has progressed on GBC. In this review, we will discuss the outcome of the publications from India highlighting the work and the developments taken place in past several decades both in basic and clinical research.

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Oxidative stress and deregulations in base excision repair pathway as contributors to gallbladder anomalies and carcinoma – a study involving North-East Indian population

Cited by 3 publications

References 50 publications

PARP1 rs1136410 (A/G) polymorphism is associated with early age of onset of gallbladder cancer

PARP1 rs1136410 (A/G) polymorphism is associated with early age of onset of gallbladder cancer

Association of haplotype and linkage disequilibrium of PARP1 polymorphisms rs1136410, rs1805405 and rs3219088 with gallbladder cancer

Gallbladder cancer: Progress in the Indian subcontinent

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