Oxidative stress and cyclooxygenase activity in prostate carcinogenesis: targets for chemopreventive strategies

Pathak, S.; Sharma, Ricky A.; Steward, W.P.; Mellon, J. Kilian; Griffiths, T.R. Leyshon; Gescher, Andreas

doi:10.1016/j.ejca.2004.09.028

Cited by 116 publications

(87 citation statements)

References 87 publications

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“…S3C, D). Besides superoxide, COX-2 also produces prostaglandins (34). We observed that in PC3 cells, after block of COX-2 with nimesulide, the administration of prostaglandin E2 (PGE 2 ) does not imitate CAF exposure.…”

mentioning

confidence: 77%

“…COX-2 is dramatically known as a conspirator of prostate cancer progression, although its specific role is uncertain. Early observations indicated a correlation with expression of COX-2 and prostate tumor grade (19,23,34). In addition, COX-2 has also found increased in high-grade prostate intraepithelial neoplasia in the TRAMP mouse model (37).…”

Section: Discussionmentioning

confidence: 99%

“…CAF-mediated ROS production in PC3 cells is mandatory for EMT and stemness COX-2-mediated ROS mainly affects the pre-malignant condition and carcinogenesis of high-grade prostate intraepithelial neoplasia, but its role in tumor progression is unknown (34). We, therefore, analyzed the role of ROS produced on CAF exposure, mainly due to COX-2 activation, in EMT and invasiveness.…”

Section: Pca Cells Activate Reactive Oxygen Species Production On Cafmentioning

confidence: 99%

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Cancer Associated Fibroblasts Exploit Reactive Oxygen Species Through a Proinflammatory Signature Leading to Epithelial Mesenchymal Transition and Stemness

Giannoni

Bianchini

Calorini

et al. 2011

Antioxidants & Redox Signaling

188

170

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Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial mesenchymal transition (EMT) of tumor cells and their achievement of stem cell traits. We demonstrate that CAFs induce EMT and stemness through a proinflammatory signature, which exploits reactive oxygen species to drive a migratory and aggressive phenotype of prostate carcinoma cells. CAFs exert their propelling role for EMT in strict dependence on cycloxygenase-2 (COX-2), nuclear factor-jB, and hypoxia-inducible factor-1. CAF-secreted metalloproteases elicit in carcinoma cells a Rac1b/COX-2-mediated release of reactive oxygen species, which is mandatory for EMT, stemness, and dissemination of metastatic cells. Tumor growth is abolished, and metastasis formation is severely impaired by RNA interfering-mediated targeting of the proinflammatory signature, thereby supporting the therapeutic targeting of the circuitry COX-2/nuclear factor-jB /hypoxia-inducible factor-1 as a valuable antimetastatic tool affecting cancer cell malignancy.

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mentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Pca Cells Activate Reactive Oxygen Species Production On Cafmentioning

confidence: 99%

See 1 more Smart Citation

Cancer Associated Fibroblasts Exploit Reactive Oxygen Species Through a Proinflammatory Signature Leading to Epithelial Mesenchymal Transition and Stemness

Giannoni

Bianchini

Calorini

et al. 2011

Antioxidants & Redox Signaling

188

170

View full text Add to dashboard Cite

show abstract

“…Molecular crosstalk between the primary tumor and the pre-metastasis niche through secreted stimulatory signals helps govern the homing of mCSCs. Trafficking towards preferred tissues and organs of mCSCs is guided by cues such as oxygen gradients or other chemo-attractants derived from niche sites [94,[123][124][125].…”

Section: Cscs and Metastasismentioning

confidence: 99%

Beyond tumorigenesis: cancer stem cells in metastasis

et al. 2006

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“…Oxidative stress levels in PC3 and LNCaP cell lines A series of epidemiologic studies and laboratory observations suggest that oxidative stress may be linked to the effects of androgen, antioxidant system, the pre-malignant condition, and high-grade prostatic intraepithelial neoplasia (Pathak et al, 2005). Prostate cancer cells produce substantial amounts of ROS, in part from stimulation of a nonphagocytic Ca 2+ -regulated NADPH oxidase (Sauer et al, 2001;Lim et al, 2005).…”

Section: Properties Of Pc3 and Lncap Cell Linesmentioning

confidence: 99%

Up-regulation of defense enzymes is responsible for low reactive oxygen species in malignant prostate cancer cells

Lim

Hong²,

Jin³

et al. 2005

Exp Mol Med

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Oxidative stress and cyclooxygenase activity in prostate carcinogenesis: targets for chemopreventive strategies

Cited by 116 publications

References 87 publications

Cancer Associated Fibroblasts Exploit Reactive Oxygen Species Through a Proinflammatory Signature Leading to Epithelial Mesenchymal Transition and Stemness

Cancer Associated Fibroblasts Exploit Reactive Oxygen Species Through a Proinflammatory Signature Leading to Epithelial Mesenchymal Transition and Stemness

Beyond tumorigenesis: cancer stem cells in metastasis

Up-regulation of defense enzymes is responsible for low reactive oxygen species in malignant prostate cancer cells

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