Oxidative Stress and Cardiovascular Risk and Prevention in Children and Adolescents

Mastorci, Francesca; Traghella, Irene; Sabatino, Laura; Pingitore, Alessandro; Ndreu, Rudina; Vassalle, Cristina

doi:10.1007/978-981-13-8273-4_1

Cited by 2 publications

(2 citation statements)

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“…Among these, lipid peroxidation biomarkers (e.g., isoprostanes [IsoP] and malondialdehyde [MDA]) are the most used and have attracted great interest, not only for studying physiopathological mechanisms but also for possible implementation in routine clinical laboratory use [2]. Moreover, antioxidant biomarkers can also be evaluated assessing the total antioxidant capacity (TAC); enzymatic antioxidants, such as catalase, glutathione peroxidase, superoxide dismutase; or nonenzymatic markers like vitamins, glutathione and uric acid [2,3]. In view of all the evidence available in experimental studies and clinical trials, the role of oxidative stress in the onset and progression of atherosclerosis and cardiovascular disease is now widely confirmed [4].…”

Section: Introductionmentioning

confidence: 99%

Conventional and Innovative Methods to Assess Oxidative Stress Biomarkers in the Clinical Cardiovascular Setting

2020

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Oxidative stress has a pivotal and widely described role in the onset and progression of atherosclerotic plaque and cardiovascular disease. Many oxidative stress-related biomarkers can be measured in biological samples; however, there are still many aspects that limit the adoption of oxidative stress assessment in clinical laboratory practice. Here, we report an overview of the different sources and main common oxidative stress biomarkers relevant for cardiovascular physiopathology, describing in detail a recently proposed lipidomic assay for ceramide assessment, as a promising future development in oxidative stress evaluation among the many available redox-related tests.

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Section: Introductionmentioning

confidence: 99%

Conventional and Innovative Methods to Assess Oxidative Stress Biomarkers in the Clinical Cardiovascular Setting

2020

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“…Children and adolescents seem to be more susceptible to exposure to accumulated reactive oxygen species and carcinogenic factors during development stages (4)(5)(6)(7) . Moreover, unhealthy risk factors in children and adolescents could contribute to the long-term influence on non-communicable diseases in adult life based on the developmental origins of health and disease hypothesis (8) .…”

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Higher ultra-processed food intake is associated with higher DNA damage in healthy adolescents

et al. 2020

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Ultra-processed food is one of the main contributors to energy supply and consumption in food systems worldwide, and evidence of their detrimental health outcomes in humans is emerging. This study aimed to assess ultra-processed food intake and its association with urinary levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of DNA oxidative damage, in 139 healthy adolescents in Karaj city in Iran. Usual dietary intake was measured using a 168-item validated food frequency questionnaire. The daily intake of ultra-processed food consumption was determined through the classification of NOVA and general linear models were used to compare the urinary levels of 8-OHdG/creatinine (ng/mg crn) within tertiles of ultra-processed food intake. Adolescents in the higher tertile of ultra-processed food consumption had a significantly higher mean level of urinary 8-OHdG/ creatinine in comparison to the lower tertiles in the crude model (P for trend: 0.003) and after adjustment for confounding variables, including total energy intake, sex, age, body mass index (BMI) for age Z-score, obesity, and physical activity (P for trend:0.004). This association was still significant after adjusting for dietary intake of whole grains, nuts, legumes, the ratio of monosaturated fatty acids (MUFAs) to saturated fatty acids (SFAs) (g/day), and Mediterranean dietary score (P for trend: 0.002). More studies are needed to explore the determinants of ultra-processed food supply, demand, consumption, and health effects; such studies should be applied to develop evidence-informed policies and regulatory mechanisms to improve children’s and adolescents’ food environment policy-making and legislation with special attention to ultra-processed food.

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Oxidative Stress and Cardiovascular Risk and Prevention in Children and Adolescents

Cited by 2 publications

References 69 publications

Conventional and Innovative Methods to Assess Oxidative Stress Biomarkers in the Clinical Cardiovascular Setting

Conventional and Innovative Methods to Assess Oxidative Stress Biomarkers in the Clinical Cardiovascular Setting

Higher ultra-processed food intake is associated with higher DNA damage in healthy adolescents

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