Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10)

Donaldson, Ken; Stone, Vicki; Borm, Paul J. A.; Jiménez, Luis A.; Gilmour, Peter S.; Schins, Roel P. F.; Knaapen, Ad M.; Rahman, Irfan; Faux, Stephen P.; Brown, David M.; MacNee, William

doi:10.1016/s0891-5849(03)00150-3

Cited by 389 publications

(265 citation statements)

References 121 publications

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“…We also examined the health implications of the 2S scooter SOA (other than those from the mass increase) using online measurements of particle-bound, water soluble reactive oxygen species (ROS) 16 , which are linked to negative health effects 17 . ROS are undetectable in POA, but accounts for 0.5-1% carbon in the aged OA, suggesting that PM emissions initially become increasingly toxic with aging ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Two-stroke scooters are a dominant source of air pollution in many cities

et al. 2014

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Fossil fuel-powered vehicles emit significant particulate matter, for example, black carbon and primary organic aerosol, and produce secondary organic aerosol. Here we quantify secondary organic aerosol production from two-stroke scooters. Cars and trucks, particularly diesel vehicles, are thought to be the main vehicular pollution sources. This needs re-thinking, as we show that elevated particulate matter levels can be a consequence of 'asymmetric pollution' from two-stroke scooters, vehicles that constitute a small fraction of the fleet, but can dominate urban vehicular pollution through organic aerosol and aromatic emission factors up to thousands of times higher than from other vehicle classes. Further, we demonstrate that oxidation processes producing secondary organic aerosol from vehicle exhaust also form potentially toxic 'reactive oxygen species'.

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Section: Resultsmentioning

confidence: 99%

Two-stroke scooters are a dominant source of air pollution in many cities

et al. 2014

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“…The strength of this approach is that it circumvents effects related to the pulmonary accumulation of particles, eg, release of inflammatory mediators from the lung parenchyma. The estimated total number of particles infused was either 1ϫ10 7 or 5ϫ10 7 . According to experimental and epidemiological data, this range roughly characterizes the daily amount of UFPs translocated from the lungs into the blood in mice during inhalation studies 11,16 or in humans exposed to prevailing UFP concentrations in urban air.…”

Section: Ultrafine Particlesmentioning

confidence: 99%

“…1 Moreover, air pollution episodes were associated with an increased heart rate, 4 decreased heart rate variability, 5 and elevated risk of implanted cardioverter-defibrillator discharges. 2 Although the exact mechanism by which airborne particles exert adverse effects is unknown, ambient particles are thought to enhance pulmonary inflammation associated with systemic hypercoagulability, generation of oxidants, activation of complement, increase in blood viscosity, and elevation of fibrinogen and C-reactive protein plasma concentration (reviewed by Donaldson et al 6,7 ).…”

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confidence: 99%

Ultrafine Particles Exert Prothrombotic but Not Inflammatory Effects on the Hepatic Microcirculation in Healthy Mice In Vivo

Khandoga¹,

Stampfl²,

Takenaka³

et al. 2004

Circulation

120

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Background-Air pollution episodes are strongly associated with increased cardiovascular morbidity and mortality. The effect of ultrafine particles (UFPs), when translocated after inhalation, on the microcirculation of extrapulmonary organs remains unclear. Methods and Results-In C57BL/6 mice, either carbon black UFPs (1ϫ10 7 and 5ϫ10 7 ) or vehicle was infused intra-arterially. Two hours after infusion, platelet-and leukocyte-endothelial cell interactions, sinusoidal perfusion, endothelial fibrin(ogen) deposition, and phagocytic activity of Kupffer cells were analyzed by intravital video fluorescence microscopy in the liver microvasculature. Expression of fibrin(ogen), von Willebrand factor (vWF), and P-selectin on hepatic endothelium was determined by immunostaining. Apoptotic cells were quantified in TUNELstained tissue sections. Application of UFPs caused significantly enhanced platelet accumulation on endothelium of postsinusoidal venules and sinusoids in healthy mice. UFP-induced platelet adhesion was not preceded by platelet rolling but was strongly associated with fibrin deposition and an increase in vWF expression on the endothelial surface. In contrast, inflammatory parameters such as the number of rolling/adherent leukocytes, P-selectin expression/ translocation, and the number of apoptotic cells were not elevated 2 hours after UFP exposure. In addition, UFPs did not affect sinusoidal perfusion and Kupffer cell function. Conclusions-UFPs

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“…Fe) (Carter et al 1997 ;Hutchison et al 2005 ;Roig et al 2013 ';Schins et al 2004 ), organics (i.e. polycyclic aromatic hydrocarbons or PAHs) (Billet et al 2008 ) and endotoxins (Becker et al 2003 ;Longhin et al 2013 ;Oberdorster et al 2000 ; in the PM seem to be involved in this process (Donaldson et al 2003 ;Schwarze et al 2006 ;Sorensen et al 2003 ). Moreover, although secondary inorganic aerosols show less toxic activity when tested under controlled laboratory conditions, epidemiological studies demonstrate significant associations between sulphates and nitrates and various health outcomes.…”

Section: Introductionmentioning

confidence: 99%