Oxidative stress and apoptosis in preeclampsia

Çan, Murat; Güven, Berrak; Bektaş, Sibel; Arıkan, İlker

doi:10.1016/j.tice.2014.08.004

Cited by 51 publications

(41 citation statements)

References 26 publications

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“…In our case, it is manifested in high efficiency of energy production. Indeed, it is well known that oxidative stress appears in the PE placenta11142829. The high P/O ratio and ROS production seem to be positively coregulated2730.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial role in adaptive response to stress conditions in preeclampsia

Vishnyakova

Володина

Тарасова

et al. 2016

Sci Rep

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Preeclampsia (PE) is a pregnancy-specific syndrome, characterized in general by hypertension with proteinuria or other systemic disturbances. PE is the major cause of maternal and fetal morbidity and mortality worldwide. However, the etiology of PE still remains unclear. Our study involved 38 patients: 14 with uncomplicated pregnancy; 13 with early-onset PE (eoPE); and 11 with late-onset PE (loPE). We characterized the immunophenotype of cells isolated from the placenta and all biopsy samples were stained positive for Cytokeratin 7, SOX2, Nestin, Vimentin, and CD44. We obtained a significant increase in OPA1 mRNA and protein expression in the eoPE placentas. Moreover, TFAM expression was down-regulated in comparison to the control (p < 0.01). Mitochondrial DNA copy number in eoPE placentas was significantly higher than in samples from normal pregnancies. We observed an increase of maximum coupled state 3 respiration rate in mitochondria isolated from the placenta in the presence of complex I substrates in the eoPE group and an increase of P/O ratio, citrate synthase activity and decrease of Ca2+-induced depolarization rate in both PE groups. Our results suggest an essential role of mitochondrial activity changes in an adaptive response to the development of PE.

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Section: Discussionmentioning

confidence: 99%

Mitochondrial role in adaptive response to stress conditions in preeclampsia

Vishnyakova

Володина

Тарасова

et al. 2016

Sci Rep

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“…This increase has been associated with various diseases such as cancer, atherosclerosis and preeclampsia (PE), among others (33)(34)(35). Imbalance between antioxidant defenses and lipid peroxidation leads to endothelial dysfunction and cell damage mediated by free radicals, altering trophoblast differentiation processes and migration to the uterine spiral arteries, and causing poor placentation and, consequently, pregnancy hypertensive disease (5,36,37). In pregnant women with preeclampsia, high levels of oxidative stress and low antioxidant status were found (38).…”

Section: Discussionmentioning

confidence: 99%

Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease

et al. 2017

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Background: Previously has been reported the antioxidant function of iodine, and iodine deficiency as a risk factor of preeclampsia.Aim: We analyze the association between iodine deficiency, oxidative stress and antioxidant status with hypertensive disease of pregnancy (HPD).Method: 57 pregnant women were recruited in the last trimester of pregnancy, 20 diagnosed with hypertensive disease of pregnancy and 37 normotensive pregnant women. Urinary iodine concentration (UIC), TSH, free T4 (fT4), total antioxidant status (FRP), Superoxide dismutase (SOD), Catalase (CAT), and oxidative stress (TBARS) were evaluated by colorimetric methods.Results: UIC median for all pregnant women was of 151.9 µg / L. The UIC median for pregnant women with HPD was between 50-149 µg/L compared to 150-249 µg/L in normotensive women. No significant changes were found in levels of TSH and fT4 in normotensive pregnant compared with HPD women. Pregnant women with HPD had significant high levels of TBARS, and significant low levels of FRP, SOD, CAT and UIC compared to normotensive pregnant. In addition, pregnant women with optimal levels of UIC had a higher SOD activity (R = 0.354, P = 0.011), while iodine deficiency was associated with HPD (R = -0,281, p = 0.039). Similarly, pregnant with HPD had a significant negative association with SOD activity (R = -0,702, p = 0.005), CAT (R = -0,409, p = 0.002), and FRP (R = -0,624, p = 0.003), and a positive association with TBARS (R = 0.744, p = 0.001).Conclusion: iodine contributes to REDOX balance during pregnancy; its deficiency is associated with HPD. This study shows the importance of iodine during pregnancy.

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“…In our earlier study, we have reported higher oxidative stress indicated by the increased MDA levels in all regions of preterm preeclampsia group as compared to the normotensive control group [24]. Studies from our department and by others suggest that there is a presence of higher oxidative stress in women with preeclampsia and in preeclampsia placenta [29,30]. Oxidative stress has been shown to be higher in case of preterm preeclampsia [31].…”

Section: Discussionmentioning

confidence: 53%