Oxidative Stress and Antioxidative Status of Plasma and Erythrocytes in Patients with Vivax Malaria

Erel, Özcan; Koçyiğit, Abdürrahim; Avci, Senel; Aktepe, N; Bulut, Vedat

doi:10.1016/s0009-9120(97)00119-7

Cited by 83 publications

(44 citation statements)

References 62 publications

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“…As thermal stress caused by high temperatures is likely to decrease with latitude, and cysteine-GSH promotes pheomelanogenesis and inhibits eumelanogenesis [3], conditions favoring the production of pheomelanin may prevail at high latitudes, as is indeed observed [15]. A higher prevalence of human parasites at low latitudes [29] may also contribute to this, as parasites generate oxidative stress in their hosts [30]. Indeed, it has been suggested that high levels of human skin eumelanization have evolved as a response to high parasite abundance and diversity in the tropics [31].…”

Section: Implications For Understanding Human Pigmentation Patternsmentioning

confidence: 88%

Has removal of excess cysteine led to the evolution of pheomelanin?

2012

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Section: Implications For Understanding Human Pigmentation Patternsmentioning

confidence: 88%

Has removal of excess cysteine led to the evolution of pheomelanin?

2012

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“…13,16 Serum malondialdehyde (MDA) levels were measured using a fluorimetric method. 17,18 Lipid hydroperoxide serum concentrations were also measured using the automated ferric-xylenol orange method. 19 The TOS to TAC ratio was regarded as the oxidative stress index (OSI).…”

Section: Methodsmentioning

confidence: 99%

Estado oxidante/antioxidante total em recém-nascidos ictéricos antes e depois da fototerapia

Ayçicek¹,

Erel²

2007

J. Pediatr. (Rio J.)

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Objective: To assess the effect of phototherapy on serum oxidant and antioxidant status in hyperbilirubinemic full-term newborns.Method: Thirty-four full-term infants from 3 to 10 days of age exposed to phototherapy were studied. The serum antioxidant status was assessed by measuring the total antioxidant capacity (TAC) and individual antioxidant components: vitamin C, uric acid, albumin, thiol contents and total bilirubin. The oxidant status was assessed by determining the total oxidant status (TOS), oxidative stress index (OSI) and individual oxidant components: malondialdehyde (MDA), and lipid hydroperoxide levels.Results: Vitamin C, uric acid, total bilirubin and MDA concentration were significantly lower, whereas serum TOS, lipid hydroperoxide and OSI levels were significantly higher after phototherapy (p < 0.05). There were significant positive correlations between serum total bilirubin and MDA (r = 0.434, p = 0.001). Conclusions:Although the MDA level was reduced after phototherapy, phototherapy has a negative impact on numerous parts of the oxidant/antioxidant defense system in jaundiced full-term newborns, exposing them to potential oxidative stress.J Pediatr (Rio J). 2007;83(4):319-322: Antioxidants, infant, malondialdehyde, oxidative stress, phototherapy.

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“…Implicated agents include phenacetin, lignocaine, notably nitrate and nitrite containing compounds [2][3][4][5]. It has also been documented in P. vivax malaria patients associated with high doses of primaquin treatment [6,7]. In malaria infections, modification of haemoglobin molecules lead to acquired methaemoglobinemia.…”

Section: Introductionmentioning

confidence: 99%

Study of Methaemoglobin in Malaria Patients

Behera

Jena

et al. 2015

Indian J Hematol Blood Transfus

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To estimate the concentration of methemoglobin (MetHb) in malaria patients and correlate with severity of malaria infection. This prospective study included 30 untreated cases of malaria confirmed by Quantitative Buffy Coat (QBC) test and 30 age sex matched non-malarial cases taken as controls. All the patients underwent thorough clinical examination and routine biochemical investigation. Methemoglobin levels were estimated by spectrophotometric (co-oxymeter) method on day 1 and day 10 of diagnosis of all study group patients and correlated with clinical profile and severity. Out of 30 malaria patients 22 were males and eight were females. The clinical presentations in complicated malaria group (n = 21) were fever 21 (100 %), anemia 17 (80.95 %), renal failure 12 (52.38 %) and coma/convulsion 5 (23.8 %). The mean age of the study group was 41.66 years. Mean MetHb in complicated malaria on day 1 was 2.55 ± 1.75 % and day 10 was 10.69 ± 8.19 % (statistically significant). The overall mortality was 13 (43.33 %) among study group while 5 (16.66 %) was found among control group. Mean MetHb who died (n = 13) on day 1 was 3.144 ± 1.829 % and (n = 8) on day 10 it was 19.982 ± 8.406 %. Increase in level of methaemoglobin is detrimental to the body and is associated with increase in mortality. Routine MetHb estimation may be used as a prognostic indicator in the management of malaria patients. It is suggested that addition of drugs which reduce MetHb may be tried along with antimalarial drugs to decrease morbidity and mortality in malaria.

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Oxidative Stress and Antioxidative Status of Plasma and Erythrocytes in Patients with Vivax Malaria

Cited by 83 publications

References 62 publications

Has removal of excess cysteine led to the evolution of pheomelanin?

Has removal of excess cysteine led to the evolution of pheomelanin?

Estado oxidante/antioxidante total em recém-nascidos ictéricos antes e depois da fototerapia

Study of Methaemoglobin in Malaria Patients

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