Oxidative Stress and Antioxidants at Biosurfaces: Plants, Skin, and Respiratory Tract Surfaces

Cross, Carroll E.; Vliet, Albert van der; Louie, Sam; Thiele, Jens J.; Halliwell, Barry

doi:10.2307/3433992

Cited by 28 publications

(26 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…When an oxidant gas or particle enters the lung, the first interface it encounters is the lung lining fluid. Human lung lining fluid is a complex and regionally heterogeneous compartment ranging in depth from between 1 and 10 mm in the proximal airways to 0.2 and 0.5 mm in the distal airways and alveoli [5]. Lung lining fluid consists of secretions from underlying lung and resident immune cells, as well as plasma-derived exudates.…”

Section: Pulmonary Antioxidant Defencesmentioning

confidence: 99%

Antioxidants and allergic disease: a case of too little or too much?

Allan

Kelly

Devereux

2010

Clin Experimental Allergy

View full text Add to dashboard Cite

Speculation persists as to the possible role, if any, of dietary antioxidants in allergic disease. While it has been hypothesized that the recent increase in allergic disease is a consequence of declining dietary antioxidant intake, an alternative hypothesis proposes that the increase in allergic disease is due to increasing antioxidant intake. Dietary trends are conflicting; the intake of some antioxidants has declined, for others intakes are likely to have increased. Animal model studies demonstrate that antioxidant supplementation at the time of primary and subsequent allergen exposure attenuates allergic inflammatory responses. The data from human studies are less clear. Observational epidemiological studies of humans are beset by several methodological limitations associated with the assessment of diet and predominantly focus on asthma. Most observational studies report potentially beneficial associations between dietary antioxidants and allergic outcomes, but a small minority report potentially adverse associations. Human intervention studies suggest that single antioxidant supplements confer minimal, if any clinical benefit in adults with asthma, however, there is still scope for studies in children, atopic dermatitis, allergic rhinitis (AR) and of antioxidant combinations. More recently, it has been suggested that dietary antioxidants in the developmental context of fetal and infant development influence the development childhood asthma and atopic sensitization possibly by affecting the first interactions between the neonatal immune system and allergens. While a small number of birth cohort studies have reported potentially beneficial associations between maternal intake of some antioxidants during pregnancy and childhood asthma, there is very limited data suggesting associations between maternal antioxidant intake and childhood atopic dermatitis and AR. The available epidemiological, animal, molecular and immunological data suggest that there are associations between antioxidants and asthma and to a much lesser extent, atopic dermatitis and AR. However, the exact nature of the relationships and the potential for therapeutic intervention remain unclear.

show abstract

Section: Pulmonary Antioxidant Defencesmentioning

confidence: 99%

Antioxidants and allergic disease: a case of too little or too much?

Allan

Kelly

Devereux

2010

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…Various species of active oxygen produced from dioxygen, i.e. superoxide ion, hydroxyl radical and hydrogen peroxide, are deleterious to cellular growth and development of many, if not all, living organisms [5]. Such active oxygen species can disrupt cellular membranes, induce oxidative changes in DNA and disrupt cellular metabolism [6].…”

Section: Introductionmentioning

confidence: 99%

Effects of oligosaccharides and polysaccharides on the generation of reactive oxygen species in different biological systems

Radman

Bland

Sangworachat

et al. 2006

Biotech and App Biochem

View full text Add to dashboard Cite

Use of carbohydrates as elicitors is a novel technique for enhancement of the production of industrially important microbial products. The relation between the levels of ROS (reactive oxygen species) and overproduction of antibiotics in microbial cultures has already been established. In the present study, we aimed to exploit the ROS response to develop a fast technique to assess the potential of oligosaccharides [oligoguluronate, oligomannuronate and MO (mannan oligosaccharides)] and polysaccharides [alginate and LBG (locust-bean gum)] as elicitors for overproduction of secondary metabolites in Streptomyces rimosus and Penicillium chrysogenum. We have also investigated changes in the production of ROS in neutrophils as a result of the action of the same elicitors. LBG-derived oligosaccharides (MO) were most potent inhibitors of ROS in all systems investigated. This correlates with overproduction of secondary metabolites in microbes and enhancement of a number of mammalian systems. We believe that the effects of oligosaccharides and polysaccharides on ROS production by mammalian and microbial cells can be correlated predicatively with overproduction. The underlying methodology offers a fast screening of elicitors that can be applied across the different systems.

show abstract

“…Skin is constantly exposed to pro-oxidant environmental stresses from an array of sources, such as air pollutants, solar UV light, chemical oxidants, micro-organisms, cigarette smoke and ozone (Thiele et al 1997;Cross et al 1998). Reactive oxygen species have been implicated in the aetiology of several skin disorders including skin cancer and photoageing (Perchellet & Perchellet, 1989;Dalle & Pathak, 1992;Emerit, 1992;Guyton & Kensler, 1993).…”

mentioning

confidence: 99%

Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium

et al. 2006

View full text Add to dashboard Cite

Dietary bioactive compounds (vitamin E, carotenoids, polyphenols, vitamin C, Se and Zn) have beneficial effects on skin health. The classical route of administration of active compounds is by topical application direct to the skin, and manufacturers have substantial experience of formulating ingredients in this field. However, the use of functional foods and oral supplements for improving skin condition is increasing. For oral consumption, some dietary components could have an indirect effect on the skin via, for example, secondary messengers. However, in the case of the dietary bioactive compounds considered here, we assume that they must pass down the gastrointestinal tract, cross the intestinal barrier, reach the blood circulation, and then be distributed to the different tissues of the body including the skin. The advantages of this route of administration are that the dietary bioactive compounds are metabolized and then presented to the entire tissue, potentially in an active form. Also, the blood continuously replenishes the skin with these bioactive compounds, which can then be distributed to all skin compartments (i.e. epidermis, dermis, subcutaneous fat and also to sebum). Where known, the distribution and mechanisms of transport of dietary bioactive compounds in skin are presented. Even for compounds that have been studied well in other organs, information on skin is relatively sparse. Gaps in knowledge are identified and suggestions made for future research. The skin is the largest organ in man, consisting of different layers of epidermis and dermis. Its primary physiological function is that of a barrier between the body and the external environment, protecting against mechanical damage, radiation, toxic compounds and micro-organisms. Skin plays a role in the regulation of body temperature and is involved in body water homeostasis.Skin is constantly exposed to pro-oxidant environmental stresses from an array of sources, such as air pollutants, solar UV light, chemical oxidants, micro-organisms, cigarette smoke and ozone (Thiele et al. 1997;Cross et al. 1998). Reactive oxygen species have been implicated in the aetiology of several skin disorders including skin cancer and photoageing (Perchellet & Perchellet, 1989;Dalle & Pathak, 1992;Emerit, 1992;Guyton & Kensler, 1993). These reactive oxygen species are capable of oxidizing lipids, proteins or DNA leading to the formation of oxidized products such as lipid hydroperoxides, protein carbonyls or 8-hydroxyguanosine, respectively (Beehler et al. 1992;Hu & Tappel, 1992;Podda et al. 1998). Reactive oxygen species are generated constantly in skin, and are rapidly neutralized by non-enzymatic and enzymatic antioxidant substances, which prevent their harmful effects and maintain a pro-oxidant-antioxidant balance, resulting in cell and tissue stabilization. If the antioxidant defence is exhausted, cell damage can occur. Known non-enzymatic scavengers of free radicals in human skin are b-carotene, vitamin C and vitamin E, and enzymatic scavengers are Se-depende...

show abstract

Oxidative Stress and Antioxidants at Biosurfaces: Plants, Skin, and Respiratory Tract Surfaces

Cited by 28 publications

References 90 publications

Antioxidants and allergic disease: a case of too little or too much?

Antioxidants and allergic disease: a case of too little or too much?

Effects of oligosaccharides and polysaccharides on the generation of reactive oxygen species in different biological systems

Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium

Contact Info

Product

Resources

About