Oxidative stress and antioxidant status in women with gestational diabetes mellitus diagnosed by IADPSG criteria

Correlation of adipokines and markers of oxidative stress in women with gestational diabetes mellitus and their newborns

“…Adipokine levels appear to be changing in patients with type 2 diabetes mellitus and GDM diagnosed by other criteria such as the American Diabetes Association criterion . Adipose tissues are major sources of reactive oxygen species (ROS), and some markers of oxidative stress such as malondialdehyde (MDA), xanthine oxidase (XO) and 8‐isoprostane (8ISO) have been shown to be higher in women with GDM diagnosed by the IADPSG criterion in our previous study . But the levels of the adipokines in women with GDM diagnosed with the IADPSG criterion have not been studied ever.…”

Higher level of GGT during mid‐pregnancy is associated with increased risk of gestational diabetes mellitus

“…Firstly, oxidative stress and systemic inflammation mediated by GGT might be involved. Oxidative stress has been implicated in insulin resistance and the impairment of insulin secretion from the pancreatic β‐cells . Elevated GGT levels resulted in the production of glutathione (GSH), which has great antioxidant properties .…”

COX2 and NOS3 gene polymorphisms in women with gestational diabetes

“…[11][12][13] Previous studies have also indicated the role of oxidative stress in the development of GDM. 35 Some studies have shown an increased synthesis of reactive oxygen species and other products of enhanced oxidation in women with GDM, suggesting that increased oxidative stress may be involved in the pathogenesis of GDM. The significant role of oxidative stress and altered synthesis of prostaglandins in GDM was confirmed in a study by Li et al 36 who suggested that increased lipid peroxidation and protein oxidative damage play significant roles in GDM pathogenesis and progression.…”