Oxidative Stress and Antioxidant Status during Transition Period in Dairy Cows

Abstract

The study was conducted on 20 Holstein X Sahiwal cross bred dairy cows, with an average milk production of 2,752±113.79 liters in 284±5.75 days during a single lactation, that were divided in to two groups of 10 animals. We investigated the oxidative stress and antioxidant status during the transition period in dairy cows. In this study, plasma level of MDA was considered as an indicator of lipid peroxidation and SOD, catalase, GSH and GSHPx as antioxidants. The lipid peroxidation was significantly (p<0.001) higher in cows during early lactation as compared to the cows in advanced pregnancy. A significant positive correlation (r = +0.831, p<0.01) was determined between MDA and catalase in early lactating cows. In early lactating cows, blood glutathione was significantly lower than in advanced pregnant cows. However, early lactating cows showed non-significant negative correlation for all antioxidant enzymes with lipid peroxidation. In conclusion, dairy cows seemed to have more oxidative stress and low antioxidant defense during early lactation or just after parturition than advanced pregnant cows, and this appears to be the reason for their increased susceptibility to production diseases (e.g. mastitis, metritis, retention of fetal membranes etc.) and other health problems.

Supplemental Selenium Reduces the Levels of Biomarkers of Oxidative and General Stress in Peripartum Dairy Cows / Dodati Selen Snižava Nivoe Biomarkera Oksidativnog I Opšteg Stresa Kod Mlečnih Krava U Peripartalnom Periodu

“…In partial contrast to our fi nding Sharma et al [30] reported the existence of a negative correlation of GPx with lipid peroxidation in cows in late pregnancy, but not in early lactation. However, plasma GPx in their experiment was considerably higher compared to ours, hence plateau (maximum) activity has been reached.…”

Hormonal Profile, Antioxidant Status and Some Biochemical Parameters during Pregnancy and Periparturient Period in Dromedary She Camel

“…That may be due to the activity of blood GSH that was increased with the increased lipid peroxidation, while GSH activity had a negative correlation with MDA production [69]. Therefore, an imbalance between increased production of ROS and reduced availability of antioxidant defense near parturition might increase oxidative stress and may contribute to periparturient disorders in dairy cows [70].…”

Prevalence of Clinical Mastitis and the Suitability of Gamma Function in Predicting Milk Yield of Mastitic and Non-Mastitic Friesian x Bunaji Dairy Cows in Zaria, Nigeria

“…The long days in milk by the high yielding cows could be the reason for the high prevalence of CM in the late lactation period in parity 2 and 3 cows, as, It is highly probable that the keratin layer in the udder could become less protective with prolonged milking therefore rendering the udder more susceptible toreinfection, possibly from a previous infection. The observed high prevalence of CM during early lactation periods in parity 1 could be attributed to new intra-mammary infections due to increase oxidative stress and reduced antioxidant defense mechanism post-partum as described by Sharma et al [18]. The prevalence of CM in early lactation period was highest among parity 3 cows than in parity1 and 2.…”